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Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure

Wang, Heming ; Noordam, Raymond ; Cade, Brian E. ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Molecular Psychiatry Vol. 26, No. 11 ( 2021-11), p. 6293-6304

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In: Molecular Psychiatry, Springer Science and Business Media LLC, Vol. 26, No. 11 ( 2021-11), p. 6293-6304

Type of Medium: Online Resource

ISSN: 1359-4184 , 1476-5578

URL: Article

DOI: 10.1038/s41380-021-01087-0

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 1502531-7

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Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Bentley, Amy R. ; COGENT-Kidney Consortium ; Sung, Yun J. ; [et al.]

Springer Science and Business Media LLC ; 2019

In: Nature Genetics Vol. 51, No. 4 ( 2019-4), p. 636-648

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In: Nature Genetics, Springer Science and Business Media LLC, Vol. 51, No. 4 ( 2019-4), p. 636-648

Type of Medium: Online Resource

ISSN: 1061-4036 , 1546-1718

URL: Article

DOI: 10.1038/s41588-019-0378-y

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XA 10000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 1494946-5

SSG: 12

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Kilpeläinen, Tuomas O. ; Bentley, Amy R. ; Noordam, Raymond ; [et al.]

Springer Science and Business Media LLC ; 2019

In: Nature Communications Vol. 10, No. 1 ( 2019-01-22)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2019-01-22)

Abstract: Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1 , LHX1 , SNTA1 , and CNTNAP2 , that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1 , LHX1 , and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1 , LHX1 , and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-018-08008-w

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2019

detail.hit.zdb_id: 2553671-0

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Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

de Vries, Paul S ; Brown, Michael R ; Bentley, Amy R ; [et al.]

Oxford University Press (OUP) ; 2019

In: American Journal of Epidemiology Vol. 188, No. 6 ( 2019-06-01), p. 1033-1054

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In: American Journal of Epidemiology, Oxford University Press (OUP), Vol. 188, No. 6 ( 2019-06-01), p. 1033-1054

Type of Medium: Online Resource

ISSN: 0002-9262 , 1476-6256

URL: Article

DOI: 10.1093/aje/kwz005

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2019

detail.hit.zdb_id: 2030043-8

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Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Sun, Daokun ; Richard, Melissa A. ; Musani, Solomon K. ; [et al.]

Elsevier BV ; 2021

In: Human Genetics and Genomics Advances Vol. 2, No. 1 ( 2021-01), p. 100013-

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In: Human Genetics and Genomics Advances, Elsevier BV, Vol. 2, No. 1 ( 2021-01), p. 100013-

Type of Medium: Online Resource

ISSN: 2666-2477

URL: Article

DOI: 10.1016/j.xhgg.2020.100013

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 3058157-6

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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Feitosa, Mary F. ; Kraja, Aldi T. ; Chasman, Daniel I. ; [et al.]

Public Library of Science (PLoS) ; 2018

In: PLOS ONE Vol. 13, No. 6 ( 2018-6-18), p. e0198166-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 13, No. 6 ( 2018-6-18), p. e0198166-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0198166

DOI: 10.1371/journal.pone.0198166.g001

DOI: 10.1371/journal.pone.0198166.t001

DOI: 10.1371/journal.pone.0198166.t002

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DOI: 10.1371/journal.pone.0198166.s001

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DOI: 10.1371/journal.pone.0198166.s003

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DOI: 10.1371/journal.pone.0198166.s005

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DOI: 10.1371/journal.pone.0198166.s010

DOI: 10.1371/journal.pone.0198166.s011

DOI: 10.1371/journal.pone.0198166.s012

DOI: 10.1371/journal.pone.0198166.s013

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DOI: 10.1371/journal.pone.0198166.s034

DOI: 10.1371/journal.pone.0198166.s035

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2018

detail.hit.zdb_id: 2267670-3

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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Sung, Yun J. ; Winkler, Thomas W. ; de las Fuentes, Lisa ; [et al.]

Elsevier BV ; 2018

In: The American Journal of Human Genetics Vol. 102, No. 3 ( 2018-03), p. 375-400

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In: The American Journal of Human Genetics, Elsevier BV, Vol. 102, No. 3 ( 2018-03), p. 375-400

Type of Medium: Online Resource

ISSN: 0002-9297

URL: Article

DOI: 10.1016/j.ajhg.2018.01.015

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 1473813-2

SSG: 12

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A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Sung, Yun Ju ; de las Fuentes, Lisa ; Winkler, Thomas W ; [et al.]

Oxford University Press (OUP) ; 2019

In: Human Molecular Genetics Vol. 28, No. 15 ( 2019-08-01), p. 2615-2633

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In: Human Molecular Genetics, Oxford University Press (OUP), Vol. 28, No. 15 ( 2019-08-01), p. 2615-2633

Abstract: Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P 〈 5 × 10−8, false discovery rate 〈 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.

Type of Medium: Online Resource

ISSN: 0964-6906 , 1460-2083

URL: Article

DOI: 10.1093/hmg/ddz070

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2019

detail.hit.zdb_id: 1474816-2

SSG: 12

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