In:
The Journal of Clinical Hypertension, Wiley, Vol. 14, No. 2 ( 2012-02), p. 85-91
Abstract:
The authors hypothesized that carvedilol controlled‐release plus lisinopril combination therapy (C+L) would increase endothelial function and decrease oxidative stress to a greater extent than hydrochlorothiazide plus lisinopril combination therapy (H+L) in obese patients with hypertension. Twenty‐five abdominally obese patients (aged 54.4±7.3 years; 14 women) with hypertension/prehypertension were enrolled in a 7‐month (two 3‐month treatment periods separated by a 1‐month washout), randomized, double‐blind, controlled, crossover clinical trial comparing C+L vs H+L. Endothelial function, measured by digital reactive hyperemic index (RHI), circulating oxidized low‐density lipoprotein (oxLDL), 8‐isoprostane, and asymmetric dimethylarginine (ADMA) were obtained at baseline, post‐period 1, post‐washout, and post‐period 2. Analyses were adjusted for baseline measurements by analysis of covariance, with robust variance estimation for confidence intervals and P values. C+L treatment compared to H+L treatment significantly improved RHI (0.74, 95% confidence interval, 0.31–1.19, P =.001). This difference persisted after adjustment for the change in systolic blood pressure. No significant treatment differences were observed for oxLDL, 8‐isoprostane, or ADMA. These data provide evidence that independent of blood pressure–lowering, C+L therapy improves endothelial function to a greater extent than H+L therapy. Levels of oxidative stress were not significantly different between treatments, suggesting that other mechanisms may be responsible for the improvement in endothelial function.
Type of Medium:
Online Resource
ISSN:
1524-6175
,
1751-7176
DOI:
10.1111/jch.2012.14.issue-2
DOI:
10.1111/j.1751-7176.2011.00569.x
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2058690-5
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