In:
médecine/sciences, EDP Sciences, Vol. 35, No. 11 ( 2019-11), p. 859-865
Abstract:
Alcohol consumption during pregnancy constitutes a major cause of neurodevelopmental and behavioral disabilities. Whereas it is possible for clinicians to establish a perinatal diagnosis of fetal alcohol syndrome, the more severe expression of fetal alcohol spectrum disorder (FASD), most FASD children are late or mis-diagnosed due to a lack of clear morphological and neurodevelopmental abnormalities. Several precious years of care are consequently lost. Recent data revealed a functional placenta-brain axis involved in the control of the fetal brain angiogenesis which is impaired by in utero alcohol exposure. Because in the developing fetal brain a correct angiogenesis is required for a correct neurodevelopment, these preclinical and clinical advances pave the way for a new generation of placental biomarkers for early diagnosis of FASD.
Type of Medium:
Online Resource
ISSN:
0767-0974
,
1958-5381
DOI:
10.1051/medsci/2019167
Language:
French
Publisher:
EDP Sciences
Publication Date:
2019
detail.hit.zdb_id:
2049442-7
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