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  • Online Resource  (83)
  • Wiley  (83)
  • Sun, Kai  (83)
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  • Wiley  (83)
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  • 1
    In: Epilepsia, Wiley, Vol. 60, No. 12 ( 2019-12), p. 2519-2529
    Abstract: Temporal lobe epilepsy is a common form of epilepsy that might be amenable to surgery. However, magnetic resonance imaging (MRI)‐negative hippocampal sclerosis (HS) can hamper early diagnosis and surgical intervention for patients in clinical practice, resulting in disease progression. Our aim was to automatically detect and evaluate the structural alterations of HS. Methods Eighty patients with pharmacoresistant epilepsy and histologically proven HS and 80 healthy controls were included in the study. Two automated classifiers relying on clinically empirical and radiomics features were developed to detect HS. Cross‐validation was implemented on all participants, and specificity was assessed in the 80 controls. The performance, robustness, and clinical utility of the model were also evaluated. Structural analysis was performed to investigate the morphological abnormalities of HS. Results The computational model based on clinical empirical features showed excellent performance, with an area under the curve (AUC) of 0.981 in the primary cohort and 0.993 in the validation cohort. One of the features, gray‐white matter boundary blurring in the temporal pole, exhibited the highest weight in model performance. Another model based on radiomics features also showed satisfactory performance, with AUC of 0.997 in the primary cohort and 0.978 in the validation cohort. In particular, the model improved the detection rate of MRI‐negative HS to 96.0%. The novel feature of cortical folding complexity of the temporal pole not only played a crucial role in the classifier but also had significant correlation with disease duration. Significance Machine learning with quantitative clinical and radiomics features is shown to improve HS detection. HS‐related structural alterations were similar in the MRI‐positive and MRI‐negative HS patient groups, indicating that misdiagnosis originates mainly from empirical interpretation. The cortical folding complexity of the temporal pole is a potentially valuable feature for exploring the nature of HS.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2002194-X
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  • 2
    In: Clinical Otolaryngology, Wiley, Vol. 49, No. 4 ( 2024-07), p. 404-416
    Abstract: Laryngeal leukoplakia (LL) is a white lesion with high potential of recurrence and malignant transformation. Currently, CO 2 laser has become the primary surgical treatment for LL, and the recurrence and malignant transformation rates after treatment vary widely. Objective We performed a systematic review and meta‐analysis dedicated to evaluating the rates of recurrence and malignant transformation of LL lesions treated with CO 2 laser and exploring relevant risk factors for recurrence or malignant transformation. Methods Literature searches were conducted on ProQuest, PubMed, Web of Science, Ovid Medline, Embase, and Cochrane databases. Some articles identified through hand searching were included. Results A total of 14 articles and 1462 patients were included in this review. Pooled results showed that the overall recurrence rate was 15%, and the malignant transformation rate was 3%. Subgroup analysis showed that the dysplasia grade was not a significant risk factor for the recurrence and malignant transformation of LL ( P 〉 .05). Conclusions The results of this systematic review and meta‐analysis suggest that the CO 2 laser is a safe and effective surgical instrument for the excision of LL, which yields low rates of recurrence and malignant transformation. The risk factors relevant to recurrence or malignant transformation remain unclear and require further investigation.
    Type of Medium: Online Resource
    ISSN: 1749-4478 , 1749-4486
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2206071-6
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  • 3
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 16, No. 2 ( 2023-06), p. 246-258
    Abstract: Frozen shoulder is a common disorder that can lead to long‐lasting impairment in shoulder‐related daily activities. Traditional Chinese medicine (TCM) has played an important role in the effort to manage frozen shoulder. Purpose We aimed to develop an evidence‐based guideline for treating frozen shoulder with traditional Chinese medicine. Study design Evidence‐based guideline. Methods We developed this guideline based on internationally recognized and accepted guideline standards. The guideline development group used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to rate the certainty of evidence and the strength of recommendations. The benefits and harms, resources, accessibility, and other factors were fully taken into account, and the GRADE grid method was used to reach consensus on all recommendations. Results We established a multidisciplinary guideline development panel. Based on a systematic literature search and a face‐to‐face meeting, nine clinical questions were identified. Finally, twelve recommendations were reached by consensus, comprehensively considering the balance of benefits and harms, certainty of evidence, costs, clinical feasibility, accessibility, and clinical acceptability. Conclusion This guideline panel made twelve recommendations, which covered the use of manual therapy, acupuncture, needle knife, Cheezheng Xiaotong plaster, Gutong plaster, exercise therapy and integrated TCM and Western medicine, such as combined modalities and corticosteroid injections. Most of them were weakly recommended or consensus based. The users of this guideline are most likely to be clinicians and health administrators.
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2474496-7
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  • 4
    In: Pacing and Clinical Electrophysiology, Wiley, Vol. 41, No. 3 ( 2018-03), p. 246-254
    Abstract: Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) is known to induce left atrial remodeling and prothrombotic response. Aims This study aimed to evaluate the effect of remote ischemic preconditioning (RIPC) on left atrial remodeling and prothrombotic response induced by RFCA of AF. Methods Forty‐four patients with drug‐refractory paroxysmal AF undergoing RFCA were randomized into RIPC (four short episodes of forearm ischemia) and control groups before the procedure. Blood samples were collected before RIPC/sham RIPC, and 24 and 72 hours later after the procedure. The atrial remodeling marker matrix metalloproteinase‐9 (MMP‐9) and endothelial damage marker von Willebrand factor (vWF) were measured using enzyme‐linked immunosorbent assay. Platelet activation was evaluated by flow cytometric measurements of the expression of platelet P‐selectin (CD62P) and active glycoprotein IIb/IIIa receptor (PAC‐1). The early recurrence of atrial fibrillation (ERAF) in the two groups was observed over the subsequent 3 months. Results RFCA resulted in a significant increase in MMP‐9 and vWF in both the groups, which persisted for 72 hours. However, the expression of CD62P and PAC‐1 showed less increase during RFCA in either group. The RIPC group showed a lower increase in MMP‐9 and vWF compared with the control group. In contrast, no significant differences were found in the trend of expression of CD62P and PAC‐1 during RFCA between the two groups. The AF recurrence in the 3 months after the ablation was significantly lower in the RIPC group than in the control group. Conclusions RIPC before RFCA for paroxysmal AF significantly reduces the increase in markers of left atrial remodeling and endothelial damage associated with the procedure, and results in a lower ERAF.
    Type of Medium: Online Resource
    ISSN: 0147-8389 , 1540-8159
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2037547-5
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  • 5
    In: Journal of Plant Nutrition and Soil Science, Wiley, Vol. 182, No. 3 ( 2019-06), p. 429-440
    Abstract: Long‐term no‐tillage management and crop residue amendments to soil were identified as an effective measure to increase soil organic carbon (SOC). The SOC content, SOC stock (SOCs), soil carbon sequestration rate (CSR), and carbon pool management index (CPMI) were measured. A stable isotopic approach was used to evaluate the contributions of wheat and maize residues to SOC at a long‐term experimental site. We hypothesized that under no‐tillage conditions, straw retention quantity would affect soil carbon sequestration differently in surface and deep soil, and the contribution of C3 and C4 crops to soil carbon sequestration would be different. This study involved four maize straw returning treatments, which included no maize straw returning (NT‐0), 0.5 m (from the soil surface) maize straw returning (NT‐0.5), 1 m maize straw returning (NT‐1), and whole maize straw returning (NT‐W). The results showed that in the 0–20 cm soil layer, the SOC content, SOCs, CSR and CPMI of the NT‐W were highest after 14 years of no‐tillage management, and there were obvious differences among the four treatments. However, the SOC, SOCs, and CSR of the NT‐0.5 and NT‐W were the highest and lowest in 20–100 cm, respectively. The value of δ 13 C showed an obviously vertical variability that ranged from –22.01‰ (NT‐1) in the 0–20 cm layer to –18.27‰ (NT‐0.5) in the 60–80 cm layer, with enriched δ 13 C in the 60–80 cm (NT‐0.5 and NT‐1) and 80–100 cm (NT‐0 and NT‐W) layers. The contributions of the wheat and maize‐derived SOC of the NT‐0.5, NT‐1 and NT‐W increased by 11.4, 29.5 and 56.3% and by 10.7, 15.1 and 40.1%, relative to those in the NT‐0 treatment in the 0–20 cm soil layer, respectively. In conclusion, there was no apparent difference in total SOC sequestration between the NT‐0.5, NT‐1, and NT‐W treatments in the 0–100 cm soil layer. The contribution of wheat‐derived SOC was higher than that of maize‐derived SOC.
    Type of Medium: Online Resource
    ISSN: 1436-8730 , 1522-2624
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1481142-X
    detail.hit.zdb_id: 1470765-2
    detail.hit.zdb_id: 200063-5
    SSG: 12
    SSG: 13
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  • 6
    In: Journal of Cellular Biochemistry, Wiley, Vol. 120, No. 3 ( 2019-03), p. 3071-3081
    Abstract: The soluble form of guanylyl cyclase (sGC) is the main receptor for the signaling agent nitric oxide (NO), which regulates cardiomyocyte contractile function and attenuates cardiomyocyte hypertrophy. sGC catalyzes the formation of cyclic guanosine monophosphate (cGMP), a regulator of vascular tone, and cardiac NO‐sGC‐cGMP signaling modulates cardiac stress responses, including ischemia and reperfusion (IR) injury. Here, we investigated the role of GUCY1B3 (the β subunit of sGC) in cardiomyocyte IR injury and myocardial infarction (MI) in vitro and in vivo. GUCY1B3 was upregulated in neonatal rat ventricular myocytes in response to IR injury, and GUCY1B3 overexpression restored IR‐induced cell death and apoptosis. Treatment with specific inhibitors of PKCδ, PKCε, and Akt suggested that the protective effects of GUCY1B3 were mediated by PKCε/Akt signaling. In a mouse model of coronary artery ligation‐induced MI, GUCY1B3 silencing aggravated MI‐induced cardiac dysfunction and increased infarct size and exacerbated cardiomyocyte apoptosis in association with the inactivation of PKCε and Akt. Our results suggest that GUCY1B3 exerts cardioprotective effects through the modulation of the PKCε/Akt activity and identify a potential mechanism involved in NO‐sGC‐cGMP signaling in the heart.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 7
    In: Chinese Journal of Chemistry, Wiley, Vol. 34, No. 12 ( 2016-12), p. 1309-1320
    Abstract: A convenient copper‐catalyzed approach has been developed for the synthesis of substituted spiro‐fused pyrazolin‐5‐ones from readily available cyclopropyl O ‐acyl ketoximes via an intramolecular NN bond formation reaction. These catalytic reactions proceed in excellent yields with a broad scope.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2009
    In:  Angewandte Chemie International Edition Vol. 48, No. 23 ( 2009-05-25), p. 4217-4221
    In: Angewandte Chemie International Edition, Wiley, Vol. 48, No. 23 ( 2009-05-25), p. 4217-4221
    Abstract: Shape‐controlled catalysis : High‐quality Pt–Cu nanocubes with an average size of about 8 nm (see picture, scale bar=20 nm) were synthesized from a high‐temperature organic solution system in the presence of various capping ligands. These cubic Pt–Cu nanocrystals terminated with {100} facets demonstrated a superior catalytic activity towards methanol oxidation compared to similar sized Pt–Cu and Pt nanospheres. magnified image
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 9
    In: Small, Wiley, Vol. 15, No. 40 ( 2019-10)
    Abstract: Lithium–sulfur batteries (LSBs) have shown great potential for application in high‐density energy storage systems. However, the performance of LSBs is hindered by the shuttle effect and sluggish reaction kinetics of lithium polysulfides (LiPSs). Herein, heterostructual Nb 2 O 5 nanocrystals/reduced graphene oxide (Nb 2 O 5 /RGO) composites are introduced into LSBs through separator modification for boosting the electrochemical performance. The Nb 2 O 5 /RGO heterostructures are designed as chemical trappers and conversion accelerators of LiPSs. Originating from the strong chemical interactions between Nb 2 O 5 and LiPSs as well as the superior catalytic nature of Nb 2 O 5 , the Nb 2 O 5 /RGO nanocomposite possesses high trapping efficiency and efficient electrocatalytic activity to long‐chain LiPSs. The effective regulation of LiPSs conversion enables the LSBs enhanced redox kinetics and suppressed shuttle effect. Moreover, the Nb 2 O 5 /RGO nanocomposite has abundant sulfophilic sites and defective interfaces, which are beneficial for the nucleation and growth of Li 2 S, as evidenced by analysis of the cycled separators. As a result, LSBs with the Nb 2 O 5 /RGO‐modified separators exhibit excellent rate capability (816 mAh g −1 at 3 A g −1 ) and cyclic performance (628 mAh g −1 after 500 cycles). Remarkably, high specific capacity and stable cycling performance are demonstrated even at an elevated temperature of 50 °C or with higher sulfur loadings.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2168935-0
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  • 10
    In: ChemInform, Wiley, Vol. 47, No. 27 ( 2016-06)
    Abstract: A novel route towards pyrroloquinolinones via direct intramolecular amide arylation is developed.
    Type of Medium: Online Resource
    ISSN: 0931-7597 , 1522-2667
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2110203-X
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