In:
Scandinavian Journal of Immunology, Wiley, Vol. 52, No. 6 ( 2000-12), p. 555-562
Abstract:
The T‐cell repertoire is shaped by the positive and negative selection of immature CD4 + CD8 + double positive (DP) thymocytes. Positive selection of DP T cells to the CD4 + CD8 − and CD4 − CD8 + simple positive (SP) lineages is a multistep process which involves cellular interactions between thymocytes and stromal cells. Mutant nackt (nkt/nkt) mice have been shown to have a deficiency in the CD4 + CD8 − T‐cell subset both in the thymus and in the periphery . The present report suggests that nkt/nkt mice present alterations in early steps of positive selection because they show decreases in the percentages of CD69 + and CD5 + cells within the DP subset. Experiments involving bone marrow transfer and thymic chimeras demonstrate that the thymic epithelium of nkt/nkt mice is involved in the alterations registered during positive selection and dictates the ultimate fate of CD4 + SP cells.
Type of Medium:
Online Resource
ISSN:
0300-9475
,
1365-3083
DOI:
10.1111/sji.2000.52.issue-6
DOI:
10.1111/j.1365-3083.2000.00818.x
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
2020954-X
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