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  • 1
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    SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology (2015)
    Nature Publishing Group (NPG)
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    Publication Date: 2015-01-29
    Description: Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a cell. Increasing evidence has also revealed that diverse genetic logic gates capable of generating a Boolean function play critically important roles in synthetic biology. Basic genetic logic gates have been designed to combine biological science with digital logic. SynBioLGDB (http://bioinformatics.ac.cn/synbiolgdb/) aims to provide the synthetic biology community with a useful resource for efficient browsing and visualization of genetic logic gates. The current version of SynBioLGDB documents more than 189 genetic logic gates with experimental evidence involving 80 AND gates and 16 NOR gates, etc. in three species (Human, Escherichia coli and Bacillus clausii). SynBioLGDB provides a user-friendly interface through which conveniently to query and browse detailed information about these genetic logic gates. SynBioLGDB will enable more comprehensive understanding of the connection of genetic logic gates to execute complex cellular functions in living cells. Scientific Reports 5 doi: 10.1038/srep08090
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 2
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    Reconfigurable radio-frequency arbitrary waveforms synthesized in a silicon photonic chip (2015)
    Nature Publishing Group (NPG)
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    Publication Date: 2015-01-14
    Description: Article Performing radio-frequency arbitrary waveform generation in the optical domain offers advantages over electronic-based methods but suffers from lack of integration and slow speed. Here, Wang et al . propose a fast-reconfigurable, radio-frequency arbitrary waveform generator fully integrated in a silicon chip. Nature Communications doi: 10.1038/ncomms6957 Authors: Jian Wang, Hao Shen, Li Fan, Rui Wu, Ben Niu, Leo T. Varghese, Yi Xuan, Daniel E. Leaird, Xi Wang, Fuwan Gan, Andrew M. Weiner, Minghao Qi
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer (2015)
    Nature Publishing Group (NPG)
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    Publication Date: 2015-02-17
    Description: Members of the inositol phosphate metabolism pathway regulate cell proliferation, migration and phosphatidylinositol-3-kinase (PI3K)/Akt signaling, and are frequently dysregulated in cancer. Whether germline genetic variants in inositol phosphate metabolism pathway are associated with cancer risk remains to be clarified. We examined the association between inositol phosphate metabolism pathway genes and risk of eight types of cancer using data from genome-wide association studies. Logistic regression models were applied to evaluate SNP-level associations. Gene- and pathway-based associations were tested using the permutation-based adaptive rank-truncated product method. The overall inositol phosphate metabolism pathway was significantly associated with risk of lung cancer (P = 2.00 × 10−4), esophageal squamous cell carcinoma (P = 5.70 × 10−3), gastric cancer (P = 3.03 × 10−2) and renal cell carcinoma (P = 1.26 × 10−2), but not with pancreatic cancer (P = 1.40 × 10−1), breast cancer (P = 3.03 × 10−1), prostate cancer (P = 4.51 × 10−1), and bladder cancer (P = 6.30 × 10−1). Our results provide a link between inherited variation in the overall inositol phosphate metabolism pathway and several individual genes and cancer. Further studies will be needed to validate these positive findings, and to explore its mechanisms. Scientific Reports 5 doi: 10.1038/srep08473
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 4
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    Film bulk acoustic resonators integrated on arbitrary substrates using a polymer support layer (2015)
    Nature Publishing Group (NPG)
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    Publication Date: 2015-04-01
    Description: The film bulk acoustic resonator (FBAR) is a widely-used MEMS device which can be used as a filter, or as a gravimetric sensor for biochemical or physical sensing. Current device architectures require the use of an acoustic mirror or a freestanding membrane and are fabricated as discrete components. A new architecture is demonstrated which permits fabrication and integration of FBARs on arbitrary substrates. Wave confinement is achieved by fabricating the resonator on a polyimide support layer. Results show when the polymer thickness is greater than a critical value, d, the FBARs have similar performance to devices using alternative architectures. For ZnO FBARs operating at 1.3–2.2 GHz, d is ~9 μm, and the devices have a Q-factor of 470, comparable to 493 for the membrane architecture devices. The polymer support makes the resonators insensitive to the underlying substrate. Yields over 95% have been achieved on roughened silicon, copper and glass. Scientific Reports 5 doi: 10.1038/srep09510
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 5
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    Anisotropic modulation of magnetic properties and the memory effect in a wide-band (011)-Pr0.7Sr0.3MnO3/PMN-PT heterostructure (2015)
    Nature Publishing Group (NPG)
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    Publication Date: 2015-04-25
    Description: Memory effect of electric-field control on magnetic behavior in magnetoelectric composite heterostructures has been a topic of interest for a long time. Although the piezostrain and its transfer across the interface of ferroelectric/ferromagnetic films are known to be important in realizing magnetoelectric coupling, the underlying mechanism for nonvolatile modulation of magnetic behaviors remains a challenge. Here, we report on the electric-field control of magnetic properties in wide-band (011)-Pr0.7Sr0.3MnO3/0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 heterostructures. By introducing an electric-field-induced in-plane anisotropic strain field during the cooling process from room temperature, we observe an in-plane anisotropic, nonvolatile modulation of magnetic properties in a wide-band Pr0.7Sr0.3MnO3 film at low temperatures. We attribute this anisotropic memory effect to the preferential seeding and growth of ferromagnetic (FM) domains under the anisotropic strain field. In addition, we find that the anisotropic, nonvolatile modulation of magnetic properties gradually diminishes as the temperature approaches FM transition, indicating that the nonvolatile memory effect is temperature dependent. By taking into account the competition between thermal energy and the potential barrier of the metastable magnetic state induced by the anisotropic strain field, this distinct memory effect is well explained, which provides a promising approach for designing novel electric-writing magnetic memories. Scientific Reports 5 doi: 10.1038/srep09668
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 6
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    The simple neuroendocrine-immune regulatory network in oyster 〈i〉Crassostrea gigas〈/i〉 mediates complex functions (2016)
    Nature Publishing Group (NPG)
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    Publication Date: 2016-05-20
    Description: The simple neuroendocrine-immune regulatory network in oyster 〈i〉Crassostrea gigas〈/i〉 mediates complex functions Scientific Reports, Published online: 19 May 2016; doi:10.1038/srep26396
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 7
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    Hollow Porous SiO2 Nanocubes Towards High-performance Anodes for Lithium-ion Batteries (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-03-29
    Description: The high theoretical capacity and low discharge potential of silicon have attracted much attention on Si-based anodes. Herein, hollow porous SiO2 nanocubes have been prepared via a two-step hard-template process and evaluated as electrode materials for lithium-ion batteries. The hollow porous SiO2 nanocubes exhibited a reversible capacity of 919 mAhg−1 over 30 cycles. The reasonable property could be attributed to the unique hollow nanostructure with large volume interior and numerous crevices in the shell, which could accommodate the volume change and alleviate the structural strain during Li ions' insertion and extraction, as well as allow rapid access of Li ions during charge/discharge cycling. It is found that the formation of irreversible or reversible lithium silicates in the anodes determines the capacity of a deep-cycle battery, fast transportation of Li ions in hollow porous SiO2 nanocubes is beneficial to the formation of Li2O and Si, contributing to the high reversible capacity. Scientific Reports 3 doi: 10.1038/srep01568
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 8
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    A strong and stretchable self-healing film with self-activated pressure sensitivity for potential artificial skin applications (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-11-06
    Description: Artificial skin, which mimics the functions of natural skin, will be very important in the future for robots used by humans in daily life. However, combining skin's pressure sensitivity and mechanical self-healing properties in a man-made material remains a challenging task. Here, we show that graphene and polymers can be integrated into a thin film which mimics both the mechanical self-healing and pressure sensitivity behavior of natural skin without any external power supply. Its ultimate strain and tensile strength are even two and ten times larger than the corresponding values of human skin, respectively. It also demonstrates highly stable sensitivity to a very light touch (0.02 kPa), even in bending or stretching states. Scientific Reports 3 doi: 10.1038/srep03138
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 9
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    Hierarchical Li4Ti5O12/TiO2 composite tubes with regular structural imperfection for lithium ion storage (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-12-13
    Description: Hierarchical Li4Ti5O12/TiO2 tubes composed of ultrathin nanoflakes have been successfully fabricated via the calcination of the hydrothermal product of a porous amorphous TiO2 precursor and lithium hydroxide monohydrate. The hierarchical tubes are characterized by powder X-ray diffraction, nitrogen adsorption/desorption, scanning electron microscopy and transmission electron microscopy techniques. These nanoflakes exhibit a quite complex submicroscopic structure with regular structural imperfection, including a huge number of grain boundaries and dislocations. The lithium ion storage property of these tubes is evaluated by galvanostatic discharge/charge experiment. The product shows initial discharge capacities of 420, 225, and 160 mAh g−1 at 0.01, 0.1, and 1.0 A g−1, respectively. After 100 cycles, the discharge capacity is 139 mAh g−1 at 1.0 A g−1 with a capacity retention of 87%, demonstrating good high-rate performance and good cycleability. The high electrochemical performance is attributed to unique structure and morphology of the tubes. The regular structural imperfection existed in the nanoflakes also benefit to lithium ion storage property of these tubes. The hierarchical Li4Ti5O12/TiO2 tubes are a promising anode material for lithium-ion batteries with high power and energy densities. Scientific Reports 3 doi: 10.1038/srep03490
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 10
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    Fe2O3 Nanoparticles Wrapped in Multi-walled Carbon Nanotubes With Enhanced Lithium Storage Capability (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-12-03
    Description: We have designed a novel hybrid nanostructure by coating Fe2O3 nanoparticles with multi-walled carbon nanotubes to enhance the lithium storage capability of Fe2O3. The strategy to prepare Fe2O3@MWCNTs involves the synthesis of Fe nanoparticles wrapped in MWCNTs, followed by the oxidation of Fe nanoparticles under carbon dioxide. When used as the anode in a Li-ion battery, this hybrid material (70.32 wt% carbon nanotubes, 29.68 wt% Fe2O3) showed a reversible discharge capacity of 515 mAhg−1 after 50 cycles at a density of 100 mAg−1 and the capacity based on Fe2O3 nanoparticles was calculated as 1147 mAhg−1, Three factors are responsibile for the superior performance: (1) The hollow interiors of MWCNTs provide enough spaces for the accommodation of large volume expansion of inner Fe2O3 nanoparticles, which can improving the stability of electrode; (2) The MWCNTs increase the overall conductivity of the anode; (3) A stable solid electrolyte interface film formed on the surface of MWCNTs may reduce capacity fading. Scientific Reports 3 doi: 10.1038/srep03392
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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