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  • 1
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    Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism [Articles] (2015)
    The American Society for Microbiology (ASM)
    Details
    Publikationsdatum: 2015-11-18
    Beschreibung: Cyclic AMP-responsive element-binding protein 3-like 3, hepatocyte specific (CREBH), is a hepatic transcription factor that functions as a key regulator of energy homeostasis. Here, we defined a regulatory CREBH posttranslational modification process, namely, lysine-specific acetylation, and its functional involvement in fasting-induced hepatic lipid metabolism. Fasting induces CREBH acetylation in mouse livers in a time-dependent manner, and this event is critical for CREBH transcriptional activity in regulating hepatic lipid homeostasis. The histone acetyltransferase PCAF-mediated acetylation and the deacetylase sirtuin-1-mediated deacetylation coexist to maintain CREBH acetylation states under fasting conditions. Site-directed mutagenesis and functional analyses revealed that the lysine (K) residue at position 294 (K294) within the bZIP domain of the CREBH protein is the site where fasting-induced acetylation/deacetylation occurs. Introduction of the acetylation-deficient (K294R) or acetylation-mimicking (K294Q) mutation inhibited or enhanced CREBH transcriptional activity, respectively. Importantly, CREBH acetylation at lysine 294 was required for the interaction and synergy between CREBH and peroxisome proliferator-activated receptor α (PPARα) in activating their target genes upon fasting or glucagon stimulation. Introduction of the CREBH lysine 294 mutation in the liver leads to hepatic steatosis and hyperlipidemia in animals under prolonged fasting. In summary, our study reveals a molecular mechanism by which fasting or glucagon stimulation modulates lipid homeostasis through acetylation of CREBH.
    Print ISSN: 0270-7306
    Digitale ISSN: 1098-5549
    Thema: Biologie , Medizin
    Publiziert von The American Society for Microbiology (ASM)
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Observation of Dirac cone band dispersions in FeSe thin films by photoemission spectroscopy (2016)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2016-03-10
    Beschreibung: Author(s): S. Y. Tan, Y. Fang, D. H. Xie, W. Feng, C. H. P. Wen, Q. Song, Q. Y. Chen, W. Zhang, Y. Zhang, L. Z. Luo, B. P. Xie, X. C. Lai, and D. L. Feng The search for novel materials with Dirac cone band dispersion is one of the most challenging and important works for both fundamental physics and technological applications. Here, we studied the electronic structure of FeSe thin films grown on SrTi O 3 substrates by angle-resolved photoemission spect… [Phys. Rev. B 93, 104513] Published Wed Mar 09, 2016
    Schlagwort(e): Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Pressure-induced phase transition in La_{1−x} Sm_{x} O_{0.5} F_{0.5} BiS_{2} (2015)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2015-09-16
    Beschreibung: Author(s): Y. Fang, D. Yazici, B. D. White, and M. B. Maple Electrical resistivity measurements on La 1 − x Sm x O 0.5 F 0.5 BiS 2 ( x = 0.1 , 0.3 , 0.6 , 0.8 ) have been performed under applied pressures up to 2.6 GPa from 2 K to room temperature. The superconducting transition temperature T c of each sample significantly increases at a Sm-concentration-dependent pressure P t , ind… [Phys. Rev. B 92, 094507] Published Tue Sep 15, 2015
    Schlagwort(e): Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Enhancement of superconductivity in La_{1−x}Sm_{x}O_{0.5}F_{0.5}BiS_{2} (2015)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2015-02-25
    Beschreibung: Author(s): Y. Fang, D. Yazici, B. D. White, and M. B. Maple The superconducting and normal-state properties of La 1−x Sm x O 0.5 F 0.5 BiS 2  (0.1≤x≤0.9) have been studied via electrical resistivity, magnetic susceptibility, and specific heat measurements. By using suitable synthesis conditions, Sm exhibits considerable solubility into the CeOBiS 2 -type LaO 0.5 F 0.5 BiS 2 ... [Phys. Rev. B 91, 064510] Published Tue Feb 24, 2015
    Schlagwort(e): Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Tunable Fe-vacancy disorder-order transition in FeSe thin films (2016)
    American Physical Society (APS)
    Details
    Publikationsdatum: 2016-05-11
    Beschreibung: Author(s): Y. Fang, D. H. Xie, W. Zhang, F. Chen, W. Feng, B. P. Xie, D. L. Feng, X. C. Lai, and S. Y. Tan Various Fe-vacancy orders have been reported in tetragonal β − F e 1 − x Se single crystals and nanowires/nanosheets, which are similar to those found in alkali-metal intercalated A 1 − x F e 2 − y S e 2 superconductors. Here we report the in situ angle-resolved photoemission spectroscopy study of Fe-vacancy disorder… [Phys. Rev. B 93, 184503] Published Tue May 10, 2016
    Schlagwort(e): Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Digitale ISSN: 1095-3795
    Thema: Physik
    Publiziert von American Physical Society (APS)
    Standort Signatur Einschränkungen Verfügbarkeit
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    PAPER CURRENT
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