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  • Online Resource  (6)
  • Hu, Huiling  (6)
  • Zhang, Jing  (6)
  • 2020-2024  (6)
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  • Online Resource  (6)
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  • 2020-2024  (6)
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  • 1
    Online Resource
    Online Resource
    The influence of pterygium on corneal densitometry evaluated using the Oculus Pentacam system
    Frontiers Media SA ; 2023
    In:  Frontiers in Medicine Vol. 10 ( 2023-6-15)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 10 ( 2023-6-15)
    Abstract: To assess the effect of pterygium on corneal densitometry (CD) values. Methods One hundred and nine patients (155 eyes) with primary pterygium were divided into a severe pterygium group (79 eyes) and a mild-to-moderate pterygium group (76 eyes) according to pterygium severity. Among them, 63 patients had monocular pterygium; and 25 patients (38 eyes) underwent pterygium excision combined with conjunctival autograft follow-up. A Pentacam anterior segment analyzer was used to obtain the CD values and corneal morphological parameters, including central corneal thickness (CCT), flat-axis keratometry (K1), steep-axis keratometry (K2), corneal astigmatism, irregular astigmatism, and spherical aberration. CD was subdivided into four concentric radial regions based on corneal diameter and three layers according to depth. Results CD values at 0–12 mm of the anterior 120 μm layer, 0–10 mm of the center layer and full thickness, and 2–6 mm of the posterior 60 μm layer were significantly higher in eyes affected by pterygium than in the contralateral unaffected eyes (all P & lt; 0.05). CD values were significantly higher in the severe pterygium group than in the mild to moderate pterygium group (all P & lt; 0.05). Corneal astigmatism, irregular astigmatism, K1, K2, CCT, and spherical aberration correlated with CD values in eyes with pterygium (all P & lt; 0.05). CD values at 6–10, 0–12 mm in the anterior 120 μm layer and full thickness, 10–12 and 0–12 mm in the center layer were significantly decreased 1 month after pterygium surgery compared with those before surgery (all P & lt; 0.05). Conclusion Patients with pterygium had increased CD values, particularly in the anterior and central layers. CD values were correlated with pterygium severity grading and corneal parameters. Pterygium surgery partially reduced the CD values.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    DOI: 10.3389/fmed.2023.1184318
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2775999-4
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  • 2
    Online Resource
    Online Resource
    Insights into CD154‐mediated pathways in ocular hypertensive glaucoma: The role of Müller cells and P2X7 in retinal neuroprotection and therapeutic potential
    Wiley ; 2023
    In:  Cell Biology International Vol. 47, No. 8 ( 2023-08), p. 1441-1452
    Details
    In: Cell Biology International, Wiley, Vol. 47, No. 8 ( 2023-08), p. 1441-1452
    Abstract: An elevation of pathologic intraocular pressure (IOP) is the greatest risk factor for glaucoma. CD154 has been reported to bind to CD40 expressed by orbital fibroblasts and be involved in immune and inflammatory responses. However, the function and mechanism of CD154 in ocular hypertensive glaucoma (OHG) are not fully understood. We isolated and characterized Müller cells and subsequently examined the effect of CD154 on ATP release from those cells. After being cocultured with CD154‐pretreated Müller cells, retinal ganglion cells (RGCs) were treated with P2X7 siRNAs or a P2X7 inhibitor. Furthermore, mouse models of glaucoma (GC) were injected with P2X7 shRNA. p21, p53, and P2X7 expression were examined, and cellular senescence and apoptosis were detected by β‐Gal and TUNEL staining, retinal pathology was examined by H & E staining, and CD154 and β‐Gal expression were detected by ELISA. CD154 induced ATP release from Müller cells and accelerated the senescence and apoptosis of RGCs that had been cocultured with Müller cells. We also found that treatment with P2X7 could attenuate the senescence and apoptosis of RGCs mediated by Müller cells pretreated with CD154. In vivo studies in GC model mice verified that P2X7 silencing attenuated pathological damage and prevented the senescence and apoptosis of retinal tissue. The study demonstrates how CD154 accelerates the aging and apoptosis of RGCs by co‐cultivating Müller cells pretreated with CD154 in OHG. The research implies that CD154 has the potential to become a new therapeutic target for ocular hypertension glaucoma, providing a new research direction for its treatment.
    Type of Medium: Online Resource
    ISSN: 1065-6995 , 1095-8355
    URL: Issue
    URL: Article
    DOI: 10.1002/cbin.v47.8
    DOI: 10.1002/cbin.12030
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1462519-2
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Müller cells under hydrostatic pressure modulate retinal cell survival via TRPV1 / PLCγ1 complex‐mediated calcium influx in experimental glaucoma
    Wiley ; 2024
    In:  The FEBS Journal Vol. 291, No. 12 ( 2024-06), p. 2703-2714
    Details
    In: The FEBS Journal, Wiley, Vol. 291, No. 12 ( 2024-06), p. 2703-2714
    Abstract: Glaucoma, an irreversible blinding eye disease, is currently unclear whose pathological mechanism is. This study investigated how transient receptor potential cation channel subfamily V member 1 (TRPV1), 1‐phosphatidylinositol 4,5‐bisphosphate phosphodiesterase gamma‐1 (PLCγ1), and P2X purinoceptor 7 (P2X7) modulate the levels of intracellular calcium ions (Ca 2+ ) and adenosine triphosphate (ATP) in Müller cells and retinal ganglion cells (RGCs) under conditions of elevated intraocular pressure (IOP). Müller cells were maintained at hydrostatic pressure (HP). TRPV1 ‐ and PLCG1 ‐silenced Müller cells and P2X7 ‐silenced RGCs were constructed by transfection with short interfering RNA (siRNAs). RGCs were cultured with the conditioned media of Müller cells under HP. A mouse model of chronic ocular hypertension (COH) was established and used to investigate the role of TRPV1 in RGCs in vivo . Müller cells and RGCs were analyzed by ATP release assays, intracellular calcium assays, CCK‐8 assays, EdU (5‐ethynyl‐2′‐deoxyuridine) staining, TUNEL staining, flow cytometry, and transmission electron microscopy. In vivo changes in inner retinal function were evaluated by hematoxylin and eosin (H & E) staining and TUNEL staining. Western blot analyses were performed to measure the levels of related proteins. Our data showed that HP increased the levels of ATP and Ca 2+ influx in Müller cells, and those increases were accompanied by the upregulation of TRPV1 and p‐PLCγ1 expression. Suppression of TRPV1 or PLCG1 expression in Müller cells significantly decreased the ATP levels and intracellular Ca 2+ accumulation induced by HP. Knockdown of TRPV1 , PLCG1, or P2X7 significantly decreased apoptosis and autophagy in RGCs cultured in the conditioned media of HP‐treated Müller cells. Moreover, TRPV1 silencing decreased RGC apoptosis and autophagy in the in vivo model of COH. Collectively, inhibition of TRPV1/PLCγ1 and P2X7 expression may be a useful therapeutic strategy for managing RGC death in glaucoma.
    Type of Medium: Online Resource
    ISSN: 1742-464X , 1742-4658
    URL: Issue
    URL: Article
    DOI: 10.1111/febs.v291.12
    DOI: 10.1111/febs.17075
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2172518-4
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Data_Sheet_1.zip
    Frontiers Media SA ; 2021
    In:  Frontiers in Genetics Vol. 12 ( 2021-3-15)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-3-15)
    Abstract: Pterygium is a common ocular surface disease characterized by abnormal fibrovascular proliferation and invasion, similar to tumorigenesis. The formation of tumors is related to a change in the expression of various RNAs; however, whether they are involved in the formation and development of pterygium remains unclear. In this study, transcriptome analysis of messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) of paired pterygium and normal conjunctiva was performed to explore key genes regulating the development of pterygium. In total, 579 mRNAs, 275 lncRNAs, and 21 circRNAs were differentially expressed (DE) in pterygium compared with paired conjunctival tissues. Functional enrichment analysis indicated that DE RNAs were associated with extracellular matrix organization, blood vessel morphogenesis, and focal adhesion. Furthermore, through protein-protein interaction network and mRNA-lncRNA co-expression network analysis, key mRNAs including FN1 , VCAM1 , and MMP2 , and key lncRNAs including MIR4435-2HG and LINC00968 were screened and might be involved in the pathogenesis of pterygium. In addition, several circRNAs including hsa_circ_0007482 and hsa_circ_001730 were considered to be involved in the pterygium development. This study provides a scientific basis for elucidating the pathogenesis of pterygium and will be beneficial for the development of preventive and therapeutic strategies.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2021.646550
    DOI: 10.3389/fgene.2021.646550.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606823-0
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  • 5
    Online Resource
    Online Resource
    Age-related changes in Scheimpflug corneal densitometry and their correlations with corneal topographic measurements in a healthy Chinese population
    AME Publishing Company ; 2023
    In:  Quantitative Imaging in Medicine and Surgery Vol. 13, No. 3 ( 2023-3), p. 1631-1641
    Details
    In: Quantitative Imaging in Medicine and Surgery, AME Publishing Company, Vol. 13, No. 3 ( 2023-3), p. 1631-1641
    Type of Medium: Online Resource
    ISSN: 2223-4292 , 2223-4306
    URL: Journal
    URL: Article
    DOI: 10.21037/qims
    DOI: 10.21037/qims-22-486
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2023
    detail.hit.zdb_id: 2653586-5
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  • 6
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    Online Resource
    Visual function assessment of posterior-chamber phakic implantable collamer lenses with a central port
    AME Publishing Company ; 2022
    In:  Annals of Translational Medicine Vol. 10, No. 4 ( 2022-2), p. 194-194
    Details
    In: Annals of Translational Medicine, AME Publishing Company, Vol. 10, No. 4 ( 2022-2), p. 194-194
    Type of Medium: Online Resource
    ISSN: 2305-5839 , 2305-5847
    URL: Journal
    URL: Article
    DOI: 10.21037/atm
    DOI: 10.21037/atm-22-107
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2022
    detail.hit.zdb_id: 2893931-1
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