In:
Journal of International Medical Research, SAGE Publications, Vol. 19, No. 1 ( 1991-01), p. 39-43
Abstract:
A double-blind, crossover study was carried out on the antihypertensive effect of 5 mg ramipril. Continuous 24-h blood pressure monitoring was performed on 15 essential hypertensives [mean (± SD) blood pressure 155.2 ± 6.5/101.3 ± 4.8 mmHg] , 24 h prior to treatment and 48 h after having received either antihypertensive therapy or placebo; the patients taking part in the study had not taken any antihypertensive treatment 4 weeks prior to the beginning of the trial. After receiving 5 mg ramipril the mean 24-h blood pressure was significantly ( P 〈 0.05) reduced to 148.3 ± 5.8/91.5 ± 5.5 mmHg. After 48 h the blood pressure increased to 153.1 ± 4.8/96.0 ± 6.4 mmHg. In the placebo group there was only a slight, non-significant reduction in blood pressure on day 1 (154.3 ± 6.9/97.3 ± 5.7 mmHg) and during day 2 the blood pressure increased to 155.4 ± 5.3/99.5 ± 5.9 mmHg. The results showed that a once-daily administration of 5 mg ramipril produced a reduction in blood pressure, which lasted 24 h. This simple therapeutic regime offers the advantage of being easy for patients to follow and, therefore, promotes compliance with therapy.
Type of Medium:
Online Resource
ISSN:
0300-0605
,
1473-2300
DOI:
10.1177/030006059101900105
Language:
English
Publisher:
SAGE Publications
Publication Date:
1991
detail.hit.zdb_id:
2082422-1
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