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  • SAGE Publications  (48)
  • 2015-2019  (48)
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  • SAGE Publications  (48)
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  • 2015-2019  (48)
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  • 1
    Online Resource
    Online Resource
    Expression and significance of molecular profiles on eosinophils of children with food allergy
    SAGE Publications ; 2019
    In:  European Journal of Inflammation Vol. 17 ( 2019-01), p. 205873921986860-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 17 ( 2019-01), p. 205873921986860-
    Abstract: Peripheral blood eosinophils may increase in food allergy (FA). However, the correlation between activation status of blood eosinophils and features of FA are unknown. We collected 25 cases of FA out-patients with increased number of eosinophils and 20 healthy children. Eosinophil surface markers were analyzed by flow cytometry. We found that CD23, CD44, CD54, and CRTH2 were positive on different eosinophils and that their expressions were increased in FA patients compared to the control individuals. There was a positive correlation with strong protein–protein interactions between the four eosinophil surface markers which were functionally involved in regulation of cell killing, interferon-gamma-mediated signaling pathway, and Epstein–Barr virus infection pathway. Thus, blood eosinophils change their phenotype during FA and induce significant gene regulation changes that may cause FA with eosinophilia. Detection of the expression of CD23, CD44, CD54, and CRTH2 on eosinophils can be used as indicators of FA with eosinophilia.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/2058739219868601
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2584683-8
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  • 2
    Online Resource
    Online Resource
    Effect of moxibustion on the expression of GDNF and its receptor GFRα3 in the colon and spinal cord of rats with irritable bowel syndrome
    SAGE Publications ; 2019
    In:  Acupuncture in Medicine Vol. 37, No. 4 ( 2019-08), p. 244-251
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 37, No. 4 ( 2019-08), p. 244-251
    Abstract: Moxibustion treatment has been found to ameliorate clinical symptoms including abdominal pain, diarrhoea and constipation in patients with irritable bowel syndrome (IBS). Herein we investigated the mechanisms underlying the use of moxibustion in a rat model of IBS. Methods: In our study, an IBS model was established in rats by colorectal distension (CRD) stimulus and mustard oil enema. The rats were randomly divided into a normal group, model group, mild moxibustion group, electroacupuncture group, probiotic group and dicetel group. Abdominal withdrawal reflex (AWR) scores were determined within 90 min of the last treatment. The expression of GDNF/GFRα3 protein and mRNA in the colon and spinal cord were detected by immunohistochemistry and quantitative real-time-PCR, respectively. Results: The IBS model rats had significantly higher AWR scores than the normal group ( P 〈 0.01). After mild moxibustion treatment, the AWR score was significantly reduced (20 mm Hg, P 〈 0.05; 40 mm Hg, 60 mm Hg and 80 mm Hg, P 〈 0.01). The model group showed significantly more colonic glial cell line-derived neurotrophic factor (GDNF/GFRα3 (GDNF family receptor α3) protein and mRNA expression in the colon and spinal cord than the normal group ( P 〈 0.01). Compared with the model group, the expression of GDNF/GFRα3 protein and mRNA in the colon and spinal cord of the rats were significantly decreased in the mild moxibustion group (colon: GDNF and GFRα3 protein, P 〈 0.01; GDNF and GFRα3 mRNA, P 〈 0.01; spinal cord: GDNF and GFRα3 protein, P 〈 0.01; GDNF mRNA, P 〈 0.05, GFRα3 mRNA, P 〈 0.01). Conclusions: Our data suggest that moxibustion therapy may mitigate CRD-induced increases in the expression of GDNF and its receptor GFRα3 in the colon and spinal cord in a rat model of IBS.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1136/acupmed-2017-011455
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2126127-1
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  • 3
    Online Resource
    Online Resource
    High-Pressure Measurements of Temperature and CO 2 Concentration Using Tunable Diode Lasers at 2 μm
    SAGE Publications ; 2016
    In:  Applied Spectroscopy Vol. 70, No. 3 ( 2016-03), p. 474-484
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 70, No. 3 ( 2016-03), p. 474-484
    Abstract: A sensor for simultaneous measurements of temperature and carbon dioxide (CO 2 ) concentration at elevated pressure is developed using tunable diode lasers at 2 µm. Based on some selection rules, a CO 2 line pair at 5006.140 and 5010.725 cm −1 is selected for the TDL sensor. In order to ensure the accuracy and rapidity of the sensor, a quasi-fixed-wavelength WMS is employed. Normalization of the 2 f signal with the 1 f signal magnitude is used to remove the need for calibration and correct for transmission variation due to beam steering, mechanical misalignments, soot, and windows fouling. Temperatures are obtained from comparison of the background-subtracted 1 f-normalized WMS-2 f signals ratio and a 1 f-normalized WMS-2 f peak values ratio model. CO 2 concentration is inferred from the 1 f-normalized WMS-2 f peak values of the CO 2 transition at 5006.140 cm −1 . Measurements of temperature and CO 2 concentration are carried out in static cell experiments ( P = 1–10 atm, T = 500–1200 K) to validate the accuracy and ability of the sensor. The results show that accuracy of the sensor for temperature and CO 2 concentration are 1.66% temperature and 3.1%, respectively. All the measurements show the potential utility of the sensor for combustion diagnose at elevated pressure.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1177/0003702815626672
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    An improved artificial potential field method of trajectory planning and obstacle avoidance for redundant manipulators
    SAGE Publications ; 2018
    In:  International Journal of Advanced Robotic Systems Vol. 15, No. 5 ( 2018-09-01), p. 172988141879956-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 15, No. 5 ( 2018-09-01), p. 172988141879956-
    Abstract: In this article, we present an improved artificial potential field method of trajectory planning and obstacle avoidance for redundant manipulators. Specifically, we not only focused on the position for the manipulator end-effectors but also considered their posture in the course of trajectory planning and obstacle avoidance. We introduced boundaries for Cartesian space components to optimize the attractive field function. Moreover, the manipulator achieved a reasonable speed to move to the target pose, regardless of the difference between the initial pose and target pose. We proved the stability using Lyapunov stability theory by introducing velocity feedforward, when the manipulator moved along a continuous trajectory. Considering the shape of the manipulator joints and obstacles, we set up the collision detection model by projecting the obstacles to link coordinates. In this case, establishing the repulsive field between the nearest points on every joint and obstacles with the closest distance was sufficient for achieving obstacle avoidance for redundant manipulators. The simulation results based on a nine-degree-of-freedom hyper-redundant manipulator, which was designed and made in our laboratory, fully substantiated the efficacy and superiority of the proposed method.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.1177/1729881418799562
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2202393-8
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  • 5
    Online Resource
    Online Resource
    Eliminating systematic bias from case-crossover designs
    SAGE Publications ; 2019
    In:  Statistical Methods in Medical Research Vol. 28, No. 10-11 ( 2019-11), p. 3100-3111
    Details
    In: Statistical Methods in Medical Research, SAGE Publications, Vol. 28, No. 10-11 ( 2019-11), p. 3100-3111
    Abstract: Case-crossover designs have been widely applied to epidemiological and medical investigations of associations between short-term exposures and risk of acute adverse health events. Much effort has been made in literature on understanding source of confounding and reducing systematic bias by reference-select strategies. In this paper, we explored the nature of bias in the ambi-directional and time-stratified case-crossover designs via simulation using actual air pollution data from urban Edmonton, Alberta, Canada. We further proposed a calibration approach for eliminating systematic bias in estimates (coefficient estimate, 95% confident interval, and p-value). Bias check for coefficient estimation, size check and power check for significance test were done via simulation experiments to show advantages of the calibrated case-crossover studies over the ones without calibration. An application was done to investigate associations between air pollutants and acute myocardial infarction hospitalizations in urban Edmonton. In conclusion, systematic bias in a case-crossover design is often unavoidable, leading to an obvious bias in the estimated effect and an unreliable p value in the significance test. The proposed calibration technique provides an efficient approach to eliminating systematic bias in a case-crossover study.
    Type of Medium: Online Resource
    ISSN: 0962-2802 , 1477-0334
    URL: Article
    DOI: 10.1177/0962280218797145
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2001539-2
    detail.hit.zdb_id: 1136948-6
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  • 6
    Online Resource
    Online Resource
    Dressing scheme and process parameters analysis for bonnet tool in bonnet polishing
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 231, No. 19 ( 2017-10), p. 3569-3578
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 231, No. 19 ( 2017-10), p. 3569-3578
    Abstract: Bonnet polishing is widely used in final processing of optical elements, as the bonnet tool has the characteristic of fine surface adaptability and controllable pressure. For the purpose of ensuring the stability and exact controllability of polishing process, it is necessary to make precise dressing of bonnet tool. In this paper, first a dressing scheme using cup diamond wheel is proposed for bonnet tool, and then the feasibility of the dressing scheme is verified by analyzing the trajectory and the envelope of the diamond particles on the cup wheel. After that, the influences of the dressing process parameters on the dressing efficiency and trajectory distribution are defined through theoretical analysis and MATLAB simulation, and by simulation the dressing process parameters are determined. In addition, a trimmed program with variable speed ratio is proposed to homogenize the dressing tracks. Finally, an experiment was conducted to test the simulation result. This paper provides the theoretical basis for actual dressing process of the bonnet tool.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406216647754
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2024890-8
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  • 7
    Online Resource
    Online Resource
    Two Novel Mutations in the C-Terminal Region of Centrosomal Protein 290 ( CEP290 ) Result in Classic Joubert Syndrome
    SAGE Publications ; 2015
    In:  Journal of Child Neurology Vol. 30, No. 6 ( 2015-05), p. 772-776
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 30, No. 6 ( 2015-05), p. 772-776
    Abstract: Joubert syndrome is a neurologic disorder with a pathognomonic “molar tooth sign” on brain imaging. The purpose of this study was to identify potential mutations in a Chinese patient with Joubert syndrome by targeted massively parallel sequencing. Taking advantage of high-throughput DNA sequencing technologies, 18 Joubert-causing genes of a Chinese patient with classic Joubert syndrome were sequenced at a time, and 2 novel variants in the CEP290 gene (c.7323_7327delAGAAG and c.6012-2A 〉 G) were identified in this patient. Sanger validation showed that 2 variants were inherited from each parents, respectively. Both variants are located in the C-terminal region of the CEP290 protein and are predicted to be deleterious. The results support that the combination of targeted genes enrichment and next-generation sequencing is valuable molecular diagnostic tool and suitable for clinical application.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073814535488
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2068710-2
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  • 8
    Online Resource
    Online Resource
    Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization
    SAGE Publications ; 2018
    In:  Technology in Cancer Research & Treatment Vol. 17 ( 2018-01), p. 153303381880998-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 17 ( 2018-01), p. 153303381880998-
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033818809984
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 9
    Online Resource
    Online Resource
    Characteristics and Triggering Conditions for Naturally Deposited Gravelly Soils that Liquefied following the 2008 Wenchuan M w 7.9 Earthquake, China
    SAGE Publications ; 2018
    In:  Earthquake Spectra Vol. 34, No. 3 ( 2018-08), p. 1091-1111
    Details
    In: Earthquake Spectra, SAGE Publications, Vol. 34, No. 3 ( 2018-08), p. 1091-1111
    Abstract: The 2008 M w 7.9 Wenchuan, earthquake caused naturally deposited ravelly soils to liquefy over a wide area. Although liquefaction of gravely soils is recognized by the geotechnical profession, observations of liquefaction and nonlique-faction case histories within the literature are few. Through several years of systematic study following the 2008 Wenchuan earthquake (M w 7.9), 92 locations of gravel liquefaction were identified, described, and mapped. These locations lie within an approximately 3,000 km 2 area of the Chengdu Plain. Peak ground accelerations estimated at the sites range from 0.15 g to 0.49 g. Taken collectively, these studies reveal the necessary conditions for liquefaction triggering in gravelly materials. Grain size analyses indicates that the ejecta was much finer than the gravels that liquefied. Gravel contents of liquefied soils ranged from 5% to more than 85%. The liquefied gravelly soils were loose, but their measured shear wave velocities range from 133 m/s to 267 m/s, with corrected values ranging from 154 m/s to 31 4m/s. The unique depositional conditions under Chengdu Plain provide favorable conditions for extensive liquefaction of gravelly soils. The shallow soil profiles consist of a 0.5 m to 5.5 m impermeable soil (i.e., the capping layer) overlying gravels ranging in thickness from a few meters to hundreds of meters.
    Type of Medium: Online Resource
    ISSN: 8755-2930 , 1944-8201
    URL: Article
    DOI: 10.1193/032017EQS050M
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2183411-8
    SSG: 16,13
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  • 10
    Online Resource
    Online Resource
    Netrin-1 promotes mesenchymal stem cell revascularization of limb ischaemia
    SAGE Publications ; 2016
    In:  Diabetes and Vascular Disease Research Vol. 13, No. 2 ( 2016-03), p. 145-156
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 13, No. 2 ( 2016-03), p. 145-156
    Abstract: This study examines the effect and mechanism of action of Netrin-1 on bone marrow mesenchymal stem cells in angiogenesis. Tube formation and migration of bone marrow mesenchymal stem cells were observed in cell culture. Bone marrow mesenchymal stem cells or Netrin-1–bone marrow mesenchymal stem cells were injected into the ischaemic area of the rat hind limb on the first day after surgery. Laser Doppler perfusion imaging was performed to analyse the levels of vascular endothelial growth factor in plasma and muscles, and immunohistochemistry and immunofluorescence were used to analyse angiogenesis. Bone marrow mesenchymal stem cells in medium containing Netrin-1 markedly increased the number of tubes formed and the migration of bone marrow mesenchymal stem cells compared with the untreated control group. The function of Netrin-1 in tube formation and migration is similar to vascular endothelial growth factor, and combined with vascular endothelial growth factor, Netrin-1 has more enhanced effect than in the other three groups. The Netrin-1–bone marrow mesenchymal stem cell group had better augmented blood-perfusion scores and vessel densities, as well as improved function of the ischaemic limb than that of the group injected with bone marrow mesenchymal stem cells (treated with bone marrow mesenchymal stem cells individually) or the control group (treated with medium). These results suggest that Netrin-1 has the ability to augment the angiogenesis of bone marrow mesenchymal stem cells and improve the function of the ischaemic hind limb by increasing the level of vascular endothelial growth factor.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/1479164115611594
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2250797-8
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