In:
Clinical Cardiology, Wiley, Vol. 40, No. 8 ( 2017-08), p. 549-553
Abstract:
The cardio‐ankle vascular index ( CAVI ) is a new noninvasive index to evaluate arterial stiffness. We investigated whether CAVI can predict severity, extent, and burden of coronary artery disease by comparing results with cardiac computed tomographic angiography ( CCTA ). Hypothesis CAVI may predict the presence of subclinical atherosclerosis. Methods We prospectively enrolled 95 patients (66% male; mean age, 50 ± 16 years) who underwent both CCTA and CAVI consecutively. We evaluated if CAVI correlated with (1) severe stenosis (≥50%); (2) plaque extent, determined by a segment‐involvement score ( SIS ), defined by the total number of coronary artery segments containing any plaque; and (3) plaque burden, determined by a segment‐stenosis score ( SSS ), defined by the extent of obstruction of coronary luminal diameter in individual coronary artery segments. Results Bivariate analysis showed a statistically significant relationship not only between CAVI and SIS , but also between CAVI and SSS ( r 2 = 0.4, P 〈 0.0001 for SIS ; r 2 = 0.36, P 〈 0.0001 for SSS ). Multivariable logistic analysis demonstrated that CAVI is significantly associated with SSS 〉 5 (odds ratio [ OR ]: 2.3, 95% confidence interval [ CI ]: 1.1‐7.8, P = 0.03) and SIS 〉 5 ( OR : 2.3, 95% CI : 1.1‐5.8, P = 0.02), but not severe stenosis ( OR : 1.7, 95% CI : 0.9‐4.3, P = 0.13), after adjusting for age, sex, chest pain, hypertension, dyslipidemia, family history, diabetes, and current smoking. Conclusions We demonstrated that CAVI had a significant relationship with subclinical coronary atherosclerosis evaluated by CCTA , especially in relation to plaque burden and plaque extent, but not severe stenosis. Thus, CAVI may reflect coronary atherosclerosis burden more than severity.
Type of Medium:
Online Resource
ISSN:
0160-9289
,
1932-8737
DOI:
10.1002/clc.2017.40.issue-8
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2048223-1
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