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  • Online Resource  (35)
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  • 2020-2024  (35)
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  • Wiley  (35)
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  • 1
    Online Resource
    Online Resource
    NAV2 positively modulates inflammatory response of fibroblast‐like synoviocytes through activating Wnt/β‐catenin signaling pathway in rheumatoid arthritis
    Wiley ; 2021
    In:  Clinical and Translational Medicine Vol. 11, No. 4 ( 2021-04)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 11, No. 4 ( 2021-04)
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v11.4
    DOI: 10.1002/ctm2.376
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2697013-2
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  • 2
    Online Resource
    Online Resource
    Synergistic effects of vegetation restoration and check dams on water erosion in a slope‐gully system
    Wiley ; 2023
    In:  Land Degradation & Development Vol. 34, No. 12 ( 2023-07-30), p. 3581-3592
    Details
    In: Land Degradation & Development, Wiley, Vol. 34, No. 12 ( 2023-07-30), p. 3581-3592
    Abstract: Restoring vegetation and constructing check dams are important measures for controlling water erosion in slope‐gully systems. However, percolation through the dam body could lead to shortened runoff paths in the gully. Moreover, the synergistic effects of vegetation patterns and siltation‐induced runoff path length decrease (RPLD) in slope‐gully systems on reducing water erosion remain unclear. In this study, 20 physical models of slope‐gully systems were constructed to quantitatively evaluate the synergistic effect of these measures under simulated rainfall. The models included four slope vegetation patterns (no vegetation, up‐slope, middle‐slope, and down‐slope) and five levels of RPLD in the gully (0, 1, 2, 3, and 4 m). Owing to synergistic effects, combined measures led to a more considerable reduction in soil and water loss than a single measure. Furthermore, the synergistic effect was related to vegetation patterns and shorter siltation‐induced runoff paths. The mean synergistic effect produced the following runoff yield order: down‐slope (2.84%)  〉  middle‐slope (2.81%)  〉  up‐slope (1.78%); and 4 m (3.18%)  〉  3 m (2.66%)  〉  2 m (2.29%)  〉  1 m (1.78%). The sediment yields were in the following order: down‐slope (18.15%)  〉  middle‐slope (12.63%)  〉  up‐slope (6.67%), and 4 m (14.56%)  〉  3 m (12.82%)  〉  2 m (11.73%)  〉  1 m (10.82%). These results suggest that revegetation of the lower parts of the slope, along with check dams, will be more effective for controlling soil erosion. Such synergistic effects should be considered in future soil erosion modeling.
    Type of Medium: Online Resource
    ISSN: 1085-3278 , 1099-145X
    URL: Issue
    URL: Article
    DOI: 10.1002/ldr.v34.12
    DOI: 10.1002/ldr.4704
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2021787-0
    detail.hit.zdb_id: 1319202-4
    SSG: 14
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  • 3
    Online Resource
    Online Resource
    Myricetin reverses epithelial–endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1
    Wiley ; 2022
    In:  Phytotherapy Research Vol. 36, No. 4 ( 2022-04), p. 1807-1821
    Details
    In: Phytotherapy Research, Wiley, Vol. 36, No. 4 ( 2022-04), p. 1807-1821
    Abstract: Most antiangiogenic inhibitors targeting endothelium‐dependent vessels cannot inhibit tumor growth but promote tumor invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct endothelium‐dependent vessels. Inhibiting VM may be a novel antiangiogenic strategy against alternative tumor vascularization. In this paper, myricetin was selected from among several flavonoid compounds as an effective PAR1 antagonist. In two different hepatocellular carcinoma (HCC) cell lines high‐expressed PAR1, myricetin inhibited cell migration, invasion and VM formation and reversed the expression of epithelial–endothelial transition (EET) markers by inhibiting PAR1 activation. Knockout of PAR1 inhibited HCC cell invasion and metastasis and weakened the inhibitory effect of myricetin on HCC cells. The migration, invasion and tube formation ability of PLC‐PRF‐5 cells were enhanced after PAR1 overexpression, and the inhibitory effect of myricetin was enhanced. A docking assay revealed that myricetin binds to Leu258 and Thr261 in the PAR1 activity pocket. Mutation of Leu258 and Thr261 inhibited the antitumor effect of myricetin in vitro and in vivo. In summary, myricetin reverses PAR1‐mediated EET and inhibits HCC cell invasion, metastasis, VM formation and angiogenesis by targeting PAR1, and Leu258 and Thr261 of PAR1 participate in VM and angiogenesis in HCC tissues.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v36.4
    DOI: 10.1002/ptr.7427
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Influencing factors of resource utilisation in haemodialysis patients—Based on socioecological pyramid model
    Wiley ; 2022
    In:  Journal of Clinical Nursing Vol. 31, No. 5-6 ( 2022-03), p. 770-780
    Details
    In: Journal of Clinical Nursing, Wiley, Vol. 31, No. 5-6 ( 2022-03), p. 770-780
    Abstract: To describe the current situation and analyse influencing factors of resource utilisation in maintenance haemodialysis patients. Background The self‐management level of patients undergoing maintenance haemodialysis in China is low. The applicability of the Chronic Illness Resources Survey in Chinese maintenance haemodialysis patients has been validated, and this survey can be used to assess the utilisation of self‐management support resources among haemodialysis patients. Determining the influencing factors of resource utilisation can help improve the self‐management behaviour of haemodialysis patients and control the progression of the disease. Design A descriptive study design was chosen. Methods A convenience sample of 314 patients undergoing haemodialysis was recruited from dialysis centres in three hospitals in western Xinjiang from June 2018–April 2019. SPSS19.0 software was used to describe the current situation of resource utilisation. Moreover, t test, analysis of variance and multivariate linear regression were applied to explore the influencing factors of patients’ resource utilisation. Standards for observational studies STROBE Statement checklist‐v4 were chosen on reporting the study process. Results The average score of the total resource utilisation was 2.95 ± 0.51. The average item score of seven dimensions from high to low was 3.46 for medical staff, 3.32 for personal, 3.22 for family and friends, 3.16 for work‐related, 3.12 for media policy, 2.55 for neighbourhood/community and 2.23 for organisation. Multiple linear regression showed that there have six main factors, which explained 65.4% of the variance of haemodialysis patients’ resource utilisation. Conclusions The personal, family and friends, work and media and policy subscales were rated the highest, with support from neighbourhood/community and organisation rated the lowest. In general, participants perceived moderate levels of support. Government and healthcare team should pay more attention on haemodialysis patients who had low level of education, poor economic conditions and poor mental condition. Relevance to clinical practice ESRD has caused a burden on healthcare expenditure and has become a critical public health problem worldwide. Self‐management is particularly important for dialysis patients which have attracted extensive interest. In the future research, we can use this questionnaire to evaluate the related resources of disease management of dialysis patients, encourage patients to make full use of the resources around them and focus on those patients with low education and monthly income level and bad mental state.
    Type of Medium: Online Resource
    ISSN: 0962-1067 , 1365-2702
    URL: Issue
    URL: Article
    DOI: 10.1111/jocn.v31.5-6
    DOI: 10.1111/jocn.15935
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2006661-2
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  • 5
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    Online Resource
    Byakangelicin protects against carbon tetrachloride–induced liver injury and fibrosis in mice
    Wiley ; 2020
    In:  Journal of Cellular and Molecular Medicine Vol. 24, No. 15 ( 2020-08), p. 8623-8635
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 24, No. 15 ( 2020-08), p. 8623-8635
    Abstract: Liver fibrosis is a disease caused by long‐term damage that is related to a number of factors. The current research on the treatment of liver fibrosis mainly focuses on the activation of hepatic stellate cell, in addition to protecting liver cells. byakangelicin has certain anti‐inflammatory ability, but its effect on liver fibrosis is unclear. This study aims to explore whether byakangelicin plays a role in the development of liver fibrosis and to explore its mechanism. We determined that byakangelicin has a certain ability to resist fibrosis and reduce liver cell damage in a model of carbon tetrachloride–induced liver fibrosis in mice. Thereafter, we performed further verification in vitro. The signalling pathways of two important pro‐fibrotic cytokines, transforming growth factor‐β and platelet‐derived growth factor, were studied. Results showed that byakangelicin can inhibit related pathways. According to the hepatoprotective effect of byakangelicin observed in animal experiments, we studied the effect of byakangelicin on 4‐HNE–induced hepatocyte (HepG2) apoptosis and explored its related pathways. The results showed that byakangelicin could attenuate 4‐HNE–induced hepatocyte apoptosis via inhibiting ASK‐1/JNK signalling. In conclusion, byakangelicin could improve carbon tetrachloride–induced liver fibrosis and liver injury by inhibiting hepatic stellate cell proliferation and activation and suppressing hepatocyte apoptosis.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v24.15
    DOI: 10.1111/jcmm.15493
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2076114-4
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  • 6
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    Online Resource
    Harnessing the Hybridization of a Metal‐Organic Framework and Superbase‐Derived Ionic Liquid for High‐Performance Direct Air Capture of CO 2
    Wiley ; 2023
    In:  Small
    Details
    In: Small, Wiley
    Abstract: Direct air capture (DAC) of CO 2 has emerged as the most promising “negative carbon emission” technologies. Despite being state‐of‐the‐art, sorbents deploying alkali hydroxides/amine solutions or amine‐modified materials still suffer from unsolved high energy consumption and stability issues. In this work, composite sorbents are crafted by hybridizing a robust metal‐organic framework (Ni‐MOF) with superbase‐derived ionic liquid (SIL), possessing well maintained crystallinity and chemical structures. The low‐pressure (0.4 mbar) volumetric CO 2 capture assessment and a fixed‐bed breakthrough examination with 400 ppm CO 2 gas flow reveal high‐performance DAC of CO 2 (CO 2 uptake capacity of up to 0.58 mmol g −1 at 298 K) and exceptional cycling stability. Operando spectroscopy analysis reveals the rapid (400 ppm) CO 2 capture kinetics and energy‐efficient/fast CO 2 releasing behaviors. The theoretical calculation and small‐angle X‐ray scattering demonstrate that the confinement effect of the MOF cavity enhances the interaction strength of reactive sites in SIL with CO 2 , indicating great efficacy of the hybridization. The achievements in this study showcase the exceptional capabilities of SIL‐derived sorbents in carbon capture from ambient air in terms of rapid carbon capture kinetics, facile CO 2 releasing, and good cycling performance.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Article
    DOI: 10.1002/smll.202302708
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2168935-0
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  • 7
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    Online Resource
    Application of Simultaneous 18 F‐FDG PET With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted MR Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma
    Wiley ; 2022
    In:  Journal of Magnetic Resonance Imaging Vol. 56, No. 1 ( 2022-07), p. 63-74
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 56, No. 1 ( 2022-07), p. 63-74
    Abstract: Ki‐67 proliferation index (PI) is important for providing information on tumor behavior, treatment response, and prognosis. Integrated positron emission tomography/magnetic resonance (PET/MR) may have the potential to assess Ki‐67 PI in patients with lung adenocarcinoma. Purpose To explore the value of simultaneous 18 F‐fluorodeoxyglucose ( 18 F‐FDG) PET/MR‐derived parameters in assessing the proliferation status of lung adenocarcinoma and to determine the best combination of parameters. Study Type Prospective. Population Seventy‐eight patients with lung adenocarcinoma and with Ki‐67 PI. Field Strength/Sequence 3. 0 T , simultaneous PET / MRI including diffusion‐weighted imaging ( DWI ) and 18 F‐FDG PET . Assessment DWI‐derived parameters, namely, apparent diffusion coefficient (ADC), true diffusion coefficient ( D ), pseudo diffusion coefficient ( D *), perfusion fraction ( f ), diffusion heterogeneity index ( α ), and distributed diffusion coefficient (DDC); and PET‐derived parameters, namely, maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), and total lesion glycolytic volume (TLG), were calculated and compared between the high ( 〉 25%) and low (≤25%) Ki‐67 PI groups. The correlations between PET‐derived parameters and DWI‐derived parameters were analyzed. Statistical Tests Student's t ‐test, Mann–Whitney U test, chi‐square test, and receiver operating characteristic (ROC) curves. A P ‐value 〈 0.05 was considered statistically significant. Results The SUV max , MTV, TLG, ADC, D , and DDC values were significantly different between the high ( N  = 35) and low Ki‐67 PI groups ( N  = 43). D , SUV max , and MTV independently predicted the Ki‐67 PI status. The combination of D , SUV max , and MTV had the largest area under the ROC curve (AUC = 0.900), which was significantly larger than the AUC alone of DDC (AUC = 0.725), SUV max (AUC = 0.815), MTV (AUC = 0.774), or TLG (AUC = 0.783). The perfusion fraction did not correlate with SUV max , MTV, or TLG ( r  = −0.03, −0.11, and −0.04, respectively; P  = 0.786, 0.348, and 0.733). Data Conclusion The combination of D , SUV max , and MTV may predict Ki‐67 PI status. No correlation was observed between perfusion parameters and metabolic parameters. Level of Evidence 1 Technical Efficacy Stage 2
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v56.1
    DOI: 10.1002/jmri.28010
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1497154-9
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  • 8
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    Online Resource
    Unraveling the Gonyaulax baltica Species Complex: Cyst–theca Relationship of Impagidinium variaseptum , Spiniferites pseudodelicatus sp. nov. and S. ristingensis (Gonyaulacaceae, Dinophyceae), With Descriptions of Gonyaulax bohaiensis sp. nov, G. amoyensis sp. nov. and G. portimonensis sp. nov.
    Wiley ; 2022
    In:  Journal of Phycology Vol. 58, No. 3 ( 2022-06), p. 465-486
    Details
    In: Journal of Phycology, Wiley, Vol. 58, No. 3 ( 2022-06), p. 465-486
    Abstract: The taxonomy of the extant dinoflagellate genus Gonyaulax is challenging since its thecate morphology is rather conservative. In contrast, cysts of Gonyaulax are varied in morphology and have been related with the fossil‐based genera Spiniferites and Impagidinium . To better understand the systematics of Gonyaulax species, we performed germination experiments on cysts that can be identified as S. ristingensis , an unidentified Spiniferites with petaloid processes here described as Spiniferites pseudodelicatus sp. nov. and Impagidinium variaseptum from Chinese and Portuguese waters. Despite marked differences in cyst morphology, motile cells of S . pseudodelicatus and I. variaseptum are indistinguishable from Gonyaulax baltica . Motile cells hatched from S. ristingensis are morphologically similar to G. baltica as well but differ in the presence of one pronounced antapical spine. Three new species, Gonyaulax amoyensis (cyst equivalent S. pseudodelicatus ), Gonyaulax bohaiensis (cyst equivalent I. variaseptum ), and Gonyaulax portimonensis (cyst equivalent S. ristingensis ), were erected. In addition, a new ribotype (B) of G. baltica was reported from South Korea and a bloom of G. baltica ribotype B is reported from New Zealand. Molecular phylogeny based on LSU and SSU rRNA gene sequences revealed that Gonyaulax species with minute or short antapical spines formed a well‐resolved clade, whereas species with two pronounced antapical spines or lack of antapical spines formed the sister clade. Six strains of four above species were examined for yessotoxin production by liquid chromatography coupled with tandem mass spectrometry, and very low concentrations of yessotoxin were detected for one G. bohaiensis strain.
    Type of Medium: Online Resource
    ISSN: 0022-3646 , 1529-8817
    URL: Issue
    URL: Article
    DOI: 10.1111/jpy.v58.3
    DOI: 10.1111/jpy.13245
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 281226-5
    detail.hit.zdb_id: 1478748-9
    SSG: 12
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  • 9
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    Online Resource
    Single‐cell analyses reveal suppressive tumor microenvironment of human colorectal cancer
    Wiley ; 2021
    In:  Clinical and Translational Medicine Vol. 11, No. 6 ( 2021-06)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 11, No. 6 ( 2021-06)
    Abstract: Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes tumor progress and determines the outcome of therapeutic response. Here, we comprehensively characterized transcriptomes of 34,037 single cells obtained from 12 treatment‐naïve patients with colorectal cancer. Our comprehensive evaluation revealed attenuated B‐cell antigen presentation, distinct regulatory T‐cell clusters with different origin and novel polyfunctional tumor associated macrophages associated with CRC. Moreover, we identified expanded XCL1 + T‐cell clusters associated with tumor mutational burden high status. We further explored the underlying molecular mechanisms by profiling epigenetic landscape and inferring transcription factor motifs using single‐cell ATAC‐seq. Our dataset and analysis approaches herein provide a rich resource for further study of the impact of immune cells and translational research for human colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v11.6
    DOI: 10.1002/ctm2.422
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2697013-2
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  • 10
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    Online Resource
    Histone methyltransferase Smyd3 is a new regulator for vascular senescence
    Wiley ; 2020
    In:  Aging Cell Vol. 19, No. 9 ( 2020-09)
    Details
    In: Aging Cell, Wiley, Vol. 19, No. 9 ( 2020-09)
    Abstract: Endothelial cell senescence is one of the main risk factors contributing to vascular diseases. As increasing number of “epigenetic drugs” entering clinical trials, understanding the mechanism of epigenetic regulation in vascular aging has significant implications in finding targets to cure vascular diseases. However, the epigenetic regulation of endothelial senescence remains unclear. Based on the findings that increased protein level of histone H3 lysine 4 (H3K4) methyltransferase Smyd3 and elevated H3K4me3 modification happened in angiotensin II (Ang II)‐induced senescence in rat endothelial cells, we are curious about whether and how Smyd3 can regulate endothelial senescence. We found that an increase of Smyd3 alone promoted senescence‐associated phenotypes, while knockdown of Smyd3 blocked senescence in endothelial cells. Furthermore, Smyd3‐specific inhibitor reversed vascular senescence‐associated phenotypes at cellular level. Importantly, Ang II‐induced vascular senescence can be greatly alleviated in Smyd3 knockout (KO) mice and those treated with Smyd3 inhibitor. Mechanistically, Smyd3 directly bound to the promoter region of Cdkn1a (coding for p21), then caused its increased H3K4me3 level and elevated gene expression, and ultimately gave rise to senescence‐associated phenotypes. Intriguingly, Smyd3‐mediated p21 upregulated expression also exists in human tissues of vascular disease, indicating it is probably an evolutionarily conserved mechanism in regulating vascular senescence. Thus, Smyd3 can act as a novel factor regulating endothelial senescence through transcriptionally promoting p21 expression. Blocking the Smyd3‐p21 signaling axis may also have potential medical implications in treating diseases related to vascular aging.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    DOI: 10.1111/acel.v19.9
    DOI: 10.1111/acel.13212
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2099130-7
    SSG: 12
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