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  • 1
    Online Resource
    Online Resource
    Machine learning prediction of pathologic myopia using tomographic elevation of the posterior sclera
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-03-26)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-03-26)
    Abstract: Qualitative analysis of fundus photographs enables straightforward pattern recognition of advanced pathologic myopia. However, it has limitations in defining the classification of the degree or extent of early disease, such that it may be biased by subjective interpretation. In this study, we used the fovea, optic disc, and deepest point of the eye (DPE) as the three major markers (i.e., key indicators) of the posterior globe to quantify the relative tomographic elevation of the posterior sclera (TEPS). Using this quantitative index from eyes of 860 myopic patients, support vector machine based machine learning classifier predicted pathologic myopia an AUROC of 0.828, with 77.5% sensitivity and 88.07% specificity. Axial length and choroidal thickness, the existing quantitative indicator of pathologic myopia only reached an AUROC of 0.758, with 75.0% sensitivity and 76.61% specificity. When all six indices were applied (four TEPS, AxL, and SCT), the discriminative ability of the SVM model was excellent, demonstrating an AUROC of 0.868, with 80.0% sensitivity and 93.58% specificity. Our model provides an accurate modality for identification of patients with pathologic myopia and may help prioritize these patients for further treatment.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-85699-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 2
    Online Resource
    Online Resource
    Deviated Saccadic Trajectory as a Biometric Signature of Glaucoma
    Association for Research in Vision and Ophthalmology (ARVO) ; 2023
    In:  Translational Vision Science & Technology Vol. 12, No. 7 ( 2023-07-13), p. 15-
    Details
    In: Translational Vision Science & Technology, Association for Research in Vision and Ophthalmology (ARVO), Vol. 12, No. 7 ( 2023-07-13), p. 15-
    Type of Medium: Online Resource
    ISSN: 2164-2591
    URL: Article
    DOI: 10.1167/tvst.12.7.15
    Language: English
    Publisher: Association for Research in Vision and Ophthalmology (ARVO)
    Publication Date: 2023
    detail.hit.zdb_id: 2674602-5
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  • 3
    Online Resource
    Online Resource
    Microvasculature Dropout and Development of Normal Tension Glaucoma in Glaucoma Suspects: The Normal Tension Glaucoma Suspect Cohort Study
    Elsevier BV ; 2022
    In:  American Journal of Ophthalmology Vol. 243 ( 2022-11), p. 135-148
    Details
    In: American Journal of Ophthalmology, Elsevier BV, Vol. 243 ( 2022-11), p. 135-148
    Type of Medium: Online Resource
    ISSN: 0002-9394
    URL: Article
    DOI: 10.1016/j.ajo.2022.07.020
    RVK:
    XA 19500
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2019600-3
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  • 4
    Online Resource
    Online Resource
    Vision-related Quality of Life in Korean Glaucoma Patients
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Journal of Glaucoma Vol. 26, No. 2 ( 2017-02), p. 159-165
    Details
    In: Journal of Glaucoma, Ovid Technologies (Wolters Kluwer Health), Vol. 26, No. 2 ( 2017-02), p. 159-165
    Abstract: The purpose of the study was to evaluate vision-related quality of life in Korean glaucoma patients and to explore the associated factors. Methods: A total of 907 glaucoma patients were recruited from the prospectively designed LIGHT ( Li fe quality of the g laucoma patient w h o underwent t reatment) study organized by the Korean Glaucoma Society. Basic questionnaire that included items related to socioeconomic status, comorbidity, and lifestyle, and the validated Korean version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) were collected. The Rasch score, a logit-based interval scale estimate to summarizing the NEI VFQ-25 responses, was calculated. The univariate and multivariable regression models were used to evaluate associations between the Rasch score and variables. Results: The mean patient age was 58.1±14.1 years, visual field mean deviation (VF MD) of the better and worse eyes was −4.92±6.14 and −9.77±8.31 dB, binocular-integrated VF (IVF) MD was −3.55±5.31 dB, respectively. The lower NEI VFQ-25 Rasch score showed a significant association with the presence of other ocular diseases ( P =0.020), a high school level of education or less [vs. university ( P =0.006), vs. graduate school or higher ( P =0.019)], an anxious personality [vs. a moderate personality ( P 〈 0.001), vs. a relaxed personality ( P 〈 0.001)], the number of glaucoma medications in use ( P =0.049), worse eye visual acuity ( P 〈 0.001), and IVF MD ( P 〈 0.001). Conclusions: Visual function parameters are important for the vision-related quality of life of Korean glaucoma patients, notably for worse eye visual acuity and IVF MD. However, social factors, self-assessed personality, and treatment-related issues are also substantial predictors of overall life quality.
    Type of Medium: Online Resource
    ISSN: 1057-0829
    URL: Article
    DOI: 10.1097/IJG.0000000000000575
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2060541-9
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  • 5
    Online Resource
    Online Resource
    Comparison of Vision-related Quality of Life Between Normal Tension Glaucoma and Primary Open-angle Glaucoma
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Journal of Glaucoma Vol. 31, No. 5 ( 2022-05), p. 322-328
    Details
    In: Journal of Glaucoma, Ovid Technologies (Wolters Kluwer Health), Vol. 31, No. 5 ( 2022-05), p. 322-328
    Abstract: Although there was little difference in overall vision-related quality of life (VRQOL) between patients with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) after controlling for confounding factors, POAG tended to have poorer VRQOL, especially in social functioning and dependency, than NTG. Purpose: The fundamental goal of treatment of patients with glaucoma is to preserve their VRQOL. The aim of this study was to compare VRQOL between patients with NTG and those with POAG. Materials and Methods: The self-reported National Eye Institute Visual Function Questionnaire (NEI VFQ-25) survey was performed, including clinical, demographic, and socioeconomic data from 506 Korean patients with NTG and 287 with POAG. The mean deviation of the integrated binocular visual field was calculated using the best location method. The NEI VFQ-25 results were evaluated by Rasch analysis to control item difficulty and variation in individual response ability. Propensity score matching was used to control for various confounding factors affecting VRQOL. Results: Although patients with POAG tended to have worse VRQOL than those with NTG, there was no statistically significant between-group difference in ocular pain, near and distance activities, mental health, role difficulties, ability to drive, and the overall composite score. However, the social functioning ( P =0.016) and dependency ( P =0.026) were significantly poorer in POAG patients. Conclusions: Overall VRQOL in patients with NTG and POAG was found to be similar. However, social functioning and dependency were significantly worse in those with POAG. These findings are relevant to supporting glaucoma patients.
    Type of Medium: Online Resource
    ISSN: 1057-0829
    URL: Article
    DOI: 10.1097/IJG.0000000000002007
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2060541-9
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  • 6
    Online Resource
    Online Resource
    Factors influencing vision‐related quality of life according to glaucoma severity
    Wiley ; 2019
    In:  Acta Ophthalmologica Vol. 97, No. 2 ( 2019-03)
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 97, No. 2 ( 2019-03)
    Abstract: To identify factors influencing vision‐related quality of life ( VRQOL ) according to glaucoma severity. Methods A total of 901 patients with varying stages of glaucoma were recruited from the prospectively designed LIGHT (Life Quality of Glaucoma Patients Who Underwent Treatment) study organized by the Korean Glaucoma Society. Participants completed a basic questionnaire collecting socioeconomic status and clinical information, in addition to the 25‐item National Eye Institute Visual Function Questionnaire ( NEI VFQ ‐25). Subjects were classified by mean deviation ( MD ) of integrated binocular visual field ( IVF ) into mild, moderate and severe damage groups. Factors were evaluated for their influence on VRQOL according to glaucoma severity using univariate and multivariable regression models between Rasch‐analysed NEI VFQ ‐25 subscale scores and different variables. Results The mild, moderate and severe groups contained 720, 111 and 70 patients, respectively; the mean IVF MD in each group was −1.4, −8.5 and −17.9 dB . Significant differences were observed among the three groups with respect to age, IVF MD , visual acuity ( VA ), education level, income level, number of glaucoma medications prescribed and follow‐up period. The most influential factor associated with VRQOL according to glaucoma severity was VA . The VA of the better eye was much more influential on VRQOL than the VA of the worse eye in the moderate and severe defect groups, and the impact of VA on VRQOL was more prominent in advanced glaucoma. Conclusions Visual acuity is the most influential factor on VRQOL in patients with glaucoma. Preservation of VA should be strongly prioritized to maintain good VRQOL .
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.2019.97.issue-2
    DOI: 10.1111/aos.13918
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2466981-7
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  • 7
    Online Resource
    Online Resource
    Vertical disc tilt and features of the optic nerve head anatomy are related to visual field defect in myopic eyes
    Springer Science and Business Media LLC ; 2019
    In:  Scientific Reports Vol. 9, No. 1 ( 2019-03-05)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2019-03-05)
    Abstract: Myopia is significantly growing eye disease which accompanies various ocular pathologies including glaucoma. Understanding visual field (VF) and retinal nerve fiber layer (RNFL) damage observed in myopic eyes is important. Therefore, we evaluated optic disc margin anatomy using spectral-domain (SD) optical coherence tomography (OCT). We enrolled 40 healthy myopic patients and 64 myopic patients with RNFL defects in the superonasal region of the optic disc on red-free photographs and OCT. Optic disc stereophotographs were co-localized to SD-OCT images, and we analyzed the frequency with which the disc margin identified in photographs coincided with Bruch’s membrane (BM) opening, BM/border tissue, or border tissue. For each scan, the presence of border tissue overhang beyond the clinical disc margin and the end of Bruch’s membrane was identified. Among 64 myopic eyes with RNFL defects, 42 had corresponding inferotemporal VF defects. Border tissue overhang was found from 25 to 60% of myopic eyes with RNFL defect at all clock positions. However, border tissue overhang was found from 86 to 97% at 1, 2, 11 and 12 o’clock position in myopic eyes with VF defects. This was significantly different from myopic healthy eyes. We suggest that the OCT structure at the disc margin might contribute to VF damage in myopic patients.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-019-38960-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2615211-3
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  • 8
    Online Resource
    Online Resource
    Association of Scleral Deformation Around the Optic Nerve Head With Central Visual Function in Normal-Tension Glaucoma and Myopia
    Elsevier BV ; 2020
    In:  American Journal of Ophthalmology Vol. 217 ( 2020-09), p. 287-296
    Details
    In: American Journal of Ophthalmology, Elsevier BV, Vol. 217 ( 2020-09), p. 287-296
    Type of Medium: Online Resource
    ISSN: 0002-9394
    URL: Article
    DOI: 10.1016/j.ajo.2020.04.041
    RVK:
    XA 19500
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2019600-3
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  • 9
    Online Resource
    Online Resource
    Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-08-17)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-08-17)
    Abstract: This study investigated the predicted risk factors for the development of normal-tension glaucoma (NTG) in NTG suspects. A total of 684 eyes of 379 NTG suspects who were followed-up for at least 5 years were included in the study. NTG suspects were those having (1) intraocular pressure within normal range, (2) suspicious optic disc (neuroretinal rim thinning) or enlarged cup-to-disc ratio (≥ 0.6), but without definite localized retinal nerve fiber layer (RNFL) defects on red-free disc/fundus photographs, and (3) normal visual field (VF). Demographic, systemic, and ocular characteristics were determined at the time of the first visit via detailed history-taking and examination of past medical records. Various ocular parameters were assess using spectral-domain optical coherence tomography and Heidelberg retinal tomography. Conversion to NTG was defined either by the presence of a new localized RNFL defect at the superotemporal or inferotemporal region on disc/fundus red-free photographs, or presence of a glaucomatous VF defect on pattern standard deviation plots on two consecutive tests. Hazard ratios were calculated with the Cox proportional hazard model. In total, 86 (12.6%) of the 684 NTG suspects converted to NTG during the follow-up period of 69.39 ± 7.77 months. Significant ( P   〈  0.05, Cox regression) risk factors included medication for systemic hypertension, longer axial length, worse baseline VF parameters, thinner baseline peripapillary RNFL, greater disc torsion, and lamina cribrosa (LC) thickness  〈  180.5 μm (using a cut-off value obtained by regression analysis). Significant ( P   〈  0.05, Cox regression) risk factors in the non-myopic NTG suspects included medication for systemic hypertension and a LC thinner than the cut-off value. Significant ( P   〈  0.05, Cox regression) risk factors in the myopic NTG suspects included greater disc torsion. The results indicated that 12.6% of NTG suspects converted to NTG during the 5–6-year follow-up period. NTG suspects taking medication for systemic hypertension, disc torsion of the optic disc in the inferotemporal direction, and thinner LC of the optic nerve head at baseline were at greater risk of NTG conversion. Related baseline risk factors were different between myopic and non-myopic NTG suspects.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-95984-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 10
    Online Resource
    Online Resource
    Three-Dimensional Evaluation of Posterior Pole and Optic Nerve Head in Myopes with Glaucoma
    Springer Science and Business Media LLC ; 2017
    In:  Scientific Reports Vol. 7, No. 1 ( 2017-12-21)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-12-21)
    Abstract: The degree of myopia is represented by a global index, such as refractive error or axial length. However, the progression of myopia mainly develops in the posterior eyeball. Therefore, it is reasonable to assume that the evaluation of myopia should be confined to the posterior segment, where most of the growth and lengthening occurs. Swept source optical coherence tomography software can reconstruct the scans to the coronal view of the posterior pole, which provides additional anterior-posterior depth (z axis in the Cartesian coordinates) that is not provided with the common fundus photograph. We deduced that the parameter of deepest point of the eyeball (DPE) as a surrogate for posterior pole configuration. Between myopes with and without normal tension glaucoma (NTG) with similar axial length, myopes with NTG had deeper and more distant location of the DPE from the optic disc. The difference of the DPE position between the myopes with and without NTG may have implications for the larger optic disc tilt and torsion characteristic of myopes with NTG. Furthermore, these data suggest that myopes with NTG go through excessive posterior scleral remodeling, which may result in vulnerable optic nerve head.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-017-18297-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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