In:
Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 16, No. 7 ( 2019-06-27), p. 785-791
Abstract:
In recent years, pyrazole carboxamide derivatives possessed excellent
fungicidal activity. In the process of designing n ew fungicides, the carboxamide group was modified
in order to find novel structure pyrazole carboxamide derivatives. Methods: Ten novel trifluoromethyl pyrazole acyl thiourea derivatives were designed and synthesized.
In vivo fungicidal activities of these compounds were tested against Fusarium oxysporum, Corynespora mazei and Botrytis cinerea, respectively Results: Particularly compounds exhibited significant control effective at 100 mg/L. More importantly,
some compounds showed the good control effective at 10 mg/L. Furthermore, docking was established to study the structure-activity relationship of the title compounds. Conclusion: It is possible that trifluoromethylpyrazole acyl thiurea derivatives, which possess good
control effective against Botrytis cinerea, may become novel lead compounds for the development of fungicides with further structure modification.
Type of Medium:
Online Resource
ISSN:
1570-1808
DOI:
10.2174/1570180815666180704103047
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2019
SSG:
15,3
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