In:
International Journal of Cancer, Wiley, Vol. 136, No. 6 ( 2015-03-15)
Abstract:
What's new? The recent discovery of 47 susceptibility loci associated with all or estrogen receptor‐negative breast cancer provided new opportunities for genetic risk prediction but it remained unclear how exposure levels of environmental (non‐genetic) risk factors influenced the risk assessment. In this gene‐environment study, the international team examined interactions between the single nucleotide polymorphisms and 13 established environmental risk factors including parity, height and alcohol consumption. Notably, relative risks of breast cancer associated with the susceptibility loci were not strongly modified by environmental risk factors, a finding that, if confirmed, has important implications for the risk assessment in breast cancer.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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