In:
Clinical Transplantation, Wiley, Vol. 29, No. 10 ( 2015-10), p. 911-919
Abstract:
This study updates assessment of post‐transplant outcomes in Ig AN patients in the modern era of immunosuppression. Using UNOS / OPTN data, patients ≥18 yr of age with first kidney transplant (1/1/1999 to 12/31/2008) were analyzed. Multivariable Cox regression models and propensity score‐based matching techniques were used to estimate hazard ratios ( HR s) for death‐censored allograft survival ( DCGS ) and patient survival in Ig AN compared to non‐Ig AN . Results of multivariable regression were stratified by donor type (living vs. deceased). A total of 107, 747 recipients were included (4589 with Ig AN and 103 158 with non‐Ig AN ). Adjusted HR for DCGS showed no significant difference between Ig AN and non‐Ig AN . Ig AN had higher patient survival compared to non‐Ig AN ( HR 0.54, 95% CI 0.47–0.62, p 〈 0.0001 for deceased donors; HR 0.42, 95% CI 0.33–0.54, p 〈 0.0001 for living donors). Propensity score‐matched analysis was similar, with no significant difference in DCGS between matched groups and higher patient survival in Ig AN patients compared to non‐Ig AN group ( HR 0.54, 95% CI 0.47, 0.63; p‐value 〈 0.0001). Ig AN patients with first kidney transplant have superior patient survival and similar graft survival compared to non‐Ig AN recipients. Results can be used in prognostication and informed decision‐making about kidney transplantation in patients with Ig AN .
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2015.29.issue-10
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2004801-4
detail.hit.zdb_id:
639001-8
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