In:
The EMBO Journal, EMBO, Vol. 41, No. 13 ( 2022-07-04)
Abstract:
image The transition from dividing progenitors to post‐mitotic motor neurons is known to be controlled by the activity of specific transcription factors. Here, the noncoding MN2 locus is identified as a bifunctional modulator of motor neuron differentiation by controlling multiple post‐transcriptional circuitries. The MN2 locus controls the transition of dividing progenitors to post‐mitotic motor neurons (MNs). MN2 function is mediated by expression of both short (miRNA) and long (lncRNA) non‐coding RNAs. The long noncoding RNA lncMN2‐203 promotes MN maturation as a sponge for miR‐466i‐5p and upregulating targets involved in MN differentiation and function. Co‐transcribed miRNAs miR‐325‐3p and miR‐384‐5p repress proliferation gene pathways through the control of cell cycle‐related factors.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2021108918
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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