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  • Online Resource  (6)
  • Wiley  (6)
  • 2020-2024  (6)
  • 1
    Online Resource
    Online Resource
    ERCP in babies: Low risk of post‐ERCP pancreatitis – results from a multicentre survey
    Wiley ; 2020
    In:  United European Gastroenterology Journal Vol. 8, No. 1 ( 2020-02), p. 77-80
    Details
    In: United European Gastroenterology Journal, Wiley, Vol. 8, No. 1 ( 2020-02), p. 77-80
    Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) is rarely performed in newborns, and the risk of post‐ERCP pancreatitis (PEP) has not been defined in this age group. We therefore performed a European multicentre analysis of PEP rates and risk factors in children aged ≤1 year. Patients and methods Based on a sample size estimation, 135 consecutive ERCPs in 126 children aged ≤1 year were evaluated from five European centres, and the first ERCP per child analysed. All ERCPs and clinical reports were reviewed manually for PEP and associated risk factors. All ERCPs were performed by endoscopists with high ERCP expertise. Results No PEP was observed (0/126, 0.0%, CI 0–2.9%) despite the formal presence of multiple risk factors and despite lack of PEP prophylaxis (except one patient having received a pancreatic duct stent). The PEP rate was significantly lower than the PEP rate expected in adults with similar risk factors. Conclusions ERCP in children aged ≤1 year is safe in terms of PEP. The PEP risk is significantly lower in children aged ≤1 year than in adults, therefore no PEP prophylaxis seems to be needed in young children. Risk factors from adults may not apply to children under 1 year. Reluctance to perform diagnostic ERCP in suspected biliary anomalies should not be based on presumed PEP risk.
    Type of Medium: Online Resource
    ISSN: 2050-6406 , 2050-6414
    URL: Article
    DOI: 10.1177/2050640619874187
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2728585-6
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  • 2
    Online Resource
    Online Resource
    Characteristics of serum neurofilament light chain as a biomarker in hereditary spastic paraplegia type 4
    Wiley ; 2022
    In:  Annals of Clinical and Translational Neurology Vol. 9, No. 3 ( 2022-03), p. 326-338
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 9, No. 3 ( 2022-03), p. 326-338
    Abstract: While the anticipated rise of disease‐modifying therapies calls for reliable trial outcome parameters, fluid biomarkers are lacking in spastic paraplegia type 4 (SPG4), the most prevalent form of hereditary spastic paraplegia. We therefore investigated serum neurofilament light chain (sNfL) as a potential therapy response, diagnostic, monitoring, and prognostic biomarker in SPG4. Methods: We assessed sNfL levels in 93 patients with SPG4 and 60 healthy controls. The longitudinal study of sNfL levels in SPG4 patients covered a baseline, 1‐year follow‐up and 2‐year follow‐up visit. Results Levels of sNfL were significantly increased in patients with genetically confirmed SPG4 compared to healthy controls matched in age and sex ( p  = 0.013, r  = 0.2). Our cross‐sectional analysis revealed a greater difference in sNfL levels between patients and controls in younger ages with decreasing fold change of patient sNfL elevation at older ages. Over our observational period of 2 years, sNfL levels remained stable in SPG4 patients. Disease severity and progression did not correlate with sNfL levels. Interpretation: Our longitudinal data indicate a stable turnover of sNfL in manifest SPG4; therefore, sNfL levels are not suitable to monitor disease progression in SPG4. However, sNfL may be valuable as a therapy response biomarker, since its turnover could be modified by interventions. As the course of sNfL levels appears to be most dynamic around the onset of SPG4, the ability to detect a therapy response appears to be especially promising in younger patients, matching the need to initiate treatment in early disease stages.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Issue
    URL: Article
    DOI: 10.1002/acn3.v9.3
    DOI: 10.1002/acn3.51518
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2740696-9
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  • 3
    Online Resource
    Online Resource
    Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity
    Wiley ; 2022
    In:  Movement Disorders Vol. 37, No. 2 ( 2022-02), p. 405-410
    Details
    In: Movement Disorders, Wiley, Vol. 37, No. 2 ( 2022-02), p. 405-410
    Abstract: Lifestyle could influence the course of hereditary ataxias, but representative data are missing. Objective The objective of this study was to characterize lifestyle in spinocerebellar ataxia type 3 (SCA3) and investigate possible associations with disease parameters. Methods In a prospective cohort study, data on smoking, alcohol consumption, physical activity, physiotherapy, and body mass index (BMI) were collected from 243 patients with SCA3 and 119 controls and tested for associations with age of onset, disease severity, and progression. Results Compared with controls, patients with SCA3 were less active and consumed less alcohol. Less physical activity and alcohol abstinence were associated with more severe disease, but not with progression rates or age of onset. Smoking, BMI, or physiotherapy did not correlate with disease parameters. Conclusion Differences in lifestyle factors of patients with SCA3 and controls as well as associations of lifestyle factors with disease severity are likely driven by the influence of symptoms on behavior. No association between lifestyle and disease progression was detected. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v37.2
    DOI: 10.1002/mds.28844
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2041249-6
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  • 4
    Online Resource
    Online Resource
    Is there an association between social determinants and care dependency risk? A multi‐state model analysis of a longitudinal study
    Wiley ; 2020
    In:  Research in Nursing & Health Vol. 43, No. 3 ( 2020-06), p. 230-240
    Details
    In: Research in Nursing & Health, Wiley, Vol. 43, No. 3 ( 2020-06), p. 230-240
    Abstract: Despite a growing body of knowledge about the morbidities and functional impairment that frequently lead to care dependency, the role of social determinants is not yet well understood. The purpose of this study was to examine the effect of social determinants on care dependency onset and progression. We used data from the Berlin Initiative Study, a prospective, population‐based cohort study including 2,069 older participants living in Berlin. Care dependency was defined as requiring substantial assistance in at least two activities of daily living for 90 min daily (level 1) or 3+ hours daily (level 2). Multi‐state time to event regression modeling was used to estimate the effects of social determinants (partnership status, education, income, and sex), morbidities, and health behaviors, characteristics, and conditions. During the study period, 556 participants (27.5%) changed their status of care dependency. Participants without a partner at baseline were at a higher risk to become care‐dependent than participants with a partner (hazard ratio [HR], 95% confidence interval [CI] : 1.24 (1.02–1.51)). After adjustment for other social determinants, morbidities and health behaviors, characteristics, and conditions the risk decreased to a HR of 1.19 (95% CI: 0.79–1.79). Results indicate that older people without a partner may tend to be at higher risk of care dependency onset but not at higher risk of care dependency progression. Clinicians should inquire about and consider patients’ partnership status as they evaluate care needs.
    Type of Medium: Online Resource
    ISSN: 0160-6891 , 1098-240X
    URL: Issue
    URL: Article
    DOI: 10.1002/nur.v43.3
    DOI: 10.1002/nur.22022
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2002160-4
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  • 5
    Online Resource
    Online Resource
    Neurofilament light chain is a cerebrospinal fluid biomarker in hereditary spastic paraplegia
    Wiley ; 2021
    In:  Annals of Clinical and Translational Neurology Vol. 8, No. 5 ( 2021-05), p. 1122-1131
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 8, No. 5 ( 2021-05), p. 1122-1131
    Abstract: Despite the need for diagnostics and research, data on fluid biomarkers in hereditary spastic paraplegia (HSP) are scarce. We, therefore, explore Neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of patients with hereditary spastic paraplegia and provide information on the influence of demographic factors. Methods The study recruited 59 HSP cases (33 genetically confirmed) and 59 controls matched in age and sex. Neurofilament light chain levels were assessed by enzyme‐linked immunosorbent assay. The statistical analysis included the effects of age, sex, and genetic status (confirmed vs. not confirmed). Results Levels of CSF NfL were significantly increased in patients with hereditary spastic paraplegia compared to controls (median 741 pg/mL vs. 387 pg/mL, p  〈  0.001). Age (1.4% annual increase) and male sex (81% increase) impacted CSF NfL levels in patients. The age‐dependent increase of CSF NfL levels was steeper in controls (2.6% annual increase). Thus, the CSF NfL ratio of patients and matched controls—expressing patients’ fold increases in CSF NfL—declined considerably with age. Interpretation CSF NfL is a reliable cross‐sectional biomarker in hereditary spastic paraplegia. Sex is a relevant factor to consider, as male patients have remarkably higher CSF NfL levels. While levels also increase with age, the gap between patients and controls is narrowing in older subjects. This indicates distinct temporal dynamics of CSF NfL in patients with hereditary spastic paraplegia, with a rise around phenotypic conversion and comparatively static levels afterward.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Issue
    URL: Article
    DOI: 10.1002/acn3.v8.5
    DOI: 10.1002/acn3.51358
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2740696-9
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  • 6
    Online Resource
    Online Resource
    Risk assessment in COVID‐19: Prognostic importance of cardiovascular parameters
    Wiley ; 2022
    In:  Clinical Cardiology Vol. 45, No. 9 ( 2022-09), p. 943-951
    Details
    In: Clinical Cardiology, Wiley, Vol. 45, No. 9 ( 2022-09), p. 943-951
    Abstract: Cardiovascular risk factors and comorbidities are highly prevalent among COVID‐19 patients and are associated with worse outcomes. Hypothesis We therefore investigated if established cardiovascular risk assessment models could efficiently predict adverse outcomes in COVID‐19. Furthermore, we aimed to generate novel risk scores including various cardiovascular parameters for prediction of short‐ and midterm outcomes in COVID‐19. Methods We included 441 consecutive patients diagnosed with SARS‐CoV‐2 infection. Patients were followed‐up for 30 days after the hospital admission for all‐cause mortality (ACM), venous/arterial thromboembolism, and mechanical ventilation. We further followed up the patients for post‐COVID‐19 syndrome for 6 months and occurrence of myocarditis, heart failure, acute coronary syndrome (ACS), and rhythm events in a 12‐month follow‐up. Discrimination performance of DAPT, GRACE 2.0, PARIS‐CTE, PREDICT‐STABLE, CHA2‐DS2‐VASc, HAS‐BLED, PARIS‐MB, PRECISE‐DAPT scores for selected endpoints was evaluated by ROC‐analysis. Results Out of established risk assessment models, GRACE 2.0 score performed best in predicting combined endpoint and ACM. Risk assessment models including age, cardiovascular risk factors, echocardiographic parameters, and biomarkers, were generated and could successfully predict the combined endpoint, ACM, venous/arterial thromboembolism, need for mechanical ventilation, myocarditis, ACS, heart failure, and rhythm events. Prediction of post‐COVID‐19 syndrome was poor. Conclusion Risk assessment models including age, laboratory parameters, cardiovascular risk factors, and echocardiographic parameters showed good discrimination performance for adverse short‐ and midterm outcomes in COVID‐19 and outweighed discrimination performance of established cardiovascular risk assessment models.
    Type of Medium: Online Resource
    ISSN: 0160-9289 , 1932-8737
    URL: Issue
    URL: Article
    DOI: 10.1002/clc.v45.9
    DOI: 10.1002/clc.23883
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2048223-1
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