In:
The Journal of Immunology, The American Association of Immunologists, Vol. 204, No. 1_Supplement ( 2020-05-01), p. 160.26-160.26
Abstract:
Neuroinflammation is considered a major factor in several neuropsychiatric disorders. Gypenosides (GPS) have pharmacological properties with multiple beneficial effects including anti-inflammatory and protective properties. In the present study, whether GPS could anxiolytic-like effects and chronic inflammation induced by injecting lipopolysaccharide (LPS) into rat hippocampus was investigated. Effects of GPS on inflammatory factors in the hippocampus and the mechanisms of these effects were also examined. Induction of LPS into the lateral ventricle caused inflammatory reactions, anxiety-like symptoms on the rats. Every day treatment of GPS for 21 consecutive days significantly increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. GPS administration significantly reduced the freezing response to contextual fear conditioning. GPS administration significantly decreased pro-inflammatory mediators such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and nuclear factor-kappaB (NF-κB) levels in the brain. Furthermore, GPS reduced LPS-induced elevated levels of toll-like receptor 4 (TLR4) mRNA, and inhibition of brain-derived neurotrophic factor (BDNF) mRNA level. Collectively, these results showed that GPS may anxiolytic-like effects and provide a potential therapy for anxiety-like behaviors caused by neuroinflammation.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.204.Supp.160.26
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2020
detail.hit.zdb_id:
1475085-5
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