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  • Online Resource  (33)
  • Hindawi Limited  (33)
  • 2020-2024  (33)
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  • Online Resource  (33)
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  • Hindawi Limited  (33)
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  • 2020-2024  (33)
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  • 1
    Online Resource
    Online Resource
    Knockdown of lncRNA HOXD-AS2 Improves the Prognosis of Glioma Patients by Inhibiting the Proliferation and Migration of Glioma Cells
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-11-9), p. 1-11
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-11-9), p. 1-11
    Abstract: Objective. Increasing studies reported that long noncoding RNAs are involved in regulating glioma progression. However, the specific roles and mechanisms of lncRNAs in glioma remain unclear. Here, we sought to explore the functions of HOXD-AS2 in glioma progression. Methods. Gene expressions of lncRNAs in 5 normal brain tissue specimens and 5 glioblastoma tissue specimens were detected by gene expression profile chip technology. Bioinformatic analysis was performed to see whether differential expression of lncRNAs played any significant role in glioma occurrence and progression. The relationship between HOXD-AS2 level and clinical prognosis of the patients was analyzed. HOXD-AS2 was specifically interfered with by siRNA technology to observe its effects on U251 cell growth, proliferation, apoptosis, and invasion. Results. The expression level of HOXD-AS2 gene in glioma was significantly higher than that in the normal brain tissue, which was related to the tumor grade. The level of HOXD-AS2 gene in patients with high-grade glioma was higher than that in patients with low-grade glioma. High expression of HOXD-AS2 gene was a risk factor for poor prognosis of glioma patients. Knocking down the expression of HOXD-AS2 in glioma cell line U251 arrested the cell cycle and reduced the cell proliferation. Furthermore, it could significantly reduce the migration ability of the cells but had no significant effect on the invasion. Conclusion. HOXD-AS2 is an oncogenic lncRNA associated with the poor prognosis of glioma. Knockdown of HOXD-AS2 may reduce the growth of glioma, which may provide a new avenue for treatment.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/9337647
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    Effects of a Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle
    Hindawi Limited ; 2023
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2023 ( 2023-1-6), p. 1-20
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2023 ( 2023-1-6), p. 1-20
    Abstract: Aim. Hyperuricemia (HUA) has received increased attention in the last few decades due to its global prevalence. Our previous study found that administration of a macroporous resin extract of Dendrobium officinale leaves (DoMRE) to rats with HUA that was induced by exposure to potassium oxazine combined with fructose and a high-purine diet led to a significant reduction in serum uric acid (SUA) levels. The aim of this study was to explore the effects of DoMRE on hyperuricemia induced by anthropomorphic unhealthy lifestyle and to elucidate its possible mechanisms of action. Methods. Dosages (5.0 and 10.0 g/kg/day) of DoMRE were administered to rats daily after induction of HUA by anthropomorphic unhealthy lifestyle for 12 weeks. The levels of UA in the serum, urine, and feces; the levels of creatinine (Cr) in the serum and urine; and the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum were all measured using an automatic biochemical analyzer. The activities of xanthine oxidase (XOD) and adenosine deaminase (ADA) in the serum, liver, and intestine tissue supernatant were measured using appropriate kits for each biological target. The expressions levels of UA transporters (ABCG2 and GLUT9), tight junction (TJ) proteins (ZO-1 and occludin), and inflammatory factors (IL-6, IL-8, and TNF-α) in the intestine were assayed by immunohistochemical (IHC) staining. Hematoxylin and eosin (H & E) staining was used to assess histological changes in the renal and intestinal tissues. Results. DoMRE treatment significantly reduced SUA levels and concomitantly increased fecal UA (FUA) levels and the fractional excretion of UA (FEUA) in HUA rats. Furthermore, DoMRE significantly reduced both the XOD activity in the serum, liver, and intestine and the ADA activity in the liver and intestine. DoMRE also effectively regulated the expression of GLUT9 and ABCG2 in the intestine, and it significantly upregulated the expression of the intestinal TJ proteins ZO-1 and occludin. Therefore, DoMRE reduced the damage to the intestinal barrier function caused by the increased production of inflammatory factors due to HUA to ensure normal intestinal UA excretion. Conclusion. DoMRE demonstrated anti-HUA effects in the HUA rat model induced by an anthropomorphic unhealthy lifestyle, and the molecular mechanism appeared to involve the regulation of urate transport-related transporters (ABCG2 and GLUT9) in the intestine, protection of the intestinal barrier function to promote UA excretion, and inhibition of XOD and ADA activity in the liver and intestine to inhibit UA production in the HUA-induced rats.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2023/9990843
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2148302-4
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  • 3
    Online Resource
    Online Resource
    Effects of salinity on reproductive characteristics and embryo quality of Eriocheir sinensis
    Hindawi Limited ; 2022
    In:  Aquaculture Research Vol. 53, No. 14 ( 2022-10), p. 4970-4979
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 53, No. 14 ( 2022-10), p. 4970-4979
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.v53.14
    DOI: 10.1111/are.15983
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 4
    Online Resource
    Online Resource
    Inversion Method of Initial In Situ Stress Field Based on BP Neural Network and Applying Loads to Unit Body
    Hindawi Limited ; 2020
    In:  Advances in Civil Engineering Vol. 2020 ( 2020-11-20), p. 1-15
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2020 ( 2020-11-20), p. 1-15
    Abstract: The initial in situ stress field is the fundamental factor causing the deformation and failure of underground engineering and is an important basis for the feasibility analysis, design, and construction of underground engineering. However, it is difficult to obtain the whole in situ stress field of large-scale underground engineering in difficult and dangerous areas by field measurement. In view of the fact that the measured in situ stress components (σxx, σyy, σzz, τxy, τxz, τyz) of Sichuan-Tibet Railway in China are linear with the buried depth, a method is proposed to solve the in situ stress by applying corresponding loads to all unit bodies in the calculation area based on BP neural network and FLAC3D. Through this method, the in situ stress of the tunnel is inverted. The results show that both the maximum principal stress and minimum principal stress increase with the increase of buried depth, and when the tunnel passes through faults or anticlines, the main stress will suddenly drop. Furthermore, compared with the results of the multiple linear regression method, it is found that the proposed method has higher accuracy; especially for the simulation of the maximum horizontal principal stress and vertical stress, the average relative error is reduced by 26.44% and 77.27%, respectively. The research in this paper can provide a new idea for the initial in situ stress inversion of engineering.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2020/8840940
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2449760-5
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  • 5
    Online Resource
    Online Resource
    Differential Evolution Optimized a Second-Order Divided Difference Particle Filter
    Hindawi Limited ; 2020
    In:  Journal of Electrical and Computer Engineering Vol. 2020 ( 2020-02-24), p. 1-9
    Details
    In: Journal of Electrical and Computer Engineering, Hindawi Limited, Vol. 2020 ( 2020-02-24), p. 1-9
    Abstract: In order to improve the estimation accuracy of particle filter algorithm in a nonlinear system state estimation problem, a new algorithm based on the second-order divided difference filter to generate the proposed distribution and the differential evolution algorithm for resampling is proposed. The second-order divided difference based on Strling’s interpolation formula is used to generate approximations to nonlinear dynamics, which avoids the evaluation of the Jacobian derivative matrix and is easy to implement. Cholesky factorization is used to ensure the positive definiteness of the covariance matrix. The truncated errors of the local linearization are reduced to a certain extent, and the approximation degree of the proposed distribution to the posterior probability of the system state is improved. The differential evolution algorithm is used to replace the traditional resampling algorithm, which effectively mitigates the problem of particle degradation. Monte Carlo simulation experiments show the effectiveness of the new algorithm.
    Type of Medium: Online Resource
    ISSN: 2090-0147 , 2090-0155
    URL: Article
    DOI: 10.1155/2020/9541624
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2582829-0
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  • 6
    Online Resource
    Online Resource
    OX40-Fc Fusion Protein Alleviates PD-1-Fc-Aggravated Rheumatoid Arthritis by Inhibiting Inflammatory Response
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-2-17), p. 1-11
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-2-17), p. 1-11
    Abstract: Background. Researches have confirmed that the abnormal signals of OX40 and PD-1 lead to the changes of T cell biological behavior, thus participating the immunopathological process of RA. However, the pathogenesis of RA immunopathological process has not been clarified yet. Methods. 30 DBA/1 mice were randomly divided into 5 groups (6 mice per group): control group, collagen-induced arthritis (CIA) group, PD-1-Fc/CIA group, OX40-Fc/CIA group, and PD-1-Fc + OX40-Fc/CIA group. The pathological changes in mice joints were observed by H & E staining. The proportion of CD4+ T, CD8+ T, CD28+, and CD19+ cells in peripheral blood mononuclear cells (PBMCs) was detected by flow cytometry. Serum inflammatory factors (CRP, IL-2, IL-4, IL-1β, INF-γ) and bone metabolism-related genes (CTX-I, TRACP-5b, BALP) were detected by ELISA assay. Western blotting was applied to measure the NF-κB signaling pathway-related protein (p-IKKβ, p-IκBα, p50) expression in synovial tissue of mice joint. Results. Compared with the control group, CIA mice showed significant increases in arthritis score and pathological score. In the CIA group, a marked decrease was identified in the proportion of CD8+ T, CD19+, and CD68+ cells. Additionally, the CIA group was associated with upregulation of secretion of inflammatory factors in serum and expression of bone metabolism-related genes and NF-κB pathway-related proteins. Compared with the CIA group, the same indexes above showed a further aggravation in the PD-1-Fc group while all indexes improved in the OX40-Fc group. Besides, OX40-Fc fusion protein slowed down significantly the further deterioration of CIA mouse pathological process caused by PD-1-Fc fusion protein. Conclusion. OX40-Fc fusion protein alleviates PD-1-Fc-aggravated RA by inhibiting inflammatory response. This research provides biological markers with clinical significance for diagnosis and prognosis of RA, as well as offers theoretical and experimental foundation to the new targets for immune intervention.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/6244175
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 7
    Online Resource
    Online Resource
    Auricular Intradermal Acupuncture as a Supplementary Motor Rehabilitation Strategy in Poststroke Patients: A Randomized Preliminary Clinical Study
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-03-19), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-03-19), p. 1-8
    Abstract: We have explored the potential of auricular intradermal acupuncture (AIA) in standard rehabilitation and acupuncture treatment for motor recovery in poststroke patients. This was a randomized, controlled preliminary clinical study in which the patients were randomly assigned to the CT group (conventional treatment, standard rehabilitation, and routine acupuncture) or AIA group (AIA combined with conventional treatment) and underwent 6 sessions in 1 week (6 days). Standard procedures and previously reported acupuncture points were used. Clinical outcomes were measured by the Fugl-Meyer motor assessment (FMA) of flexor and extensor synergy movement (FSM and ESM) of the upper and lower extremities (UE and LE) at days 0, 3, and 6. The assessment was performed by blinded assessors. The AIA group showed a significant increase in FMA-UE/FMA-LE scores on day 3 ( P = 0.012 and 0.001, respectively) and day 6 ( P = 0.041 and P 〈 0.001 , respectively), but this was not observed in the CT group. Furthermore, unlike the CT group, the AIA group exhibited a significant increase in the FMA-LE score on day 3 ( P = 0.004 ) and the FMA-UE scores on day 6 ( P = 0.048 ). Finally, the correlation between ESM and FMA-UE/FMA-LE was higher than that between FSM and FMA-UE/FMA-LE after treatment: for ESM and UE, r  = 0.759, P = 0.007 ; for ESM and LE, r  = 0.697, P = 0.003 ; for FSM and UE, r  = 0.604, P = 0.049 ; for FSM and LE, r  = 0.347, P = 0.188 . AIA is useful for motor rehabilitation in poststroke patients, particularly in terms of improving extensor synergy. This trial is registered with CHiCTR1800020150 .
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/5094914
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 8
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    Online Resource
    Chinese Herbal Medicine Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-12-7), p. 1-17
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-12-7), p. 1-17
    Abstract: Myocardial ischemia/reperfusion injury is the main cause of increased mortality and disability in cardiovascular diseases. The injury involves many pathological processes, such as oxidative stress, calcium homeostasis imbalance, inflammation, and energy metabolism disorders, and these pathological stimuli can activate endoplasmic reticulum stress. In the early stage of ischemia, endoplasmic reticulum stress alleviates the injury as an adaptive survival response, but the long-term stress on endoplasmic reticulum amplifies oxidative stress, inflammation, and calcium overload to accelerate cell damage and apoptosis. Therefore, regulation of endoplasmic reticulum stress may be a mechanism to improve ischemia/reperfusion injury. Chinese herbal medicine has a long history of clinical application and unique advantages in the treatment of ischemic heart diseases. This review focuses on the effect of Chinese herbal medicine on myocardial ischemia/reperfusion injury from the perspective of regulation of endoplasmic reticulum stress.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2021/4963346
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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  • 9
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    Online Resource
    Application of Improved Simplex Quadrature Cubature Kalman Filter in Nonlinear Dynamic System
    Hindawi Limited ; 2020
    In:  Mathematical Problems in Engineering Vol. 2020 ( 2020-05-14), p. 1-13
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2020 ( 2020-05-14), p. 1-13
    Abstract: A novel spherical simplex Gauss–Laguerre quadrature cubature Kalman filter is proposed to improve the estimation accuracy of nonlinear dynamic system. The nonlinear Gaussian weighted integral has been approximately evaluated using the spherical simplex rule and the arbitrary order Gauss–Laguerre quadrature rule. Thus, a spherical simplex Gauss–Laguerre cubature quadrature rule is developed, from which the general computing method of the simplex cubature quadrature points and the corresponding weights are obtained. Then, under the nonlinear Kalman filtering framework, the spherical simplex Gauss–Laguerre quadrature cubature Kalman filter is derived. A high-dimensional nonlinear state estimation problem and a target tracking problem are utilized to demonstrate the effectiveness of the proposed spherical simplex Gauss–Laguerre cubature quadrature rule to improve the performance.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2020/1072824
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 10
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    Online Resource
    Fiber selectivity of peripheral neuropathy in patients with Parkinson's disease
    Hindawi Limited ; 2022
    In:  Acta Neurologica Scandinavica Vol. 146, No. 1 ( 2022-07), p. 75-81
    Details
    In: Acta Neurologica Scandinavica, Hindawi Limited, Vol. 146, No. 1 ( 2022-07), p. 75-81
    Type of Medium: Online Resource
    ISSN: 0001-6314 , 1600-0404
    URL: Issue
    URL: Article
    DOI: 10.1111/ane.v146.1
    DOI: 10.1111/ane.13624
    RVK:
    XA 10000
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2001898-8
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