In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 31, No. 9 ( 2016-09), p. 1604-1610
Abstract:
To assess liver fibrosis stages in a liver fibrosis–early cirrhosis model in dogs, the clinical efficiency of contrast‐enhanced ultrasound (CEUS) and computed tomography (CT) perfusion imaging were compared. Methods Hepatic vein arriving time (HVAT), hepatic artery arriving time, and hepatic artery to vein transit time (HA‐VTT) were measured on CEUS. Total liver perfusion (TLP), portal vein perfusion (PVP), hepatic artery perfusion, and hepatic perfusion index (HPI) were measured on CT perfusion imaging. Histologic examination of liver specimens of the animals was performed to assess the fibrosis stage. Results For assessment of liver fibrosis, the area under the receiver operating characteristic curve of CEUS indexes HVAT and HA‐VTT were 0.865 and 0.930, respectively; the perfusion CT indexes TLP, PVP, and HPI were 0.797, 0.800, and 0.220, respectively; the serological index hyaluronic acid was 0.793. While for assessment of early cirrhosis, the area under the receiver operating characteristic curve of CEUS indexes HVAT and HA‐VTT were 0.915 and 0.948, respectively; the perfusion CT indexes TLP, PVP, and HPI were 0.737, 0.765, and 0.218, respectively; the serological index hyaluronic acid was 0.627. Conclusions This study showed that both CEUS and CT perfusion imaging have the potential to be complementary imaging tools in the evaluation of liver fibrosis. While CEUS is the better choice and the index HA‐VTT can be considered as non‐invasive semi‐quantitative indexes for diagnosing liver fibrosis and early cirrhosis.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2016.31.issue-9
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2006782-3
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