In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 10 ( 2022-10-4), p. e0010815-
Abstract:
Campylobacter spp. are a major cause of bacterial diarrhea worldwide and are associated with high rates of mortality and linear growth faltering in children living in low- to middle-income countries (LMICs). Campylobacter jejuni and Campylobacter coli are most often the causative agents of enteric disease among children in LMICs. However, previous work on a collection of stool samples from children under 2 years of age, living in a low resource community in Peru with either acute diarrheal disease or asymptomatic, were found to be qPCR positive for Campylobacter species but qPCR negative for C . jejuni and C . coli . The goal of this study was to determine if whole-genome shotgun metagenomic sequencing (WSMS) could identify the Campylobacter species within these samples. The Campylobacter species identified in these stool samples included C . jejuni , C . coli , C . upsaliensis , C . concisus , and the potential new species of Campylobacter , " Candidatus Campylobacter infans ". Moreover, WSMS results demonstrate that over 65% of the samples represented co-infections with multiple Campylobacter species present in a single stool sample, a novel finding in human populations.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0010815
DOI:
10.1371/journal.pntd.0010815.g001
DOI:
10.1371/journal.pntd.0010815.g002
DOI:
10.1371/journal.pntd.0010815.g003
DOI:
10.1371/journal.pntd.0010815.t001
DOI:
10.1371/journal.pntd.0010815.t002
DOI:
10.1371/journal.pntd.0010815.s001
DOI:
10.1371/journal.pntd.0010815.s002
DOI:
10.1371/journal.pntd.0010815.s003
DOI:
10.1371/journal.pntd.0010815.s004
DOI:
10.1371/journal.pntd.0010815.s005
DOI:
10.1371/journal.pntd.0010815.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2429704-5
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