In:
Tijdschrift voor Urologie, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-01), p. 2-10
Abstract:
We created a model predicting the probability to detect prostate cancer recurrence outside the prostatic fossa in men with biochemical recurrence (BCR) after radical prostatectomy (RP). 419 patients with BCR (prostate specific antigen [PSA] 〈 2.0 ng/ml) after RP without hormone therapy underwent a 68 Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography/Computer Tomograpy (PET/CT)-scan. Predictors for the detection of prostate cancer recurrence outside the prostatic fossa were identified using multivariable logistic regression analysis. At a median PSA of 0,40 ng/ml (interquartile range 0,30–0,70), PSMA PET/CT detected prostate cancer recurrence outside the prostatic fossa in 174 (42%) patients. Significant predictors for the detection of prostate cancer recurrence outside the prostatic fossa were PSA value at time of scanning and RP specimen characteristics Gleason-score, lymph node status and surgical margin status. PSA value at time of scanning and RP specimen characteristics, Gleason-score, lymph node status and surgical margin status are all important predictors for the probability to detect prostate cancer recurrence outside the prostatic fossa. The dashboard ( https://psma.prostatecancer-riskcalculator.com/ ) can be used to determine the clinical most optimal moment to perform a PSMA PET/CT scan.
Type of Medium:
Online Resource
ISSN:
2211-3037
,
2211-4718
DOI:
10.1007/s13629-020-00303-w
Language:
Dutch
Publisher:
Springer Science and Business Media LLC
Publication Date:
2021
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