In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 20, No. 1 ( 2024-1-25), p. e1011982-
Abstract:
Influenza A virus (IAV) can cause severe respiratory infection leading to significant global morbidity and mortality through seasonal epidemics. Likewise, the constantly increasing number of cancer diseases is a growing problem. Nevertheless, the understanding of the mutual interactions of the immune responses between cancer and infection is still very vague. Therefore, it is important to understand the immunological cross talk between cancer and IAV infection. In several preclinical mouse models of cancer, including melanoma and colorectal cancer, we observed that IAV infection in the lung significantly decreased the tumour burden. Concomitantly, tumour-specific CD8 + T-cells are strongly activated upon infection, both in the tumour tissue and in the lung. CD8 + T-cell depletion during infection reverses the reduced tumour growth. Interestingly, IAV infection orchestrated the migration of tumour-specific CD8 + T-cells from the tumour into the infected lung. Blocking the migration of CD8 + T-cells prevented the anti-tumoural effect. Thus, our findings show that viral respiratory infection has significant impact on the anti-tumour CD8 + T-cell response, which will significantly improve our understanding of the immunological cross talk between cancer and infection.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1011982
DOI:
10.1371/journal.ppat.1011982.g001
DOI:
10.1371/journal.ppat.1011982.g002
DOI:
10.1371/journal.ppat.1011982.g003
DOI:
10.1371/journal.ppat.1011982.g004
DOI:
10.1371/journal.ppat.1011982.g005
DOI:
10.1371/journal.ppat.1011982.g006
DOI:
10.1371/journal.ppat.1011982.g007
DOI:
10.1371/journal.ppat.1011982.g008
DOI:
10.1371/journal.ppat.1011982.s001
DOI:
10.1371/journal.ppat.1011982.s002
DOI:
10.1371/journal.ppat.1011982.s003
DOI:
10.1371/journal.ppat.1011982.s004
DOI:
10.1371/journal.ppat.1011982.s005
DOI:
10.1371/journal.ppat.1011982.s006
DOI:
10.1371/journal.ppat.1011982.s007
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2024
detail.hit.zdb_id:
2205412-1
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