In:
Diabetes, American Diabetes Association, Vol. 42, No. 10 ( 1993-10-01), p. 1520-1527
Abstract:
Because of islet allograft rejection, nonimmunosuppressed pancreatic islet allotransplantation has been unsuccessful for the treatment of type I diabetes. The role of major histocompatibility complex class I antigen expression on islet allograft survival was evaluated with the use of mice homozygous for a β2-microglobulin gene disruption. These mice express little if any functional major histocompatibility complex class I antigen. When these major histocompatibility complex class I-deficient islets were used as donors in an allogenic murine transplantation model, islet allograft survival was markedly prolonged. These results demonstrate a major importance for the alloresponse directed against major histocompatibility complex class I antigen.
Type of Medium:
Online Resource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diab.42.10.1520
Language:
English
Publisher:
American Diabetes Association
Publication Date:
1993
detail.hit.zdb_id:
80085-5
detail.hit.zdb_id:
1501252-9
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