GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Online Resource  (6)
  • Wiley  (6)
  • Li, Bingjie  (6)
Material
  • Online Resource  (6)
Publisher
  • Wiley  (6)
Person/Organisation
Language
Years
Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    A Minimalist Iron Oxide Nanoprobe for the High‐Resolution Depiction of Stroke by Susceptibility‐Weighted Imaging
    Wiley ; 2024
    In:  Small
    Details
    In: Small, Wiley
    Abstract: The precise mapping of collateral circulation and ischemic penumbra is crucial for diagnosing and treating acute ischemic stroke (AIS). Unfortunately, there exists a significant shortage of high‐sensitivity and high‐resolution in vivo imaging techniques to fulfill this requirement. Herein, a contrast enhanced susceptibility‐weighted imaging (CE‐SWI) using the minimalist dextran‐modified Fe 3 O 4 nanoparticles (Fe 3 O 4 @Dextran NPs) are introduced for the highly sensitive and high‐resolution AIS depiction under 9.4 T for the first time. The Fe 3 O 4 @Dextran NPs are synthesized via a simple one‐pot coprecipitation method using commercial reagents under room temperature. It shows merits of small size (hydrodynamic size 25.8 nm), good solubility, high transverse relaxivity ( r 2 ) of 51.3 mM −1 s −1 at 9.4 T, and superior biocompatibility. The Fe 3 O 4 @Dextran NPs‐enhanced SWI can highlight the cerebral vessels readily with significantly improved contrast and ultrahigh resolution of 0.1 mm under 9.4 T MR scanner, enabling the clear spatial identification of collateral circulation in the middle cerebral artery occlusion (MCAO) rat model. Furthermore, Fe 3 O 4 @Dextran NPs‐enhanced SWI facilitates the precise depiction of ischemia core, collaterals, and ischemic penumbra post AIS through matching analysis with other multimodal MR sequences. The proposed Fe 3 O 4 @Dextran NPs‐enhanced SWI offers a high‐sensitivity and high‐resolution imaging tool for individualized characterization and personally precise theranostics of stroke patients.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Article
    DOI: 10.1002/smll.202401061
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2168761-4
    detail.hit.zdb_id: 2168935-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    One‐Minute Preparation of Iron Foam‐Drug Implant for Ultralow‐Power Magnetic Hyperthermia‐Based Combination Therapy of Tumors in Vivo
    Wiley ; 2024
    In:  Advanced Science Vol. 11, No. 11 ( 2024-03)
    Details
    In: Advanced Science, Wiley, Vol. 11, No. 11 ( 2024-03)
    Abstract: The magnetic hyperthermia‐based combination therapy (MHCT) is a powerful tumor treatment approach due to its unlimited tissue penetration depth and synergistic therapeutic effect. However, strong magnetic hyperthermia and facile drug loading are incompatible with current MHCT platforms. Herein, an iron foam (IF)‐drug implant is established in an ultra‐facile and universal way for ultralow‐power MHCT of tumors in vivo for the first time. The IF‐drug implant is fabricated by simply immersing IF in a drug solution at an adjustable concentration for 1 min. Continuous metal structure of IF enables ultra‐high efficient magnetic hyperthermia based on eddy current thermal effect, and its porous feature provides great space for loading various hydrophilic and hydrophobic drugs via “capillary action”. In addition, the IF has the merits of low cost, customizable size and shape, and good biocompatibility and biodegradability, benefiting reproducible and large‐scale preparation of IF‐drug implants for biological application. As a proof of concept, IF‐doxorubicin (IF‐DOX) is used for combined tumor treatment in vivo and achieves excellent therapeutic efficacy at a magnetic field intensity an order of magnitude lower than the threshold for biosafety application. The proposed IF‐drug implant provides a handy and universal method for the fabrication of MHCT platforms for ultralow‐power combination therapy.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v11.11
    DOI: 10.1002/advs.202307823
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2808093-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    NOTCH 4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case‐control study
    Wiley ; 2018
    In:  Journal of Clinical Laboratory Analysis Vol. 32, No. 6 ( 2018-07)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 32, No. 6 ( 2018-07)
    Abstract: The incidence of dilated cardiomyopathy ( DCM ) has increased in recent years, and many studies have sought to further improve the general understanding of this condition. Previous studies have demonstrated that some single nucleotide polymorphisms ( SNP s) associated with systemic lupus erythematosus also affect susceptibility to DCM , suggesting that immune‐related diseases may share similar genetic susceptibility. Recent large‐scale and genome‐wide association studies have identified NCR 3 , NOTCH 4 , CYP 1A2 , ITGA 1 , OPRM 1 , ST 8 SIA 2 , and LINC 00704 as genetic risk factors associated with cardiac manifestations of neonatal lupus. Here, we aimed to determine whether these SNP s conferred susceptibility to DCM in the Chinese Han population. Methods We investigated the relationship between these polymorphisms and DCM risk in 273 patients with DCM and 548 healthy controls. Genotyping was performed using MassArray iPLEX system. Results Logistic regression analysis indicated that the T allele of rs3134942 in NOTCH 4 gene increased the risk of DCM by 61% compared with the G allele ( P a  = 6.57 × 10 −3 ). The SNP rs3134942 was also significantly associated with increased DCM risk in the additive ( P a  = 6.57 × 10 −3 ) and dominant models ( P a  = 1.01 × 10 −2 ). Additionally, rs2472299 in CYP 1A2 gene showed suggestive association with reduced risk of DCM in the dominant model ( P a  = 4.24 × 10 −2 ) and was correlated with smoking status in patients with DCM ( P a  = 1.56 × 10 −2 ). Conclusions Our findings suggested that rs3134942 in NOTCH 4 may be involved in DCM risk. Further, studies in larger and ethnically diverse populations are required to confirm the results reported in this study.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2018.32.issue-6
    DOI: 10.1002/jcla.22436
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2001635-9
    detail.hit.zdb_id: 645095-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Characterization of a non‐coding RNA‐associated ceRNA network in metastatic lung adenocarcinoma
    Wiley ; 2020
    In:  Journal of Cellular and Molecular Medicine Vol. 24, No. 20 ( 2020-10), p. 11680-11690
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 24, No. 20 ( 2020-10), p. 11680-11690
    Abstract: Lung adenocarcinoma (LUAD) is a highly malignant cancer. Although competing endogenous RNA (ceRNA)‐based profiling has been investigated in patients with LUAD, it has not been specifically used to study metastasis in LUAD. We found 130 differentially expressed (DE) lncRNAs, 32 DE miRNAs and 981 DE mRNAs from patients with LUAD in The Cancer Genome Atlas (TCGA) database. We analysed the functions and pathways of 981 DE mRNAs using the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Based on the target DE mRNAs and DE lncRNAs of DE miRNAs, we established an lncRNA‐miRNA‐mRNA ceRNA network, comprising 37 DE lncRNAs, 22 DE miRNAs and 212 DE mRNAs. Subsequently, we constructed a protein‐protein interaction network of DE mRNAs in the ceRNA network. Among all, DE RNAs, 5 DE lncRNAs, 5 DE miRNAs and 45 DE mRNAs were confirmed found to be associated with clinical prognosis. Moreover, 3 DE lncRNAs, 4 DE miRNAs and 9 DE mRNAs in the ceRNA network were associated with clinical prognosis. We further screened 3 DE lncRNAs, 3 DE miRNAs and 3 DE mRNAs using clinical samples. These DE lncRNAs, DE miRNAs and DE mRNAs in ceRNA network may serve as independent biomarkers of LUAD metastasis.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v24.20
    DOI: 10.1111/jcmm.15778
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2076114-4
    detail.hit.zdb_id: 2074559-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Full‐Color Holographic Display and Encryption with Full‐Polarization Degree of Freedom
    Wiley ; 2022
    In:  Advanced Materials Vol. 34, No. 3 ( 2022-01)
    Details
    In: Advanced Materials, Wiley, Vol. 34, No. 3 ( 2022-01)
    Abstract: Metasurfaces provide a compact and powerful platform for manipulating the fundamental properties of light, and have shown unprecedented capabilities in both optical holographic display and information encryption. For increasing information display/storage capacity, metasurfaces with more polarization manipulation channel and full‐color holographic functionality are now an urgent requirement. Here, a minimalist dielectric metasurface with the capability of full‐color holography encoded with arbitrary polarization is proposed and experimentally demonstrated. Without the daunting exploratory and computational problem in nanostructure searching, full‐color holographic images can be multiplexed into arbitrary polarization channels through vectorial ptychography and k ‐space ptychography based on tetratomic macropixel geometric phase metasurfaces. Thanks to the full degree of freedom tuning in polarization and color spaces, the application scenarios such as holographic 3D imaging and information encryption are realized. The strategy exhibits promising potential in applications of 3Dl display, augmented/virtual reality, high‐density data storage, and encryption.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v34.3
    DOI: 10.1002/adma.202103192
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1012489-5
    detail.hit.zdb_id: 1474949-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Adipose‐derived miRNAs as potential biomarkers for predicting adulthood obesity and its complications: A systematic review and bioinformatic analysis
    Wiley ; 2024
    In:  Obesity Reviews Vol. 25, No. 7 ( 2024-07)
    Details
    In: Obesity Reviews, Wiley, Vol. 25, No. 7 ( 2024-07)
    Abstract: Adipose tissue is the first and primary target organ of obesity and the main source of circulating miRNAs in patients with obesity. This systematic review aimed to analyze and summarize the generation and mechanisms of adipose‐derived miRNAs and their role as early predictors of various obesity‐related complications. Literature searches in the PubMed and Web of Science databases using terms related to miRNAs, obesity, and adipose tissue. Pre‐miRNAs from the Human MicroRNA Disease Database, known to regulate obesity‐related metabolic disorders, were combined for intersection processing. Validated miRNA targets were sorted through literature review, and enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes via the KOBAS online tool, disease analysis, and miRNA transcription factor prediction using the TransmiR v. 2.0 database were also performed. Thirty miRNAs were identified using both obesity and adipose secretion as criteria. Seventy‐nine functionally validated targets associated with 30 comorbidities of these miRNAs were identified, implicating pathways such as autophagy, p53 pathways, and inflammation. The miRNA precursors were analyzed to predict their transcription factors and explore their biosynthesis mechanisms. Our findings offer potential insights into the epigenetic changes related to adipose‐driven obesity‐related comorbidities.
    Type of Medium: Online Resource
    ISSN: 1467-7881 , 1467-789X
    URL: Issue
    URL: Article
    DOI: 10.1111/obr.v25.7
    DOI: 10.1111/obr.13748
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2147980-X
    detail.hit.zdb_id: 2020497-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...