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  • SAGE Publications  (2)
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  • 1
    Online Resource
    Online Resource
    Image correction for cone-beam computed tomography simulator using neural network corrector
    SAGE Publications ; 2017
    In:  Advances in Mechanical Engineering Vol. 9, No. 2 ( 2017-02), p. 168781401769047-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 9, No. 2 ( 2017-02), p. 168781401769047-
    Abstract: In this article, a neural network corrector is proposed to correct the image shift, yielding the degradation of three-dimensional image reconstruction, for each slice captured by cone-beam computed tomography simulator. There are 3 degrees of freedom in tube module of simulator; the central point of tube module should be aligned with the central point of detector module to guarantee the accurate image projection. However, the mechanism manufacturing and assembling tolerance will let the above aim cannot be met. Here, a standard kit is made to measure the image shift by 1° step from −10° to 10°. The measure data will be the input training data of proposed neural network corrector, and the corrected translation position will be the output of neural network corrector. The Levenberg–Marquardt learning algorithm adjusts the connected weights and biases of the neural network using a supervised gradient descent method, such that the defined error function can be minimized. To avoid the problem of overfitting and improve the generalized ability of the neural network, Bayesian regularization is added to the Levenberg–Marquardt learning algorithm. After the training of neural network corrector, the different target position commands are fed into the neural network corrector. Then, the corrected data from neural network corrector are fed to be the new position command to verify the image correction performance. Moreover, a phantom kit is made to check the corrected performance of the neural network corrector. Finally, the experimental results verify that the image shift can be reduced by the neural network corrector.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814017690476
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2501620-9
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  • 2
    Online Resource
    Online Resource
    Adipose-derived Stem Cells Stimulated with n -Butylidenephthalide Exhibit Therapeutic Effects in a Mouse Model of Parkinson’s Disease
    SAGE Publications ; 2018
    In:  Cell Transplantation Vol. 27, No. 3 ( 2018-03), p. 456-470
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 27, No. 3 ( 2018-03), p. 456-470
    Abstract: Parkinson’s disease (PD) causes motor dysfunction and dopaminergic cell death. Drug treatments can effectively reduce symptoms but often cause unwanted side effects. Stem cell therapies using cell replacement or indirect beneficial secretomes have recently emerged as potential therapeutic strategies. Although various types of stem cells have been proposed as possible candidates, adipose-derived stem cells (ADSCs) are easily obtainable, more abundant, less ethically disputed, and able to differentiate into multiple cell lineages. However, treatment of PD using adult stem cells is known to be less efficacious than neuron or embryonic stem cell transplantation. Therefore, improved therapies are urgently needed. n-Butylidenephthalide (BP), which is extracted from Angelica sinensis, has been shown to have anti-inflammatory and neuroprotective effects. Indeed, we previously demonstrated that BP treatment of ADSCs enhances the expression of neurogenesis and homing factors such as nuclear receptor related 1 protein, stromal-derived factor 1, and brain-derived neurotrophic factor. In the present study, we examined the ability of BP-pretreated ADSC transplantation to improve PD motor symptoms and protect dopamine neurons in a mouse model of PD. We evaluated the results using neuronal behavior tests such as beam walking, rotarod, and locomotor activity tests. ADSCs with or without BP pretreatment were transplanted into the striatum. Our findings demonstrated that ADSC transplantation improved motor abilities with varied efficacies and that BP stimulation improved the therapeutic effects of transplantation. Dopaminergic cell numbers returned to normal in ADSC-transplanted mice after 22 d. In summary, stimulating ADSCs with BP improved PD recovery efficiency. Thus, our results provide important new strategies to improve stem cell therapies for neurodegenerative diseases in future studies.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689718757408
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2020466-8
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