In:
Frontiers in Chemistry, Frontiers Media SA, Vol. 10 ( 2022-2-15)
Abstract:
Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E ( 1 ) and F ( 2 ), one new chromone fusarimone A ( 5 ), two new benzofurans fusarifurans A ( 9 ) and B ( 10 ), three new isocoumarins fusarimarins A–C ( 11–13 ), as well as five known analogues 3 , 4 , 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC 50 values of 8.7 and 4.3 μM, respectively.
Type of Medium:
Online Resource
ISSN:
2296-2646
DOI:
10.3389/fchem.2022.842405
DOI:
10.3389/fchem.2022.842405.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2711776-5
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