In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2022-5-6), p. e0268033-
Abstract:
Pain management is currently important in neonatal intensive care unit (NICU). The superiority in pain relief of the combined oral sucrose (OS) and nonnutritive sucking (NNS) to other single intervention has not been well established. The administration of sucrose has been considered to potentially induce adverse events, which has been controversial. This study aims to investigate the combined effects and safety in comparison with other single intervention methods, including NNS, OS alone, breast milk and oral glucose. Methods We searched databases including Medline (via Pubmed), Embase (via Ovid), web of science, and Cochrane Library for randomized controlled trials from Jan 1, 2000 to Mar 31, 2021. The data were analyzed in the meta-analysis using Review manager Version 5.3. Pain score was the primary outcome in this meta-analysis. The adverse events were assessed qualitatively. Results A total of 16 studies were eligible in the meta-analysis. The results demonstrated a significant reduction in pain score in the NNS+OS group compared with NNS alone (SMD = -1.69, 95%CI, -1.69,-0.65) or sucrose alone (SMD = -1.39, 95% CI, -2.21,-0.57) during the painful procedures. When compared NNS+OS with breast milk, no significant difference was detected (SMD = -0.19, 95% CI: -0.5, 0.11). Conclusion The combined effects of NNS and OS might be superior to other single intervention method. However, the effects might be mild for moderate-to-severe pain.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0268033
DOI:
10.1371/journal.pone.0268033.g001
DOI:
10.1371/journal.pone.0268033.g002
DOI:
10.1371/journal.pone.0268033.g003
DOI:
10.1371/journal.pone.0268033.g004
DOI:
10.1371/journal.pone.0268033.g005
DOI:
10.1371/journal.pone.0268033.g006
DOI:
10.1371/journal.pone.0268033.g007
DOI:
10.1371/journal.pone.0268033.g008
DOI:
10.1371/journal.pone.0268033.g009
DOI:
10.1371/journal.pone.0268033.t001
DOI:
10.1371/journal.pone.0268033.t002
DOI:
10.1371/journal.pone.0268033.t003
DOI:
10.1371/journal.pone.0268033.s001
DOI:
10.1371/journal.pone.0268033.s002
DOI:
10.1371/journal.pone.0268033.s003
DOI:
10.1371/journal.pone.0268033.r001
DOI:
10.1371/journal.pone.0268033.r002
DOI:
10.1371/journal.pone.0268033.r003
DOI:
10.1371/journal.pone.0268033.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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