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  • Online Resource  (2)
  • 2020-2024  (2)
  • 2024  (2)
  • 1
    In: Schizophrenia Bulletin, Oxford University Press (OUP), ( 2024-06-07)
    Abstract: Schizophrenia (SCZ) and anorexia nervosa (AN) are 2 severe and highly heterogeneous disorders showing substantial familial co-aggregation. Genetic factors play a significant role in both disorders, but the shared genetic etiology between them is yet to be investigated. Study Design Using summary statistics from recent large genome-wide association studies on SCZ (Ncases = 53 386) and AN (Ncases = 16 992), a 2-sample Mendelian randomization analysis was conducted to explore the causal relationship between SCZ and AN. MiXeR was employed to quantify their polygenic overlap. A conditional/conjunctional false discovery rate (condFDR/conjFDR) framework was adopted to identify loci jointly associated with both disorders. Functional annotation and enrichment analyses were performed on the shared loci. Study Results We observed a cross-trait genetic enrichment, a suggestive bidirectional causal relationship, and a considerable polygenic overlap (Dice coefficient = 62.2%) between SCZ and AN. The proportion of variants with concordant effect directions among all shared variants was 69.9%. Leveraging overlapping genetic associations, we identified 6 novel loci for AN and 33 novel loci for SCZ at condFDR & lt;0.01. At conjFDR & lt;0.05, we identified 10 loci jointly associated with both disorders, implicating multiple genes highly expressed in the cerebellum and pituitary and involved in synapse organization. Particularly, high expression of the shared genes was observed in the hippocampus in adolescence and orbitofrontal cortex during infancy. Conclusions This study provides novel insights into the relationship between SCZ and AN by revealing a shared genetic component and offers a window into their complex etiology.
    Type of Medium: Online Resource
    ISSN: 0586-7614 , 1745-1701
    RVK:
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
    detail.hit.zdb_id: 2180196-4
    SSG: 15,3
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  • 2
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 12 ( 2024-7-11)
    Abstract: Due to tectonic uplift in the Cenozoic and numerous shelf-wide glaciations during the Quaternary, ∼1–2.5 km of sedimentary overburden has been eroded from the Barents Sea shelf, leading to the exhumation and partial uncapping of hydrocarbon accumulations. Widespread natural gas and oil leakage from the glacially eroded middle-upper Triassic reservoir directly into the water column has been documented at the Sentralbanken high in the northern Norwegian Barents Sea. However, it remains unclear whether the hydrocarbon leakage occurs only from the middle-upper Triassic reservoir units in geological settings exceptionally conducive to hydrocarbon leakage, or if other reservoir formations contributed to the release of hydrocarbons into the water column. It is also not clear whether complete erosion of the caprock is a prerequisite for widespread liberation of natural gas and oil from glacially eroded reservoirs across Arctic continental shelves. Here we analyze multibeam echosounder data covering ∼5,000 km 2 and a suite of high-resolution P-cable seismic lines from a range of geological structures across the northern Norwegian Barents Sea. Our analyses reveal that ∼21,700 natural gas seeps originate from exhumed, faulted and variably eroded structural highs bearing a range of Mesozoic reservoir formations. All investigated structural highs fuel seabed methane release hotspots with no exception. Evident from observations of seismic anomalies, fluid accumulations are pervasive in the subsurface and likely to continue fuelling seabed gas seepage into the future. We also document that gas seepage through faults piercing overburden, caprocks and reaching potential reservoir levels is pervasive at all investigated structural highs. On the Storbanken high and the Kong Karl platform, such fault-controlled seepage is more prevalent than seepage from reservoir formations subcropping below the seafloor. Using a simple parametrization approach, we estimate that seeps identified within our multibeam data coverage produce a seabed methane flux of 61 x 10 7 mol/yr (9,803 ton/yr), which is one to two orders of magnitude higher than other globally known submarine methane seepage provinces. Fluxes of methane from sea water to the air above the thermogenic gas seep provinces in the northern Norwegian Barents Sea remain to be determined.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2741235-0
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