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  • SAGE Publications  (5)
  • 2015-2019  (5)
  • 2017  (5)
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  • SAGE Publications  (5)
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  • 2015-2019  (5)
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  • 2017  (5)
  • 1
    Online Resource
    Online Resource
    Dressing scheme and process parameters analysis for bonnet tool in bonnet polishing
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 231, No. 19 ( 2017-10), p. 3569-3578
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 231, No. 19 ( 2017-10), p. 3569-3578
    Abstract: Bonnet polishing is widely used in final processing of optical elements, as the bonnet tool has the characteristic of fine surface adaptability and controllable pressure. For the purpose of ensuring the stability and exact controllability of polishing process, it is necessary to make precise dressing of bonnet tool. In this paper, first a dressing scheme using cup diamond wheel is proposed for bonnet tool, and then the feasibility of the dressing scheme is verified by analyzing the trajectory and the envelope of the diamond particles on the cup wheel. After that, the influences of the dressing process parameters on the dressing efficiency and trajectory distribution are defined through theoretical analysis and MATLAB simulation, and by simulation the dressing process parameters are determined. In addition, a trimmed program with variable speed ratio is proposed to homogenize the dressing tracks. Finally, an experiment was conducted to test the simulation result. This paper provides the theoretical basis for actual dressing process of the bonnet tool.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406216647754
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2024890-8
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    Online Resource
  • 2
    Online Resource
    Online Resource
    A Highly Efficient Heterogeneous Ruthenium-Catalysed Oxidative α-Cyanation of Tertiary Amines Leading to α-Aminonitriles
    SAGE Publications ; 2017
    In:  Journal of Chemical Research Vol. 41, No. 10 ( 2017-10), p. 576-580
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 41, No. 10 ( 2017-10), p. 576-580
    Abstract: Oxidative α-cyanation of tertiary amines was achieved by using an MCM-41-immobilised N-alkylethylenediamine ruthenium(III) complex (MCM-41-2N-RuCl 3 ) as catalyst in MeOH at 60 °C in the presence of H 2 O 2 as oxidant and NaCN in acetic acid as a cyanide source to afford the corresponding α-aminonitriles in good yields. The new heterogeneous ruthenium catalyst can easily be prepared by a simple two-step procedure from commercially readily available and inexpensive reagents. It can be recovered by filtration of the reaction solution and reused at least 7 times without significant loss of activity.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751917X15064232103065
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 3010810-X
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  • 3
    Online Resource
    Online Resource
    Predictive Nomogram of RAGE Genetic Polymorphisms and Metabolic Risk Factors for Myocardial Infarction Risk in a Han Chinese Population
    SAGE Publications ; 2017
    In:  Angiology Vol. 68, No. 10 ( 2017-11), p. 877-883
    Details
    In: Angiology, SAGE Publications, Vol. 68, No. 10 ( 2017-11), p. 877-883
    Abstract: We investigated the association of 4 well-characterized polymorphisms in receptor for the advanced glycation end-product ( RAGE) gene with myocardial infarction (MI) risk and the changes in metabolic risk factors among 717/612 patients/controls, with the aim of constructing a predictive nomogram. The genotype/allele distributions differed significantly between the 2 groups for T-429C ( P genotype/allele = .004/.001) and G1704T ( P 〈 .001/.001). T-429C was significantly associated with MI risk, especially under a recessive model (adjusted odds ratio: 2.24, 95% confidence interval: 1.33-3.79, P = .003). For G1704T, significance was detected under additive (1.37; 1.12-1.67; P = .002) and recessive (3.86; 2.27-6.57; P 〈 .001) models. There were significant differences in blood pressure and low-density lipoprotein cholesterol (LDL-C) across T-429C genotypes and in total cholesterol and LDL-C across G1704T genotypes. The overall best multifactor dimensionality reduction model included dyslipidemia, G1704T, and T-429C. Further predictive nomogram on 2 significant polymorphisms, blood pressure and lipids, showed a better predictive capability (concordance index = 0.716, P 〈 .001). Altogether, we identified 2 polymorphisms of RAGE, T-429C and G1704T, which interacted with metabolic risk factors associated with the occurrence of MI. We also constructed a genetic–metabolic nomogram that can better predict MI risk.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319717696622
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2065911-8
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  • 4
    Online Resource
    Online Resource
    Effect of Electroacupuncture on the Expression of Agrin and Acetylcholine Receptor Subtypes in Rats with Tibialis Anterior Muscular Atrophy Induced by Sciatic Nerve Injection Injury
    SAGE Publications ; 2017
    In:  Acupuncture in Medicine Vol. 35, No. 4 ( 2017-08), p. 268-275
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 35, No. 4 ( 2017-08), p. 268-275
    Abstract: To investigate the effects of electroacupuncture (EA) on mRNA and protein expression of agrin, acetylcholine receptor (AChR)-ε and AChR-γ in a rat model of tibialis anterior muscle atrophy induced by sciatic nerve injection injury, and to examine the underlying mechanism of action. Methods Fifty-four adult Sprague-Dawley rats were divided into four groups: healthy control group (CON, n=6); sciatic nerve injury group (SNI, n=24), comprising rats euthanased at 1, 2, 4 and 6 weeks, respectively, after penicillin injection-induced SNI (n=6 each); CON+EA group (n=12), comprising healthy rats euthanased at 4 and 6 weeks (after 2 and 4 weeks, respectively, of EA at GB30 and ST36); and SNI+EA group, comprising rats euthanased at 4 and 6 weeks (after 2 and 4 weeks, respectively, of EA). The sciatic nerve functional index (SFI), tibialis anterior muscle weight, muscle fibre cross-sectional area (CSA), and changes in agrin, AChR-ε, and AChR-γ expression levels were analysed. Results Compared with the control group (CON), SNI rats showed decreased SFI. The weight of the tibialis anterior muscle and muscle fibre CSA decreased initially and recovered slightly over time. mRNA/protein expression of agrin and AChR-ε were downregulated and AChR-γ expression was detectable (vs zero expression in the CON/CON+EA groups). There were no significant differences in CON+EA versus CON groups. However, the SNI+EA group exhibited significant improvements compared with the untreated SNI group (p 〈 0.05). Conclusions EA may alleviate tibialis anterior muscle atrophy induced by sciatic nerve injection injury by upregulating agrin and AChR-ε and downregulating AChR-γ.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1136/acupmed-2015-011005
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2126127-1
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  • 5
    Online Resource
    Online Resource
    Identification of a Disease-Causing Mutation in a Chinese Patient with Retinitis Pigmentosa by Targeted Next-Generation Sequencing
    SAGE Publications ; 2017
    In:  European Journal of Ophthalmology Vol. 27, No. 6 ( 2017-11-08), p. 791-796
    Details
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 27, No. 6 ( 2017-11-08), p. 791-796
    Abstract: To identify disease-causing mutations in a Chinese patient with retinitis pigmentosa (RP). Methods A detailed clinical examination was performed on the proband. Targeted next-generation sequencing (NGS) combined with bioinformatics analysis was performed on the proband to detect candidate disease-causing mutations. Sanger sequencing was performed on all subjects to confirm the candidate mutations and assess cosegregation within the family. Results Clinical examinations of the proband showed typical characteristics of RP. Three candidate heterozygous mutations in 3 genes associated with RP were detected in the proband by targeted NGS. The 3 mutations were confirmed by Sanger sequencing and the deletion (c.357_358delAA) in PRPF31 was shown to cosegregate with RP phenotype in 7 affected family members, but not in 3 unaffected family members. Conclusions The deletion (c.357_358delAA) in PRPF31 was the disease-causing mutation for the proband and his affected family members with RP. To our knowledge, this is the second report of the deletion and the first report of the other 2 mutations in the Chinese population. Targeted NGS combined with bioinformatics analysis proved to be an effective molecular diagnostic tool for RP.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.5301/ejo.5000971
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 1475018-1
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