In:
BJU International, Wiley, Vol. 125, No. 1 ( 2020-01), p. 160-167
Abstract:
To evaluate the effectiveness of poloxamer‐based thermo‐sensitive sol–gel instillation, after transurethral resection of the prostate ( TURP ), for preventing urethral stricture. Patients and Methods In all, 198 patients underwent TURP for benign prostatic hyperplasia. Recruited patients were randomly divided into two groups: groups A and B. Patients in Group A (100 patients, experimental group) received poloxamer‐based thermo‐sensitive sol–gel instillation and patients in the Group B (98 patients, control group) received lubricant instillation after TURP . Each patient was evaluated at 4 (V1), 12 (V2), and 24 weeks (V3) after TURP. The effectiveness of poloxamer‐based thermo‐sensitive sol–gel instillation was evaluated based on the International Prostate Symptom Score ( IPSS ), IPSS‐Quality of Life (QoL), Overactive bladder questionnaire ( OAB ‐q), maximum urinary flow rate (Q max ), post‐void residual urine volume ( PVR ), and cystoscopy. Results Amongst the initial 198 participants, 80 patients in Group A and 83 in Group B completed the study. There were no significant differences in IPSS ‐QoL and OAB ‐q between the groups. However, Q max was significantly different between groups A and B, at a mean (SD) of 18.92 (9.98) vs 15.58 (9.24) mL /s ( P = 0.028) at 24 weeks after TURP. On cystoscopic examination, urethral stricture after TURP was found in two of the 80 patients in Group A and 10 of 83 in Group B ( P = 0.023). Conclusions Poloxamer‐based thermo‐sensitive sol–gel instillation after TURP lowered the incidence of urethral stricture.
Type of Medium:
Online Resource
ISSN:
1464-4096
,
1464-410X
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2019983-1
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