In:
Cardiology, S. Karger AG, Vol. 114, No. 3 ( 2009), p. 157-163
Abstract:
〈 i 〉 Objective: 〈 /i 〉 Several invasive studies have reported delayed reendothelialization and endothelial dysfunction following sirolimus-eluting stent (SES) implantation. We evaluated the changes in coronary endothelial function following SES implantation by using a noninvasive method that involved positron emission tomography and cold pressor testing (CPT). 〈 i 〉 Methods: 〈 /i 〉 The study was conducted on 14 lesions on which percutaneous coronary intervention (PCI) was successively performed. The lesions were classified into 2 groups depending on the PCI performed: the conventional PCI group, in which 7 conventional PCIs (plain old balloon angioplasty or bare-metal stents) were performed, and the SES group, in which 7 SESs were implanted. Coronary endothelial function was defined as the percent increase in the myocardial blood flow (MBF) during CPT. 〈 i 〉 Results: 〈 /i 〉 The resting MBF in the segments distal to the PCI sites did not differ between the conventional PCI and SES groups; however, the MBF significantly decreased in the SES group during CPT. 〈 i 〉 Conclusions: 〈 /i 〉 These data suggest that SES implantation induces coronary endothelial dysfunction in the segments distal to the PCI sites.
Type of Medium:
Online Resource
ISSN:
0008-6312
,
1421-9751
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
80092-2
detail.hit.zdb_id:
1482041-9
Permalink