In:
Open Biology, The Royal Society, Vol. 8, No. 10 ( 2018-10)
Abstract:
Paraspeckles are nuclear bodies built on an architectural long noncoding RNA, NEAT1, and a series of studies have revealed their molecular components, fine internal structures and cellular and physiological functions. Emerging lines of evidence suggest that paraspeckle formation is elicited by phase separation of associating RNA-binding proteins containing intrinsically disordered regions, which induce ordered arrangement of paraspeckle components along NEAT1. In this review, we will summarize the history of paraspeckle research over the last couple of decades, especially focusing on the function and structure of the nuclear bodies. We also discuss the future directions of research on long noncoding RNAs that form ‘RNP milieux’, large and flexible phase-separated ribonucleoprotein complexes.
Type of Medium:
Online Resource
ISSN:
2046-2441
Language:
English
Publisher:
The Royal Society
Publication Date:
2018
detail.hit.zdb_id:
2630944-0
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