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Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5 [Genetics] (2017)

Duanwu Zhang, Wataru Tomisato, Lijing Su, Lei Sun, Jin Huk Choi, Zhao Zhang, Kuan-wen Wang, Xiaoming Zhan, Mihwa Choi, Xiaohong Li, Miao Tang, Jose M. Castro-Perez, Sara Hildebrand, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2017-06-28

Description: The recessive N-ethyl-N-nitrosourea–induced phenotype toku is characterized by delayed hair growth, progressive hair loss, and excessive accumulation of dermal cholesterol, triglycerides, and ceramides. The toku phenotype was attributed to a null allele of Gk5, encoding glycerol kinase 5 (GK5), a skin-specific kinase expressed predominantly in sebaceous glands. GK5 formed a...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Tuning the Structures of AsMo12 and AsW12 into Chiral Crystals by Introducing CH3CN and H2O (2015)

Youlin Wang, Xiaoming Lu, Tao Min, Jun Feng

Wiley-Blackwell

In: Zeitschrift für Anorganische und Allgemeine Chemie

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Publication Date: 2015-01-28

Description: Abstract. The asymmetrical crystal [Na(15C5) 2 ][Na(15C5)] 2 (AsMo 12 O 40 )] · CH 3 CN ( 1 ) was synthesized. Interestingly, the huge α-keggin ion AsMo 12 is distorted by introduction of CH 3 CN molecules and adopts a chiral assembly with space group P 4 . In contrast, the analogous compound AsW 12 co-crystallizes with trace H 2 O molecules. The hydrogen atoms of H 2 O are positionally disordered with 50 % occupation to correlate with AsW 12 in space group P 4/ m . Solid and solution CD spectra indicate that the crystals of 1 are in R configuration. This leads to the conclusion that molybdenum has greater affinity toward organic CH 3 CN, whereas tungsten has greater affinity to inorganic H 2 O. Additionally, AsMo 12 shows greater deformability than AsW 12 . It is suggested that POMo shows a greater potential as chiral material than POW because of the flexibility of Mo. As a highlight, CH 3 CN can function as a general chiral inducer for the innovation of other chiral crystals, if fixed along one dimension.

Print ISSN: 0044-2313

Electronic ISSN: 1521-3749

Topics: Chemistry and Pharmacology

Published by Wiley-Blackwell

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Adȷuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice [Immunology and Inflammation] (2018)

Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Yuto Mifune, Hexin Shi, Kuan-wen Wang, Xiaoming Zhan, Aijie Liu, Jianhui Wang, Xiaohong Li, Miao Tang, Sara Ludwig, Sara Hildebrand, Kejin Zhou, Daniel J. Siegwart, Eva Marie Y. Moresco, Hong Zhang, Dale L. Boger, Bruce Beutler

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2018-09-12

Description: Successful cancer immunotherapy entails activation of innate immune receptors to promote dendritic cell (DC) maturation, antigen presentation, up-regulation of costimulatory molecules, and cytokine secretion, leading to activation of tumor antigen-specific cytotoxic T lymphocytes (CTLs). Here we screened a synthetic library of 100,000 compounds for innate immune activators using TNF production...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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