In:
Cancer Science, Wiley, Vol. 105, No. 6 ( 2014-06), p. 660-666
Abstract:
Ajuba family proteins were reported to be transcription repressors regulating kinds of physiological process. However, roles of Ajuba family proteins in colorectal cancer ( CRC ) remain poorly studied. We found that JUB was highly upregulated in clinical specimens and CRC cell lines. JUB induced EMT and enhanced motility and invasiveness in CRC . Mechanistic studies revealed that JUB induces EMT via Snail and JUB is also required for Snail‐induced EMT . These findings uncovered that the LIM protein JUB serves as an oncogene in CRC by promoting EMT . Thus this may provide a novel target for therapy of metastatic CRC .
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2014.105.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
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