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  • 1
    Online Resource
    Online Resource
    Diabeteses kisér-károsodás vizsgálata optikai koherencia tomográfián alapuló angiográfiával
    Akademiai Kiado Zrt. ; 2018
    In:  Orvosi Hetilap Vol. 159, No. 8 ( 2018-02), p. 320-326
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 159, No. 8 ( 2018-02), p. 320-326
    Abstract: Abstract: Introduction: Optical coherence tomography angiography is a non-invasive imaging technique that is able to visualize the different retinal vascular layers using motion contrast to detect blood flow without intravenous dye injection. This method might help to assess microangiopathy in diabetic retinopathy during screening and follow-up. Aim: To quantify retinal microvasculature alterations in both eyes of diabetic patients in relation to systemic risk factors using optical coherence tomography angiography. Method: Both eyes of 36 diabetic patients and 45 individuals without diabetes were examined. Duration of diabetes, insulin therapy, blood pressure, HbA 1c , dyslipidemia, axial length and the presence of diabetic retinopathy were recorded. Retinal vessel density was measured by optical coherence tomography angiography. The effect of risk factors on vessel density and between-eye asymmetry was assessed using multivariable regression analysis. Results: Vessel density was significantly lower and between-eye difference was significantly higher in diabetic patients compared to controls (p 〈 0.05). Both vessel density and between-eye asymmetry significantly correlated with diabetes duration (p 〈 0.05) after controlling for the effect of risk factors. The between-eye asymmetry in vessel density was significantly higher in patients without clinically detectable diabetic retinopathy compared to control subjects (p 〈 0.001). Conclusions: There is a decrease in retinal vessel density and an increase in between-eye asymmetry in patients with diabetes compared to healthy subjects. By using optical coherence tomography angiography, the detection of these microvascular alterations is possible before clinically detectable diabetic retinopathy and might serve as a useful tool in both screening and timing of treatment. Orv Hetil. 2018; 159(8): 320–326.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2018.30962
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2018
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  • 2
    Online Resource
    Online Resource
    Asztmás gyermekek egészségmagatartásának vizsgálata a média- és internethasználat és az önértékelés dimenziói mentén
    Akademiai Kiado Zrt. ; 2018
    In:  Orvosi Hetilap Vol. 159, No. 47 ( 2018-11), p. 1971-1980
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 159, No. 47 ( 2018-11), p. 1971-1980
    Abstract: Abstract: Introduction: According to the literature, somatic and psychological factors are connected with asthma bronchiale. The health behavior of these patients can be influenced by the virtual world. Aim: We wish to analyze social media and internet usage, self-esteem and sociodemographic data connected to attachment. Method: For our research, the Facebook Intensity Scale, the Problematic Internet Usage Questionnaire, the Rosenberg Self-Esteem Scale and a socio-demographic questionnaire were used. We interviewed 175 asthmatic children from the age of 10 to 18 (92 boys, 83 girls). Results: Asthmatic girls, children who went to daycare (under the age of 3) and who were not breastfed use Facebook more than boys, children who stayed at home instead of daycare and who were breastfed (p 〈 0.01). There is no difference in their internet usage. Breastfeeding (even if it only lasted for 1–7 days) can strengthen attachment which is shown in our results regarding social media usage compared with children who were not breastfed (p 〈 0.01). A negative relation with medium strength was found between the number of siblings (ρ = –0.400; p 〈 0.01) and the self-esteem and Facebook usage (ρ = –0.475; p 〈 0.01). There is a positive correlation between Facebook usage and the size of the place the children live in (ρ = 0.492; p 〈 0.01). Conclusions: Asthmatic youth use social media more frequently which provides social feedback to compensate their self-esteem, especially by girls. As protection factors, we can emphasize the existence of human relationships and the importance of an early mother-child bond. Orv Hetil. 2018; 159(47): 1971–1980.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2018.31203
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2018
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  • 3
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    Online Resource
    Az „emberfölötti ember” dilemmája Móricznál
    University of Szeged ; 2021
    In:  Iskolakultúra Vol. 31, No. 4 ( 2021-04-01), p. 39-50
    Details
    In: Iskolakultúra, University of Szeged, Vol. 31, No. 4 ( 2021-04-01), p. 39-50
    Abstract: Móriczra általában nem szokás úgy gondolni, mint a világirodalmi hatások bűvkörében alkotó íróra (talán az Isten háta mögött Flaubert-utalása kivételével). Pedig épp a Sárarany esetében mind a Bűn és bűnhődés, mind pedig a Zarathustra hatása egyértelműen kimutatható a motívumoktól kezdve egyes részletek megformálásán át a szereplők alakjának megalkotásáig. Mi több, a két mű alapkérdése: a közönséges és az „emberfeletti” ember ellentéte, a morál határainak kérdése, maga a bűn problematikája párbeszédbe állítja a két mű gondolatrendszerét a sajátosan magyar történet keretein belül. A tanulmány ennek a párbeszédnek a rekonstruálására, a Dosztojevszkij- és a Nietzsche-hatás tisztázására tesz kísérletet.
    Type of Medium: Online Resource
    ISSN: 1588-0818 , 1215-5233
    URL: Article
    DOI: 10.14232/10.14232/ISKKULT.2021.04.39
    Language: Hungarian
    Publisher: University of Szeged
    Publication Date: 2021
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  • 4
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    Online Resource
    Predictors of efficacy, mucosal healing and dose intensification during the first year of adalimumab therapy in patients with luminal and fistulizing Crohn’s disease. National data from Hungary
    Akademiai Kiado Zrt. ; 2011
    In:  Orvosi Hetilap Vol. 152, No. 36 ( 2011-09), p. 1433-1442
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 152, No. 36 ( 2011-09), p. 1433-1442
    Abstract: Adalimumab is a fully human monoclonal antibody targeting tumor necrosis factor with proven efficacy in the treatment of Crohn’s disease in clinical trials. The aim of the present study was to investigate the predictors of medium term clinical efficacy and mucosal healing during adalimumab therapy in patients with Crohn’s disease in specialized centers approved for biological therapy in Hungary. Methods: Data of 201 Crohn’s disease patients were prospectively captured (male/female: 112/89, median age: 24 years, duration: 8 years). Previous infliximab therapy was given in 97 (48.3%) patients, concomitant steroids in 41.3% and azathioprine in 69.2% (combined: 26.4%) of patients. Results: Overall clinical response and remission rates at 24 and 52 weeks were 78% and 52%, and 69.4% and 44.4%, respectively. Endoscopic improvement and healing was achieved in 43.1% and 23.6%, respectively. In a logistic regression model, clinical efficacy and normalized C-reactive protein at week 12, need for combined immunosuppression at induction, shorter disease duration and smoking were identified as independent predictors for 12-month clinical outcome, while normalized C-reactive protein at week 12, clinical remission at week 24, frequency of previous relapses and smoking were associated to endoscopic improvement/healing. Dose intensification to weekly dosing was needed in 16.4%. Parallel azathioprine therapy and clinical remission at week 12 was inversely associated to dose escalation to weekly dosing. Conclusion: Clinical efficacy and normalized C-reactive protein at week 12, need for combined immunosuppression, luminal disease and smoking are predictors for medium term clinical efficacy/mucosal healing during adalimumab therapy, while parallel azathioprine therapy may decrease the probability for dose escalation. Orv. Hetil., 2011, 152, 1433–1442.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/OH.2011.29200
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2011
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  • 5
    Online Resource
    Online Resource
    Long term intravitreal ranibizumab treatment for exsudative age-related macular degeneration
    Akademiai Kiado Zrt. ; 2013
    In:  Orvosi Hetilap Vol. 154, No. 45 ( 2013-11), p. 1790-1797
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 154, No. 45 ( 2013-11), p. 1790-1797
    Abstract: Introduction: The results of intravitreal ranibizumab treatment for exsudative age-related macular degeneration have been favourable until this time. Aim: To evaluate the two-year functional and anatomic results of intravitreal ranibizumab treatment. Method: 46 patients (age: 75±9.1 years) were included in a prospective single center study. Treatment regimen was the following: monthly 0.5 mg ranibizumab was administered in the first 3 months, and later as required (pro re nata). The change of best corrected visual acuity and central retinal thickness was followed. Results: The visus change at the end of the follow-up time was not statistically significant compared to baseline (p = 0.760) and the at the end of the first year (p = 0.154). Central retinal thickness decreased significantly compared to baseline (p = 0.000001), but the change was not statistically significant compared to the end of the first year (p = 0.875). Conclusions: Patients with neovascular macular degeneration treated with intravitreal ranibizumab using pro re nata regimen have stable visus for long term, and the exsudation could be reduced efficiently. Orv. Hetil., 154(45), 1790–1797.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/OH.2013.29729
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2013
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  • 6
    Online Resource
    Online Resource
    Outcome of a one-year behavior therapy weight loss program
    Akademiai Kiado Zrt. ; 2014
    In:  Orvosi Hetilap Vol. 155, No. 30 ( 2014-07), p. 1196-1202
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 155, No. 30 ( 2014-07), p. 1196-1202
    Abstract: Introduction: Treatment of obesity has become one of the most challenging issues. Aim: The aims of the authors were to present the results of standard behavior therapy weight loss program combined with self-help and the results of one-year follow-up. Method: The 24-week program involved 41 participants of which 33 subjects participated in the follow-up. Anthropometric data were obtained and the participants were asked to fill questionnaires (the 21 items Three Factor Eating Questionnair Revised 21 items; Physical Exercise: Steps of change [Short Form]. Results: 87.8% of participants achieved a minimum weight loss of 5% which is the rate expected in professional therapies for obesity. Significant changes in maladaptive eating pattern and an increase in the rate of regular exercise were observed. Significant association was found between the increase of cognitive restraint and the rate of weight loss during treatment. At one-year follow-up the majority of participants (75.8%) did keep their minimum weight loss of 5% and they showed significant change in eating pattern. Conclusions: The results suggest that standard behavior therapy extended with self-help elements may be a cost-effective treatment of obesity. Orv. Hetil., 2014, 155(30), 1196–1202.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/OH.2014.29948
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2014
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  • 7
    Online Resource
    Online Resource
    Aphakia korrekciója irisklip műlencse retropupillaris beültetésével
    Akademiai Kiado Zrt. ; 2017
    In:  Orvosi Hetilap Vol. 158, No. 1 ( 2017-01), p. 20-24
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 158, No. 1 ( 2017-01), p. 20-24
    Abstract: Abstract: Introduction and aim: The correction of aphakia might be a challenge for the surgeon. The aim of this study is to describe the authors’ experience with the implantation of the retropupillary iris clip intraocular lens. Method: Patients between January 2014 and December 2015 were included in the retrospective study. Retropupillary implantation of iris clip intraocular lens VRSA 54 (AMO Advanced Medical Optics, USA) was performed in all cases. The minimum follow up period was three months. The stability of the intraocular lens and the intraoperative and postoperative complications and the visual acuity were evaluated. Results: During this time period 11 cases (1 female, 10 males) were included in the study. The mean age at the time of the implantation was 57.7 years (between 25–74 years). In 4 cases the iris clip lens was implanted during the first intervention, in 7 cases during the secondary procedure. In all cases the lens was fixated onto the iris posteriorly. The best corrected visual acuity before the iris clip implantation was 0.43 (0.1–1.0) and postoperatively at the time of the follow up 0.49 (0.04–1.0). Conclusions: With the use of the retropupillary implanted iris clip intraocular lens all of the patients could have been rehabilitated without major complications. Orv. Hetil., 2017, 158(1), 20–24.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2017.30607
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2017
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  • 8
    Online Resource
    Online Resource
    Malignus kevert Müller-cső-eredetű tumor komplex kezelése
    Akademiai Kiado Zrt. ; 2018
    In:  Orvosi Hetilap Vol. 159, No. 19 ( 2018-05), p. 741-747
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 159, No. 19 ( 2018-05), p. 741-747
    Abstract: Abstract: Introduction and aim: The aim of our study was to evaluate the prognostic factors and treatment options of a very rare and highly aggressive type of uterine neoplasms, the malignant mixed Müllerian tumor, known as carcinosarcoma. Method: Between 2009 and 2017, 29 patients were treated with malignant mixed Müllerian tumor. At stage I, surgery and postoperative radiotherapy were performed. At stages II−IV, trimodal treatment (surgery, chemotherapy and radiotherapy) was administered. Results: The average age of patients was 68.51 (49–90) years, mean body mass index was 30.22 (20.90–37.22). We have experienced recurrence of disease after complete resection in 6 cases (4 of 6 patients did not accept radiation therapy). Local recurrence has occurred after an average 15.52 (6−36) months, distant metastasis with an average 19.2 (8–32) months. Overall survival was 11.92 (1–75) months. Six patients are free of tumours at the moment. Conclusions: As overall survival has not increased in recent decades by using combined chemotherapy, there is no congruent consensus associated with the optimal treatment. The standard surgical treatment is total abdominal hysterectomy with bilateral oophorectomy, although due to high rates of recurrence and metastases, the necessity of lymphadenectomy and postoperative treatment is in the focus of recent studies. Though postoperative irradiation improves local control, the beneficial effect on overall survival is still not proven. Adjuvant chemotherapy decreases the rate of both pelvic and extrapelvic recurrence at the same time, although there is no recommendation for the optimal chemoterapeutic agent. Multimodal therapy should lead to better outcomes. Recently there are many ongoing studies with biologic and target therapies to improve efficiency, however, the relevant results will be disclosed in many years only, due to the small number of patients. Orv Hetil. 2018; 159(19): 741–7747.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2018.31039
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2018
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  • 9
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    Online Resource
    Colorectalis májmetastasisok komplex kezelése. Konszenzuskonferencia, Budapest, 2019. április 5.
    Akademiai Kiado Zrt. ; 2019
    In:  Orvosi Hetilap Vol. 160, No. Supplement 2 ( 2019-09), p. 2-20
    Details
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 160, No. Supplement 2 ( 2019-09), p. 2-20
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    URL: Article
    DOI: 10.1556/650.2019.31580
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2019
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  • 10
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    Online Resource
    Az együttműködő személy figyelmessége és eredményessége által keltett benyomások a megfigyelőben: tesz-e különbséget a társas értékorientáció kétféle szemüvege?
    Akademiai Kiado Zrt. ; 2011
    In:  Pszichológia Vol. 31, No. 2 ( 2011-06), p. 107-123
    Details
    In: Pszichológia, Akademiai Kiado Zrt., Vol. 31, No. 2 ( 2011-06), p. 107-123
    Type of Medium: Online Resource
    ISSN: 0230-0508 , 2060-2782
    URL: Article
    DOI: 10.1556/Pszicho.31.2011.2.2
    Language: Hungarian
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2011
    SSG: 5,2
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