GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Development and validation of a model to predict acute kidney injury following wasp stings: A multicentre study
    Elsevier BV ; 2022
    In:  Toxicon Vol. 209 ( 2022-04), p. 43-49
    Details
    In: Toxicon, Elsevier BV, Vol. 209 ( 2022-04), p. 43-49
    Type of Medium: Online Resource
    ISSN: 0041-0101
    URL: Article
    DOI: 10.1016/j.toxicon.2022.02.003
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1498784-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Schizophrenia Genetics and Neuropsychiatric Features in Childhood-onset Systemic Lupus Erythematosus
    The Journal of Rheumatology ; 2022
    In:  The Journal of Rheumatology Vol. 49, No. 2 ( 2022-02), p. 192-196
    Details
    In: The Journal of Rheumatology, The Journal of Rheumatology, Vol. 49, No. 2 ( 2022-02), p. 192-196
    Abstract: We examined the association between schizophrenia genetic susceptibility loci and neuropsychiatric systemic lupus erythematosus (NPSLE) features in childhood-onset SLE (cSLE) participants. Methods Study participants from the Lupus Clinic at the Hospital for Sick Children, Toronto, met ≥ 4 of the American College of Rheumatology and/or SLE International Collaborating Clinics SLE classification criteria and were genotyped using the Illumina Multi-Ethnic Global Array or the Global Screening Array. Ungenotyped single-nucleotide polymorphisms (SNPs) were imputed, and ancestry was genetically inferred. We calculated 2 additive schizophrenia-weighted polygenic risk scores (PRS) using (1) genome-wide significant SNPs ( P 〈 5 × 10 –8 ), and (2) an expanded list of SNPs with significance at P 〈 0.05. We defined 2 outcomes compared to absence of NPSLE features: (1) any NPSLE feature, and (2) subtypes of NPSLE features (psychosis and nonpsychosis NPSLE). We completed logistic and multinomial regressions, first adjusted for inferred ancestry only and then added for variables significantly associated with NPSLE in our cohort ( P 〈 0.05). Results We included 513 participants with cSLE. Median age at diagnosis was 13.8 years (IQR 11.2–15.6), 83% were female, and 31% were of European ancestry. An increasing schizophrenia genome-wide association PRS was not associated with NPSLE (OR 1.04, 95% CI 0.87–1.26, P = 0.62), nor with the NPSLE subtypes, psychosis (OR 0.97, 95% CI 0.73–1.29, P = 0.84) and other nonpsychosis NPSLE (OR 1.08, 95% CI 0.88–1.34, P = 0.45), in ancestry-adjusted models. Results were similar for the model including covariates (ancestry, malar rash, oral/nasal ulcers, arthritis, lymphopenia, Coombs-positive hemolytic anemia, lupus anticoagulant, and anticardiolipin antibodies) and for the expanded PRS estimates. Conclusion We did not observe an association between known risk loci for schizophrenia and NPSLE in a multiethnic cSLE cohort. This work warrants further validation.
    Type of Medium: Online Resource
    ISSN: 0315-162X , 1499-2752
    URL: Article
    DOI: 10.3899/jrheum.210363
    RVK:
    XA 10000
    Language: English
    Publisher: The Journal of Rheumatology
    Publication Date: 2022
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Androgen and Its Receptor Promote Bax-Mediated Apoptosis
    Informa UK Limited ; 2006
    In:  Molecular and Cellular Biology Vol. 26, No. 5 ( 2006-03-01), p. 1908-1916
    Details
    In: Molecular and Cellular Biology, Informa UK Limited, Vol. 26, No. 5 ( 2006-03-01), p. 1908-1916
    Type of Medium: Online Resource
    ISSN: 1098-5549
    URL: Article
    DOI: 10.1128/MCB.26.5.1908-1916.2006
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2006
    detail.hit.zdb_id: 1474919-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Effects of a Nurse-Led Phone Follow-up Education Program Based on the Self-efficacy Among Patients With Cardiovascular Disease
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Journal of Cardiovascular Nursing Vol. 33, No. 1 ( 2018-1), p. E15-E23
    Details
    In: Journal of Cardiovascular Nursing, Ovid Technologies (Wolters Kluwer Health), Vol. 33, No. 1 ( 2018-1), p. E15-E23
    Abstract: The integration of self-efficacy (SE) theory within a nurse-led telephone follow-up education program (NP-FEP) has not been extensively evaluated for patients with cardiovascular disease. Objectives: The aim of this study is to determine the effectiveness of an NP-FEP in improving SE (primary outcome) and achieving goals related to cardiovascular risk (secondary outcome) for patients with cardiovascular disease. Methods: In June and July 2013, a total of 403 patients with cardiovascular disease in Shanghai were randomized into the intervention and control groups. Personalized end goals were established for improving cardiovascular risk for each patient. The control group received conventional follow-up education, whereas the intervention group was contacted by telephone 11 times over a 6-month period with staged goals developed based on SE theory. Self-efficacy scores and goals for reducing cardiovascular risk were assessed at baseline, at the end of the 6-month intervention, and 12 months after enrollment. Results: The SE scores in both groups increased at 6 months and decreased slightly at 12 months. The baseline SE scores were similar between the groups ( P 〉 .05), but the average SE scores were increased more for the intervention group than for the control group at 6 ( P 〈 .05) and 12 ( P 〈 .05) months. In addition, the final goal achievement rates for the intervention group were significantly higher than for the control group ( P 〈 .05). The difference between the 2 groups was reflected by differences in cardiac disease risk factors defined by the World Health Organization. Conclusion: The NP-FEP improved SE and facilitated achievement of goals related to risk factors in patients with cardiovascular disease for at least 1 year.
    Type of Medium: Online Resource
    ISSN: 1550-5049 , 0889-4655
    URL: Article
    DOI: 10.1097/JCN.0000000000000414
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2053461-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    UPLC/Q-TOF-MS-based Metabolomics Study of the Antiosteoporosis Effects of Vaccarin in Ovariectomized Mice
    Georg Thieme Verlag KG ; 2023
    In:  Planta Medica Vol. 89, No. 02 ( 2023-02), p. 218-230
    Details
    In: Planta Medica, Georg Thieme Verlag KG, Vol. 89, No. 02 ( 2023-02), p. 218-230
    Abstract: Osteoporosis is a systemic and metabolic bone disease that usually occurs in postmenopausal women, which mainly manifests as bone loss and increased bone fragility that both facilitate fracture. However, few drugs for osteoporosis have shown good efficacy and limited side effects. Vaccarin has demonstrated its antiosteoporosis effects by inhibiting the formation and osteolytic activities of osteoclasts in our previous investigation. In this study, multivariate statistical analysis and ultrahigh-performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry were used to analyze the serum metabolites of ovariectomized mice treated with or without vaccarin. As a result, 9 serum metabolites were identified as biomarkers. The metabolic levels of 3 crucial biomarkers, namely, lysophosphatidylcholine [22 : 6, (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)], 1-linoleoylglycerophosphocholine and 1-palmitoyl-Sn-glycero-3-phosphocholine, that were correlated with glycerophospholipid metabolism increased and then decreased significantly after vaccarin treatment. Molecular docking analysis and osteoclasts differentiation experiment further revealed that vaccarin may bind with phospholipase A2 and downregulated its activity to reduce the osteoclastogenesis. Therefore, the occurrence of osteoporosis is closely related with glycerophospholipid metabolism disorders, and vaccarin exerts antiosteoporosis effects by reducing the levels of glycerophospholipid metabolites.
    Type of Medium: Online Resource
    ISSN: 0032-0943 , 1439-0221
    URL: Article
    DOI: 10.1055/a-1942-5428
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2023
    detail.hit.zdb_id: 2037089-1
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Genetics of longitudinal kidney function in children and adults with systemic lupus erythematosus
    Oxford University Press (OUP) ; 2023
    In:  Rheumatology ( 2023-03-14)
    Details
    In: Rheumatology, Oxford University Press (OUP), ( 2023-03-14)
    Abstract: Genome-wide association studies (GWAS) have identified loci associated with estimated glomerular filtration rate (eGFR). Few LN risk loci have been identified to date. We tested the association of SLE and eGFR polygenic risk scores (PRS) with repeated eGFR measures from children and adults with SLE. Methods Patients from two tertiary care lupus clinics that met ≥4 ACR and/or SLICC criteria for SLE were genotyped on the Illumina MEGA or Omni1-Quad arrays. PRSs were calculated for SLE and eGFR, using published weighted GWA-significant alleles. eGFR was calculated using the CKD-EPI and Schwartz equations. We tested the effect of eGFR- and SLE-PRSs on eGFR mean and variance, adjusting for age at diagnosis, sex, ancestry, follow-up time, and clinical event flags. Results We included 1158 SLE patients (37% biopsy-confirmed LN) with 36 733 eGFR measures over a median of 7.6 years (IQR: 3.9–15.3). LN was associated with lower within-person mean eGFR [LN: 93.8 (s.d. 26.4) vs non-LN: 101.6 (s.d. 17.7) mL/min per 1.73 m2; P  & lt; 0.0001] and higher variance [LN median: 157.0 (IQR: 89.5, 268.9) vs non-LN median: 84.9 (IQR: 46.9, 138.2) (mL/min per 1.73 m2)2; P  & lt; 0.0001]. Increasing SLE-PRSs were associated with lower mean eGFR and greater variance, while increasing eGFR-PRS was associated with increased eGFR mean and variance. Conclusion We observed significant associations between SLE and eGFR PRSs and repeated eGFR measurements, in a large cohort of children and adults with SLE. Longitudinal eGFR may serve as a powerful alternative outcome to LN categories for discovery of LN risk loci.
    Type of Medium: Online Resource
    ISSN: 1462-0324 , 1462-0332
    URL: Article
    DOI: 10.1093/rheumatology/kead119
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1474143-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Non-contact detection of polyester filament yarn tension in the spinning process by the laser Doppler vibrometer method
    SAGE Publications ; 2022
    In:  Textile Research Journal Vol. 92, No. 5-6 ( 2022-03), p. 919-928
    Details
    In: Textile Research Journal, SAGE Publications, Vol. 92, No. 5-6 ( 2022-03), p. 919-928
    Abstract: The precise detection of polyester filament yarn (PFY) tension in the spinning process is critical to ensure product quality. The laser Doppler vibrometer (LDV) method is proposed to achieve non-contact detection of PFY tension in this paper. By employing the Hamilton principle, the transverse dynamics differential equations of PFY are derived, which are discretized and solved by the Galerkin method and Runge–Kutta method, respectively. In the equations, the PFY between two adjacent rollers is simplified as an axially moving string to verify the generality of calculating natural frequencies. The calculated natural frequencies from the axially moving string model are compared with solved results from the transverse dynamics differential equations. It is shown that the approximation of natural frequencies can be obtained from the axially moving string model. This study attempts to establish an approximate generic model among the PFY tension, the spinning speed and the first natural frequency based on axially moving string model, from which the PFY tension can be calculated efficiently by employing the measured natural frequencies. The LDV method is used to measure the natural frequencies. A major advantage of the proposed method is to realize non-contact detection of PFY tension. The method is more useful under high-speed spinning conditions where contact tension detectors are not available. An experimental analysis is carried out to verify the effectiveness and accuracy of the proposed method. Therefore, it is believed that the non-contact detection of PFY tension in the spinning process by the LDV method is feasible.
    Type of Medium: Online Resource
    ISSN: 0040-5175 , 1746-7748
    URL: Article
    DOI: 10.1177/00405175211034246
    RVK:
    ZS 0001
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2209596-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Numerical study of cold start performance of proton exchange membrane fuel cell with coolant circulation
    Elsevier BV ; 2019
    In:  International Journal of Hydrogen Energy Vol. 44, No. 39 ( 2019-08), p. 22160-22172
    Details
    In: International Journal of Hydrogen Energy, Elsevier BV, Vol. 44, No. 39 ( 2019-08), p. 22160-22172
    Type of Medium: Online Resource
    ISSN: 0360-3199
    URL: Article
    DOI: 10.1016/j.ijhydene.2019.06.147
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1484487-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Performance Investigation of Proton‐Exchange Membrane Fuel Cell with Dean Flow Channels
    Wiley ; 2022
    In:  Energy Technology Vol. 10, No. 3 ( 2022-03)
    Details
    In: Energy Technology, Wiley, Vol. 10, No. 3 ( 2022-03)
    Abstract: Herein, a novel fuel cell flow field with 3 π /2 radian Dean flow channels and its impact on the performance of proton exchange membrane fuel cells are presented. With a multidisciplinary numerical model, flow characteristics, concentration distribution, and current density contour in the fuel cell are compared between straight and Dean flow channel cases. The unstable vortices formed in the Dean flow channels are shown to enhance mass transfer of both reactants and water. As a result, although the voltage under low current density is slightly lower than that of fuel cells with straight channels, the output performance under high current density is observably improved. It is also found that the enhancement of oxygen transport with the Dean channel is more significant at relatively small cathode stoichiometry. In addition, by reducing the gas diffusion layer porosity, the membrane is kept at high humidity, yielding an improvement in power output and stability of the fuel cell at low cathode inlet pressure operation.
    Type of Medium: Online Resource
    ISSN: 2194-4288 , 2194-4296
    URL: Issue
    URL: Article
    DOI: 10.1002/ente.v10.3
    DOI: 10.1002/ente.202100851
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2700412-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Effects of Endplate Assembly on Cold Start Performance of Proton Exchange Membrane Fuel Cell Stacks
    Wiley ; 2021
    In:  Energy Technology Vol. 9, No. 7 ( 2021-07)
    Details
    In: Energy Technology, Wiley, Vol. 9, No. 7 ( 2021-07)
    Abstract: A proton exchange membrane fuel cell (PEMFC) stack has two endplate assemblies (EAs) to stabilize the multilayered structure and distribute the preload evenly on each cell. Thermal inertia of and heat loss through the EA are crucial factors for developing novel thermal and water management strategies for PEMFC stacks. Herein, a 3D multidisciplinary transient model is established to assess the effects of EAs on the cold start performance of PEMFC stacks. The underlying mechanism linked to the EA effects is revealed through the analysis of temperature distribution, current density distribution, ice formation, and water balance calculation. The predicted results show that the EA has a significant impact on temperature and ice distributions in the end cell, thus negatively affecting the end cell performance. It is found that the smaller water diffusivity caused by the lower temperature in end cells results in more ice accumulation in the middle of cathode catalyst layer (CCL). The temperature of the end cells is greatly influenced by the thermal mass of the bus plate. For a low start‐up temperature of −30 °C, the impact of EA becomes more significant and the end cell is completely filled up by ice and therefore shuts down.
    Type of Medium: Online Resource
    ISSN: 2194-4288 , 2194-4296
    URL: Issue
    URL: Article
    DOI: 10.1002/ente.v9.7
    DOI: 10.1002/ente.202100092
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2700412-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...