In:
American Journal of Physiology-Gastrointestinal and Liver Physiology, American Physiological Society, Vol. 264, No. 4 ( 1993-04-01), p. G589-G595
Abstract:
Cirrhosis is characterized by an increased deposition of extracellular matrix proteins, including type I collagen. Type I collagen is a product of two genes, alpha 1(I) and alpha 2(I), which are generally coordinately regulated. Since expression of type I collagen genes is increased during cirrhosis, understanding the structure and function of the regulatory components of the type I collagen genes should provide insight into the molecular pathogenesis of cirrhosis. This review will analyze the collagen alpha 1(I) gene with respect to chromatin structure, DNA methylation, regulation by agonists, and DNA-protein interactions.
Type of Medium:
Online Resource
ISSN:
0193-1857
,
1522-1547
DOI:
10.1152/ajpgi.1993.264.4.G589
Language:
English
Publisher:
American Physiological Society
Publication Date:
1993
detail.hit.zdb_id:
1477329-6
SSG:
12
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