In:
Alcoholism: Clinical and Experimental Research, Wiley, Vol. 43, No. 7 ( 2019-07), p. 1403-1413
Abstract:
Liver injury and inflammation in alcoholic liver disease are associated with overactivation of the innate immune system. Among the cellular mechanisms that control inflammation, autophagy regulates the hepatic immune response in a number of liver diseases. In this study the protective role of macrophage autophagy was examined in a mouse model of alcoholic liver disease. Macrophage autophagy downregulates hepatic inflammation and liver injury, suggesting that therapies directed to increase macrophage autophagy might be beneficial in the treatment of alcoholic liver disease.
Type of Medium:
Online Resource
ISSN:
0145-6008
,
1530-0277
DOI:
10.1111/acer.2019.43.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2046886-6
detail.hit.zdb_id:
3167872-5
SSG:
15,3
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