In:
Open Forum Infectious Diseases, Oxford University Press (OUP), Vol. 9, No. Supplement_2 ( 2022-12-15)
Kurzfassung:
COVID-19 reinfection is generally defined as having 2 positive SARS-CoV-2 tests greater than 90 days apart. The clinical implications and impact of COVID-19 reinfection are not completely understood. We evaluated clinical and demographic characteristics of patients with COVID-19 reinfection. Methods All SARS-CoV-2 polymerase chain reaction (PCR) tests performed at Joint Base San Antonio (JBSA), from March 27, 2020 through January 19, 2022 were analyzed. COVID-19 reinfection was defined as having 2 positive PCR tests & gt;90 days apart. Available data for comorbidities, travel, COVID-19 vaccination status, SARS-CoV-2 genotype, symptoms, hospitalization, and treatments were compared for first and second infections. Results A total of 310,704 SARS-CoV-2 PCR tests performed of which 25,543 (8.2%) were positive at JBSA during the study period. Patients with COVID-19 reinfection (n=532; 4.2%) were identified and 266 (50%) charts reviewed. The mean age was 36.5 (±15) years and approximately half were males and active duty members (Table 1). The median time from first to second infection was 326 days (IQR 160-385). Patients were predominantly unvaccinated (91.4%) at initial infection, however unvaccinated status was less common (40.2%) at second infection (40.2%; P & lt; 0.0001). A significantly higher proportion of patients were symptomatic at first infection (88.3%) compared to second infection (51.5%; P & lt; 0.001). Pneumonia diagnosis was significantly higher (4.9% vs. 0.4%; P=0.0011) whereas hospitalization was similar (2.6% vs. 2.3%; P=0.0788) for first compared to second infection. Among hospitalized patients, critical illness was common for first infection (57.1%) but none of the patients were critically ill with their second infection. A third episode of infection was rarely observed (1.5%). Of 80 genotype samples available, 14 (30%) were paired samples. Among all paired samples different genotypes were responsible for reinfection (Table 2). Conclusion Patients with COVID-19 reinfections were less likely to be symptomatic, had lower severity of illness, and typically had a different SARS-CoV-2 genotype at second infection. Reinfection occurred despite COVID-19 vaccination in many patients, which highlights the need to develop novel strategies for vaccination. Disclosures All Authors: No reported disclosures.
Materialart:
Online-Ressource
ISSN:
2328-8957
DOI:
10.1093/ofid/ofac492.1505
Sprache:
Englisch
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2022
ZDB Id:
2757767-3
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