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Porin self-association enables cell-to-cell contact in Providencia stuartii floating communities [Biophysics and Computational Biology] (2018)

Mariam El–Khatib, Chady Nasrallah, Julie Lopes, Que–Tien Tran, Guillaume Tetreau, Hind Basbous, Daphna Fenel, Benoit Gallet, Mathilde Lethier, Jean–Michel Bolla, Jean–Marie Pages, Michel Vivaudou, Martin Weik, Mathias Winterhalter, Jacques–Philippe Colletier

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2018-03-07

Beschreibung: The gram-negative pathogen Providencia stuartii forms floating communities within which adjacent cells are in apparent contact, before depositing as canonical surface-attached biofilms. Because porins are the most abundant proteins in the outer membrane of gram-negative bacteria, we hypothesized that they could be involved in cell-to-cell contact and undertook a structure-function...

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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FtsK distinguishes dif sites [Microbiology] (2016)

Fournes, F., Crozat, E., Pages, C., Tardin, C., Salome, L., Cornet, F., Rousseau, P.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2016-07-13

Beschreibung: In bacteria, the FtsK/Xer/dif (chromosome dimer resolution site) system is essential for faithful vertical genetic transmission, ensuring the resolution of chromosome dimers during their segregation to daughter cells. This system is also targeted by mobile genetic elements that integrate into chromosomal dif sites. A central question is thus how Xer/dif...

Print ISSN: 0027-8424

Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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Noncanonical functions of C/D box snoRNAs [Biochemistry] (2016)

Falaleeva, M., Pages, A., Matuszek, Z., Hidmi, S., Agranat-Tamir, L., Korotkov, K., Nevo, Y., Eyras, E., Sperling, R., Stamm, S.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2016-03-24

Beschreibung: C/D box small nucleolar RNAs (SNORDs) are small noncoding RNAs, and their best-understood function is to target the methyltransferase fibrillarin to rRNA (for example, SNORD27 performs 2′-O-methylation of A27 in 18S rRNA). Unexpectedly, we found a subset of SNORDs, including SNORD27, in soluble nuclear extract made under native conditions, where...

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Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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The immune contexture in human tumours: impact on clinical outcome (2012)

Wolf Herman Fridman; Franck Pagès; Catherine Sautès-Fridman; Jérôme Galon

Nature Publishing Group (NPG)

In: Nature Reviews Cancer

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Publikationsdatum: 2012-03-23

Beschreibung: The immune contexture in human tumours: impact on clinical outcome Nature Reviews Cancer 12, 298 (2012). doi:10.1038/nrc3245 Authors: Wolf Herman Fridman, Franck Pagès, Catherine Sautès-Fridman & Jérôme Galon Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss

Print ISSN: 1474-175X

Digitale ISSN: 1474-1768

Thema: Medizin

Publiziert von Nature Publishing Group (NPG)

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Chronology in lesion tolerance [Biochemistry] (2014)

Naiman, K., Philippin, G., Fuchs, R. P., Pages, V.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publikationsdatum: 2014-04-16

Beschreibung: The encounter of a replication fork with a blocking DNA lesion is a common event that cells need to address properly to preserve genome integrity. Cells possess two main strategies to tolerate unrepaired lesions: potentially mutagenic translesion synthesis (TLS) and nonmutagenic damage avoidance (DA). Little is known about the partitioning...

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Digitale ISSN: 1091-6490

Thema: Biologie , Medizin , Allgemeine Naturwissenschaft

Publiziert von National Academy of Sciences

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