In:
Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 23, No. 4 ( 2023-04), p. 558-567
Kurzfassung:
Our primary objective in this study is to determine the relationship
between serum iron (Fe3+) and thyroid functions in type 2 diabetes mellitus (T2DM) patients. Materials and Methods: Glucose metabolic parameters, trace elements, such as Fe3+, and
thyroid functions for 1657 type 2 diabetic patients treated at the Shanghai Pudong Hospital's Department of Endocrinology from 2018 to 2021 were assessed. Results: Variations in free thyroid hormones (FTH) and total thyroid hormones (TTH)
were insignificant; however, thyroid-stimulating hormone (TSH) levels were markedly elevated in patients with positive thyroid peroxidase antibody (TPOAb) and/or positive
antithyroglobulin antibody (TgAb) (p 〈 0.05). Additionally, gender disparities affected
FTH levels (p 〈 0.05) but not TTH and TSH levels. The female gender was significantly
negatively correlated with serum Fe levels (r=-0.381, p 〈 0.05). Serum Fe3+ deficiency
also had an effect on FT3 in both genders, FT4 and TT4 in males (p 〈 0.05), but not TSH
(p 〉 0.05). The multilinear regression model showed that TT3 (β=0.702), eGFR
(β=0.109), Fe3+ (β=0.003), female gender (β=-0.061), and age (β=-0.061) were the major determinants for FT3 change. Moreover, renal function, which was represented as the
estimated glomerular filtration rate (eGFR), had no effects on Fe3+ and TSH levels but on the levels of FTH and TTH (p 〈 0.05). FT3/FT4 exhibited correlations with Fe3+ (r=0.252)
and eGFR (r=0.285). Finally, changes in Fe3+ levels had no significant impact on fasting plasma glucose (FPG), fasting C-peptide, HbA1c, and glycated albumin levels (p 〉 0.05). Conclusions: In addition to age, gender, and renal functions, serum Fe3+ levels in T2DM
patients have a significant relationship with thyroid functions.
Materialart:
Online-Ressource
ISSN:
1871-5303
DOI:
10.2174/1871530322666220928144548
Sprache:
Englisch
Verlag:
Bentham Science Publishers Ltd.
Publikationsdatum:
2023
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