In:
Journal of Personalized Medicine, MDPI AG, Vol. 11, No. 9 ( 2021-09-03), p. 883-
Kurzfassung:
Background: Although ABCA1 gene polymorphisms may be associated with the plasma lipid concentration, the literature has not shown a consistent pattern. In this study, we attempted to elucidate the association between the ABCA1 69C 〉 T, 825V 〉 I, and 230R 〉 C polymorphisms and the plasma lipid concentration through a systematic review and meta-analysis. Methods: We selected studies published up to October 2020 in the PubMed, Web of Science, and Embase databases according to inclusion and exclusion criteria. The mean difference (MD) and 95% confidence interval (CI) were used to assess the relationship between the presence of ABCA1 69C 〉 T, 825V 〉 I, and 230R 〉 C and plasma lipid levels. Meta-analysis was performed using Review Manager (version 5.3). Both Begg’s test and Egger’s regression test of the funnel plot were performed using R Studio software (version 3.6.0) to identify publication bias. Results: We analyzed the data on the ABCA1 69C 〉 T polymorphism involving 14,843 subjects in 11 studies, 825V 〉 I polymorphism involving 2580 subjects in 5 studies, and 230R 〉 C polymorphism involving 4834 subjects in 4 studies. The T allele carriers in 69C 〉 T, II carriers in 825V 〉 I, and C carriers in 230R 〉 C had lower high-density lipoprotein cholesterol levels; the MD (95% CI) was −0.05 mmol/L (95% CI: −0.09 to −0.01, p = 0.02), −0.05 mmol/L (95% CI: −0.09 to −0.00, p = 0.03), and −0.1 mmol/mL (95% CI: −0.12 to −0.07 mmol/L, p 〈 0.00001), respectively. In the case of 230R 〉 C, the serum total cholesterol concentration of C carriers was significantly lower than that of RR carriers (−0.2 mmol/L, 95% CI: −0.3 to −0.11, p 〈 0.0001). Conclusion: This meta-analysis demonstrates that the ABCA1 69C 〉 T, 825V 〉 I, and 230R 〉 C polymorphisms could affect the plasma lipid concentration. As the plasma lipid concentration may be related to various diseases, ABCA1 genotyping could be useful for the management of lipid levels.
Materialart:
Online-Ressource
ISSN:
2075-4426
Sprache:
Englisch
Verlag:
MDPI AG
Publikationsdatum:
2021
ZDB Id:
2662248-8
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