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    TLR Interacts with CREBH to Modulate HDL [Molecular Bases of Disease] (2016)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2016-10-29
    Description: Bacterial endotoxin can induce inflammatory and metabolic changes in the host. In this study, we revealed a molecular mechanism by which a stress-inducible, liver-enriched transcription factor, cAMP-responsive element-binding protein hepatic-specific (CREBH), modulates lipid profiles to protect the liver from injuries upon the bacterial endotoxin lipopolysaccharide (LPS). LPS challenge can activate CREBH in mouse liver tissues in a toll-like receptor (TLR)/MyD88-dependent manner. Upon LPS challenge, CREBH interacts with TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase that functions as a key mediator of TLR signaling, and this interaction relies on MyD88. Further analysis demonstrated that TRAF6 mediates K63-linked ubiquitination of CREBH to facilitate CREBH cleavage and activation. CREBH directly activates expression of the gene encoding Apolipoprotein A4 (ApoA4) under LPS challenge, leading to modulation of high-density lipoprotein (HDL) in animals. CREBH deficiency led to reduced production of circulating HDL and increased liver damage upon high-dose LPS challenge. Therefore, TLR/MyD88-dependent, TRAF6-facilitated CREBH activation represents a mammalian hepatic defense response to bacterial endotoxin by modulating HDL.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 2
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    Study on detection method of distorted voltage sag in distribution network under the background of incorporating new energy (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-11-10
    Description: An advanced voltage sag detection method and compensation technique can improve the power quality of the distribution network to a entirely new level. A high performance voltage sag detection method demands fast response and good accuracy, even detecting distorted grid voltage sag caused by new energy accessing to distribution network. The voltage sag detection method, based on sliding window iterative discrete fourier transfer (DFT) algorithm, has excellent filtering ability but long detection time. On the other hand, the voltage sag detection method, based on nonrecursive DFT algorithm, has short detection time but poor filtering ability. Aiming to meet the requirements of fast response and good accuracy, this paper proposed a voltage sag detection method based on improved nonrecursive DFT algorithm. By means of disturbance filter, which is combined with several notch filters and a low-pass filter, the filter characteristic of nonrecursive DFT algorithm has been improved, and ...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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