In:
FEBS Letters, Wiley, Vol. 591, No. 18 ( 2017-09), p. 2879-2889
Abstract:
The expression of pluripotency genes fluctuates in a population of embryonic stem (ES) cells and the fluctuations in the expression of some pluripotency genes correlate. However, no correlation in the fluctuation of Pou5f1 , Zfp42 , and Nanog expression was observed in ES cells. Correlation between Pou5f1 and Zfp42 fluctuations was demonstrated in ES cells containing a knockout in the NuRD component Mbd3 . ES cells containing a triple knockout in the DNA methyltransferases Dnmt1 , Dnmt3a , and Dnmt3b showed correlation between the fluctuation of Pou5f1 , Zfp42 , and Nanog gene expression. We suggest that an epigenetic barrier is key to preventing the propagation of fluctuating pluripotency gene expression in ES cells.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.2017.591.issue-18
DOI:
10.1002/1873-3468.12791
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1460391-3
SSG:
12
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