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  • Online Resource  (4)
  • Chen, Qin-fen  (4)
  • Medicine  (4)
  • XA 33000  (4)
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  • Online Resource  (4)
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  • Medicine  (4)
RVK
  • 1
    Online Resource
    Online Resource
    Acquired Multiple Coagulation Factor Inhibitors Associated Bleeding Disorder
    American Society of Hematology ; 2008
    In:  Blood Vol. 112, No. 11 ( 2008-11-16), p. 4511-4511
    Details
    In: Blood, American Society of Hematology, Vol. 112, No. 11 ( 2008-11-16), p. 4511-4511
    Abstract: Objective: To inquire into the clinical features of acquired multiple coagulation factors inhibitors associated bleeding disorder. Methods: A case of acquired multiple coagulation factors inhibitors in clinical manifestations, diagnosis, treatment and result was described and related literatures were reviewed. Results: A 74-year-old man developed sustained wound bleeding after implantation of heart pacemaker. Prothrombin time (PT), activated partial thromboplastin time (APTT) were prolonged significantly. But thrombin time (TT), fibrinogen (Fg), platelet count(PLT) and liver function were normal. 3P test was negative. Further tests revealed that the activities of factor 2, 5, 7,8,9,10,11,12 were all less than 10%, and the inhibitors of these factors could be detected, with the titers ranging from 8~64 Bu. So acquired multiple coagulation factor inhibitors was diagnosed. Transfusion with frozen plasma and cryoprecipitate was ineffective, whereas the combination therapy with glucocorticoid plus plasma exchange seemed to be successful. The patient was cured. Conclusion: Acquired multiple coagulation factors inhibitors is a rare bleeding disorder. In fact, this is the first case, as far as we are aware. It may develop serious bleeding. Immunosuppressive agents, such as corticosteroids, used for suppression of autoantibodies formation and plasma exchange, used for eradication of inhibitors may have beneficial effects.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V112.11.4511.4511
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2008
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    An Investigation Report of Frozen Plasma Evidence-Based Transfusion in a Tertiary Care Teaching Hospital
    American Society of Hematology ; 2008
    In:  Blood Vol. 112, No. 11 ( 2008-11-16), p. 4076-4076
    Details
    In: Blood, American Society of Hematology, Vol. 112, No. 11 ( 2008-11-16), p. 4076-4076
    Abstract: Objective: To estimate the appropriateness of frozen plasma (FP) transfusions in a tertiary-care teaching hospital. Methods: The medical records of all hospitalized patients transfused with FP between 1 April 2007 and 31 April 2008 were reviewed, analyzed retrospectively according to the Clinical Blood Transfusion Technical Specification from Ministry of Healthy. Results: In 5084 times 13627 units FP transfusions, departments of surgery used 77.7%, and departments of internal medicine used 22.3%. The medical records showed that the reasons of FP transfusion included supply coagulation factors, supply intraoperative blood loss, postoperative supporting therapy for enhancement of wound healing, volume expansion, plasma exchange, nutritional support and massive transfusion. Overall, the 68.5% of FP transfusions were assessed as inappropriate. The inappropriateness rate in departments of surgery was 71.7%, and that in departments of internal medicine was 22.6%. Conclusion: There is considerable inappropriate transfusion of FP in our hospital, for there has some important objective reasons. It is stated that the Technical Specification is not suitable to the condition of blood production supply and clinical practice. Clinicians should follow evidence-based transfusion guidelines for appropriate use of FP. So we suggest the Technical Specification should be renew periodly.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V112.11.4076.4076
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2008
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Clinical Analysis of 22 Patients with Primary Fibrinolysis
    American Society of Hematology ; 2008
    In:  Blood Vol. 112, No. 11 ( 2008-11-16), p. 4528-4528
    Details
    In: Blood, American Society of Hematology, Vol. 112, No. 11 ( 2008-11-16), p. 4528-4528
    Abstract: Objective: To analysis the clinical features and therapy of acquired primary fibrinolysis. Methods: The underlying diseases, clinical manifestations, laboratory findings, treatment and outcomes of 22 primary fibrinolysis were analyzed retrospectively. Results: 22 patients were enrolled, 13 were male, and 9 were female. The median age was 54.9(17–77) years. The underlying diseases were ulcer of gastric-carcinoma bleeding, colorectal polypectomy by endoscope, intracranial tumor to get worse quickly, metanephric duct galeted by holmium laser+DJ tube implantation, herniorrhaphy of abdominal incision, gaster carcinosectomy, colon carcinosectomy, cerebral trauma and operation of cranium. Patients have bleeding and hemorrhage from surgical incisions or venipuncture or catheter sites in 1 to 7 days after trauma or surgery, with a disproportionately low level of fibrinogen (Fg), high level of tissue type plasminogen activator activity (t-PA) and a relatively normal of thrombin time (PT), activated partial thromboplastin time (APTT), thrombin time(TT), normal or nearly normal of platelet count. Diagnosis of primary fibrinolysis was established clearly, the patients were treated with plasma, cryoprecipitate, fibrinogen and fibrinolytic inhibitor PAMBA. Prognosis was quite good, 18/22 patients were cured. Conclusion: Primary fibrinolysis may complicate various disorders, most of them are trauma, surgery, and malignancy. Bleeding and hemorrhage from surgical incisions or venipuncture or catheter sites is a predominant clinical feature. Low fibrinogen level with a normal or nearly normal platelet count is a predominant laboratory feature. We should differentiate primary fibrinolysis from the secondary fibrinolysis in DIC. Control of the primary disease, use fibrinolytic inhibitor, and replace depleted clotting factors with plasma, cryoprecipitate, fibrinogen, most of patients can be cured.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V112.11.4528.4528
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2008
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Comparing Efficacy of Apheresis and Whole-Blood Derived Platelets Transfusions in Acute Leukemia Patients Who Undergo Chemotherapy without Remission.
    American Society of Hematology ; 2009
    In:  Blood Vol. 114, No. 22 ( 2009-11-20), p. 4189-4189
    Details
    In: Blood, American Society of Hematology, Vol. 114, No. 22 ( 2009-11-20), p. 4189-4189
    Abstract: Abstract 4189 Objective To determine the efficacy between apheresis platelet concentrates(APCs) and platelets (PLTs) derived from whole blood(WBD) transfusion in acute leukemia patients receiving chemotherapy without remission. Methods All patients received same ABO group and leukocyte depletion PLTs. According to the platelet count before and after transfusion, we used percent platelet recovery(PPR) and corrected count increment(CCI) at 24 hours post-transfusion to analysis the outcomes. Results A total of 130 patients between the ages of 14 and 80 received 771 times PLTs transfusion. 85 patients were males, and 45 were females. There were 596 times APCs and 175 times WBD. In APCs, the platelet counts were 11.97±10.43×109/L and 24.68±18.63×109/L pre- and post-transfusion(P 〈 0.001). In WBD, the platelet counts were 11.06±7.58×109/L and 22.88±18.00×109/L pre- and post-transfusion(P 〈 0.001). But there was no significant difference in the platelet count between the two types of platelet produces transfusion. According to PPR, if PPR 〈 20% is considered platelet transfusion refractoriness(PTR), the incidence rates of PTR in APCs and WBD were 46.98% and 49.71%, respectively. According to CCI, if CCI 〈 4.5×109/L is considered PTR, the incidence rates of PTR were 42.95% and 46.86%, respectively. The incidence rate of PTR was no significant difference in PPR and CCI between the two PLTs products. Conclusion For the patients of acute leukemia without remission, the incidence rate of PTR was high, even if they received same ABO group and leukocyte depletion products. The efficacy was not significant difference between APCs and WBD transfusions. Disclosures: No relevant conflicts of interest to declare.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V114.22.4189.4189
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2009
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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