GLORIA — GEOMAR Library Ocean Research Information Access

Treffer pro Seite

Treffer 1 - 3 | 3 Treffer

Sortierung

Unbekannt

A method to rapidly create protein aggregates in living cells (2016)

Yusuke Miyazaki; Kota Mizumoto; Gautam Dey; Takamasa Kudo; John Perrino; Ling-chun Chen; Tobias Meyer; Thomas J. Wandless

Nature Publishing Group (NPG)

In: Nature Communications

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2016-05-29

Beschreibung: Article Protein aggregates are associated with a wide variety of diseases. Here, in order to address how protein aggregation affects cellular homoeostasis, the authors describe a method to rapidly create protein aggregates in living cells and organisms with precise spatial and temporal control. Nature Communications doi: 10.1038/ncomms11689 Authors: Yusuke Miyazaki, Kota Mizumoto, Gautam Dey, Takamasa Kudo, John Perrino, Ling-chun Chen, Tobias Meyer, Thomas J. Wandless

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Nature Publishing Group (NPG)

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

PAPER CURRENT

Volltext

Unbekannt

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model (2013)

Nina Cabezas-Wallscheid, Victoria Eichwald, Jos de Graaf, Martin Löwer, Hans-Anton Lehr, Andreas Kreft, Leonid Eshkind, Andreas Hildebrandt, Yasmin Abassi, Rosario Heck, Anna Katharina Dehof, Svetlana Ohngemach, Rolf Sprengel, Simone Wörtge, Steffen Schmitt, Johannes Lotz, Claudius Meyer, Thomas Kindler, Dong-Er Zhang, Bernd Kaina, John C. Castle, Andreas Trumpp, Ugur Sahin, Ernesto Bockamp

Wiley-Blackwell

In: EMBO Molecular Medicine

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2013-10-05

Beschreibung: The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progression was characterized by two principal pathogenic mechanisms. Initially, AE expression modified the lineage potential of haematopoietic stem cells (HSCs), resulting in the selective expansion of the myeloid compartment at the expense of normal erythro- and lymphopoiesis. This lineage skewing was followed by a second substantial rewiring of transcriptional networks occurring in the trajectory to manifest leukaemia. We also find that both HSC and lineage-restricted granulocyte macrophage progenitors (GMPs) acquired leukaemic stem cell (LSC) potential being capable of initiating and maintaining the disease. Finally, our data demonstrate that long-term expression of AE induces an indolent myeloproliferative disease (MPD)-like myeloid leukaemia phenotype with complete penetrance and that acute inactivation of AE function is a potential novel therapeutic option. This novel model system of AML1-ETO driven acute myeloid leukaemia addresses the concept of ‘oncogene addiction’. Better understanding of AML1-ETO need to maintain leukemia and rewire the transcriptome may help to design future therapies.

Print ISSN: 1757-4676

Digitale ISSN: 1757-4684

Thema: Medizin

Publiziert von Wiley-Blackwell im Namen von The European Molecular Biology Organization (EMBO).

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

PAPER CURRENT

Volltext

Unbekannt

Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors (2018)

Adam J. Meyer; Thomas H. Segall-Shapiro; Emerson Glassey; Jing Zhang; Christopher A. Voigt

Nature Publishing Group (NPG)

In: Nature Chemical Biology

zur Merkliste hinzufügen auf der Merkliste

Details

Publikationsdatum: 2018-11-27

Beschreibung: Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors 〈i〉Escherichia〈/i〉 coli “Marionette” strains with 12 highly optimized small-molecule sensors, Published online: 26 November 2018; doi:10.1038/s41589-018-0168-3 A directed evolution approach was applied to optimize a set of 12 small-molecule-responsive biosensors, which led to the engineering of “Marionette” strains of Escherichia coli incorporating these sensors for biotechnological applications.

Print ISSN: 1552-4450

Digitale ISSN: 1552-4469

Thema: Biologie , Chemie und Pharmazie

Publiziert von Nature Publishing Group (NPG)

Permalink

	Standort	Signatur	Einschränkungen	Verfügbarkeit

Andere fanden auch interessant ...

PAPER CURRENT

Volltext

Treffer 1 - 3 | 3 Treffer