In:
Nuclear Medicine Communications, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 12 ( 2022-12), p. 1239-1246
Abstract:
To assess the prognostic value of PET/computed tomography-based parameters in patients with locally advanced esophageal squamous cell carcinoma (ESSC). Methods Sixty-seven patients with ESSC undergoing definitive chemoradiotherapy (dCRT) were retrospectively enrolled. PET/CT parameters (maximum standardized uptake value (SUV max ) metabolic tumor volume (MTV), and total glycolysis (TLG) were obtained from 18 F-fluorodeoxyglucose ( 18 F-FDG) PET/CT studies. The correlation between overall survival and PET/CT parameters was analyzed using a Cox proportional hazards model. Results There were no differences in TLG, MTV, and SUV max values across age, sex, tumor location, and lymph node status. However, for patients with cT3-4 disease, TLG and SUV max were significantly higher ( P = 0.019 and P = 0.018, respectively), and MTV showed an increasing trend ( P = 0.068). There were significant correlations among TLG, MTV and SUV max . According to the receiver-operating curve, the cutoff values of TLG, MTV and SUV max dichotomized by survival status at 2 years were 64.00 g, 9.63 ml and 9.97 g/ml, respectively. In univariate analysis, increased TLG, MTV and SUV max were significant negative prognostic factors for OS. However, in multivariate analysis, only SUV max was an independent prognostic factor for overall survival (hazard ratios = 2.857, 95% confidence intervals: 1.837–4.442; P = 0.017). Conclusions PET/CT is a useful tool for predicting the prognoses in patients with locally advanced ESSC treated with dCRT. Future prospective studies with a large number of samples should be conducted to confirm these results.
Type of Medium:
Online Resource
ISSN:
0143-3636
DOI:
10.1097/MNM.0000000000001619
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2022
detail.hit.zdb_id:
758141-5
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