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pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location (2013)

Zhonglei Lu; Genevieve Marcelin; Frederick Bauzon; Hongbo Wang; Hao Fu; Siok Le Dun; Hongling Zhao; Xiaosong Li; Young-Hwan Jo; Sharon Wardlaw; Nae Dun; Streamson Chua; Liang Zhu

Nature Publishing Group (NPG)

In: EMBO Journal

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Publication Date: 2013-03-21

Description: The EMBO Journal 32, 844 (2013). doi:10.1038/emboj.2013.25 Authors: Zhonglei Lu, Genevieve Marcelin, Frederick Bauzon, Hongbo Wang, Hao Fu, Siok Le Dun, Hongling Zhao, Xiaosong Li, Young-Hwan Jo, Sharon Wardlaw, Nae Dun, Streamson Chua & Liang Zhu pRb is frequently inactivated in tumours by mutations or phosphorylation. Here, we investigated whether pRb plays a role in obesity. The Arcuate nucleus (ARC) in hypothalamus contains antagonizing POMC and AGRP/NPY neurons for negative and positive energy balance, respectively. Various aspects of ARC neurons are

Keywords: E2F1high-fat dietobesityPOMC neuronspRb phosphorylation

Print ISSN: 0261-4189

Electronic ISSN: 1460-2075

Topics: Biology , Medicine

Published by Nature Publishing Group (NPG) on behalf of The European Molecular Biology Organization (EMBO).

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